Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention

Wu, Yanling; Ding, Yanping; Tanaka, Yoshimasa; Zhang, Wen

doi:10.7150/ijms.10001

Cited by 928 publications

(767 citation statements)

References 192 publications

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“…Type 2 diabetes is a complex disease caused by both genetic and environmental factors [1]. Currently, genome-wide Jing Yan, Danfeng Peng and Feng Jiang contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9 year prospective cohort study in the Chinese population

et al. 2016

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Aims/hypothesis We aimed to evaluate the combined effects of type 2 diabetes risk variants on predicting deterioration of blood glucose and progression of beta cell function and insulin sensitivity in a 9 year prospective cohort from the Chinese population. Methods We constructed a weighted genetic risk score (GRS) model based on 40 variants associated with type 2 diabetes validated in an established cross-sectional Chinese population (n = 6,822). The weighted scores were categorised into tertiles to assess the predictive capacity for incidence of type 2 diabetes and impaired glucose regulation (IGR), as well as for changes in Stumvoll first-and second-phase insulin secretion indices and Gutt's insulin sensitivity index (ISI) in a community-based 9 year prospective cohort (n = 2,495), including 2,192 individuals with normal glucose tolerance and 303 with IGR at baseline, through logistic, Cox and multiple linear regression tests. Results Weighted GRS predicted the incidence of type 2 diabetes and IGR in logistic regression (OR 1.236, 95% CI 1.100, 1.389, p = 0.0004) as well as in the Cox model (HR 1.129, 95% CI 1.026, 1.242, p = 0.0128) after adjusting for age, sex, BMI, smoking and alcohol status at baseline. Moreover, we observed that weighted GRS was able to predict deterioration in beta cell function (β = −0.0480, p = 9.66 × 10 −5 and β = −0.0303, p = 3.32 × 10 −5 for first-and second-phase insulin secretion, respectively), but not insulin sensitivity (p = 0.3815), during the 9 year follow-up period. Conclusions/interpretation The weighted GRS predicted blood glucose deterioration arising from change in beta cell function in the Chinese population. Individuals in the intermediate-or high-weighted GRS group exhibited progressive deterioration of beta cell function.

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“…Type 2 diabetes is a complex disease caused by both genetic and environmental factors [1]. Currently, genome-wide Jing Yan, Danfeng Peng and Feng Jiang contributed equally to this work.…”

Section: Introductionmentioning

confidence: 99%

Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9 year prospective cohort study in the Chinese population

et al. 2016

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“…Environmental factors (such as nutrition and physical activity) are also, effective in development of this phenotypic occurrence (47). Besides, other factors such as obesity, lack of physical activity and diet are involved in the development of such disease (48). In general, the result of TNF-α gene polymorphism and T2DM is inconsistent.…”

Section: Discussionmentioning

confidence: 98%

Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis

Dehkordi¹,

Dousti²,

Kiani³

et al. 2018

J Nephropathol

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Context: Type 2 diabetes mellitus (T2DM) is a multi-factorial disease with several genetic and environmental factors known to be associated with the disease. Tumor necrosis factoralpha (TNF-α) acts on fat cells associated with increased insulin resistance and obesity and its increase can be associated with the prevalence of T2DM. Previous studies on the relationship between 308 G/A polymorphism in TNF-α and T2DM were not conclusive. The aim of this study was to investigate the association between 308 G/A polymorphism in TNF-α gene and T2DM using a systematic review and meta-analysis. Evidence Acquisitions: In this systematic review we searched all published studies about the association between TNF 308 G/A polymorphism and T2DM through databases such as Scopus, Science direct, PubMed and Google scholar. A fixed or random effect model was used on the basis of heterogeneity. The heterogeneity was assessed using the I 2 index. We used STATA software (version 11.2) for data analysis. Results: In 22 selected papers, the total number of T2DM and control subject was 8485 and 8615, respectively. Odds ratios (ORs) with 95% confidence intervals(CI) for the GG genotype polymorphism 308 G/A in total, Asian populations and whites (Caucasian) were estimated as OR = 0.98 (95% CI: 0.96-1.00), OR = 0.96 (95% CI: 0.93 to 0.99) and OR =1.00 (95% CI: 0.97 to 1.40). The Publication Bias/or heterogeneity was observed in this study. Conclusions:The present investigation have shown that 308 G/A polymorphism GG and GA genotypes in TNF-α gene cannot be considered as predictors of T2DM (P < 0.05). ABSTRACT Implication for health policy/practice/research/medical education:In a systematic review on 22 selected papers, we found that 308 G/A polymorphism GG and GA genotypes in TNF-α gene cannot be considered as predictors of type 2 diabetes mellitus (P < 0.05). Please cite this paper as: Hasanpour Dehkordi A, Dousti M, Kiani F, Zamanian Azodi M, Rezaei-Tavirani M, Sayehmiri K. Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis. J Nephropathol. 2018;7(1):25-31.

