Risk factors contributing to fracture non-unions

Calori, G.M.; Albisetti, W.; Agus, Anugrah; Iori, Stefano; Tagliabue, L.

doi:10.1016/s0020-1383(07)80004-0

Cited by 235 publications

(163 citation statements)

References 31 publications

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“…Reproduced and modified from (13). 5-10% of all fractures are prone to delayed bony union or will progress towards a non-union and the development of a pseudarthrosis (23)(24). Together with large traumatic bone defects and extensive loss of bone substance after tumour resection or revision surgery after failed arthroplasties, these pathological conditions still represent a major challenge in today's clinical practice.…”

Section: Bone Biologymentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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The role of Bone Tissue Engineering in the field of Regenerative Medicine has been the topic of substantial research over the past two decades. Technological advances have improved orthopaedic implants and surgical techniques for bone reconstruction. However, improvements in surgical techniques to reconstruct bone have been limited by the paucity of autologous materials available and donor site morbidity. Recent advances in the development of biomaterials have provided attractive alternatives to bone grafting expanding the surgical options for restoring the form and function of injured bone. Specifically, novel bioactive (second generation) biomaterials have been developed that are characterised by controlled action and reaction to the host tissue environment, whilst exhibiting controlled chemical breakdown and resorption with an ultimate replacement by regenerating tissue. Future generations of biomaterials (third generation) are designed to be not only osteoconductive but also osteoinductive, i.e. to stimulate regeneration of host tissues by combining tissue engineering and in situ tissue regeneration methods with a focus on novel applications. These techniques will lead to novel possibilities for tissue regeneration and repair. At present, tissue engineered constructs that may find future use as bone grafts for complex skeletal defects, whether from post-traumatic, degenerative, neoplastic or congenital/developmental "origin" require osseous reconstruction to ensure structural and functional integrity. Engineering functional bone using combinations of cells, scaffolds and bioactive factors is a promising strategy and a particular feature for future development in the area of hybrid materials which are able to exhibit suitable biomimetic and mechanical properties. This review will discuss the state of the art in this field and what we can expect from future generations of bone regeneration concepts.

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Section: Bone Biologymentioning

confidence: 99%

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

et al. 2013

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“…Der Frakturheilungsprozess wird von verschiedenen patientenabhängigen und patientenunabhängigen Faktoren beeinflusst, die maßgeblich für einen zeitgerechten Heilungsverlauf (mit) verantwortlich sind [5]. Von großer Bedeutung für die Dauer des Konsolidierungsprozesses ist darüber hinaus nicht zuletzt die Lokalisation der Fraktur.…”

Section: Definition Und Klassifikationunclassified

Pseudarthrosen

Raschke

Roßlenbroich

Everding

2017

Trauma Berufskrankh

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“…Kaynamama ya da yanlış kaynama için genel risk faktörlerinin; cinsiyet, yaş, diyabet, obezite, sigara ve alkol kullanımı, osteoporoz ve non-steroid antiinflamatuar ilaçlar olduğu bildirilmiştir. Vasküler