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“…Diabetes incidence was inversely associated wealth status as lifecourse SES affected the long-term nutritional status of a person, by the habit of consuming excessive amounts of refined grains, sugar-sweetened beverages, red and processed meat and others with the opposite effects of healthy eating. 25,26 Having all of the risk factors, the public need to get information that the essential medicines and basic technologies for early detection, diagnosis and monitoring of diabetes at primary care level are now available. 27,28 Indonesia is already capable to procure the three essential medicines for diabetes management, namely insulin, metformin and sulphonylurea(s).…”

Section: Discussionmentioning

confidence: 99%

Risk Differences between Elderly Men and Women toward Doctor-Diagnosed Diabetes Mellitus in Urban Areas in Indonesia: 2013 National Basic Health Research Data

Budiharsana

2017

Kesmas: National Public Health Journal

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Diabetes mellitus (DM) is one of the most common non-communicable diseases (NCDs) in Indonesia. Reportedly that DM is associated with various risk factors. Notably, it seems that the rising prevalence rates reflect changes in urban lifestyle. This study aimed to examine risk differences in the prevalence of DM among men and women aged 15 years and older that lived in urban areas in Indonesia. Analysis used secondary data of 2013 National Basic Health Research, which applied a cross-sectional study design. The total of sample was 333,731 respondents. Data processing and analysis used multiple logistic regression method. In general, findings showed that doctor-diagnosed diabetes mellitus (DDDM) among urban men and women aged 15-39 years did not differ. However, the odds ratio of DDDM among older women aged 50-64 years was 30 times higher than women aged 15-39 years, while among the same age men was 21 times higher than younger men aged 15-39 years (p value < 0.001). In conclusion, entering the age of 50 years, women show a much higher risk of contracting DDDM than women with younger age, also much higher than older men towards younger men. Keywords: Age, diabetes mellitus, men, urban, women Abstrak Diabetes melitus (DM) adalah salah satu penyakit tidak menular yang paling umum di Indonesia. DM disebabkan berbagai faktor risiko. Peningkatan prevalensi DM salah satunya disebabkan oleh perubahan gaya hidup di perkotaan. Penelitian ini bertujuan untuk menguji perbedaan prevalensi DM yang didiagnosis dokter pada laki-laki dan perempuan usia 15 tahun keatas yang tinggal di daerah perkotaan di Indonesia. Analisis menggunakan data sekunder Riset Kesehatan Dasar (Riskesdas) 2013 dengan desain studi potong lintang. Total sampel sebanyak 333.731 responden. Metode analisis menggunakan regresi logistik ganda. Hasil menunjukkan bahwa DM yang didiagnosis dokter pada laki-laki dan perempuan usia 15-39 tahun di perkotaan tidak berbeda. Meski demikan, memasuki kurun usia 50-64 tahun, responden perempuan menunjukkan risiko terdiagnosis DM 30 kali lebih tinggi dibandingkan perempuan berusia 15-39 tahun, sementara laki-laki berusia 50-64 tahun berisiko 21 kali lebih tinggi dari laki-laki berusia 15-39 tahun (nilai p < 0,001). Penelitian ini menyimpulkan perempuan yang memasuki usia 50 tahun berisiko terkena DM jauh lebih besar dari pada perempuan yang berusia lebih muda dan risiko ini lebih besar daripada laki-laki berusia lanjut terhadap laki-laki berusia lebih muda.

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Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention

Cited by 928 publications

References 192 publications

Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9 year prospective cohort study in the Chinese population

Impaired pancreatic beta cell compensatory function is the main cause of type 2 diabetes in individuals with high genetic risk: a 9 year prospective cohort study in the Chinese population

Tumor necrosis factor-alpha 308 G/A polymorphism and type 2 diabetes mellitus; a systematic review and meta-analysis

Risk Differences between Elderly Men and Women toward Doctor-Diagnosed Diabetes Mellitus in Urban Areas in Indonesia: 2013 National Basic Health Research Data

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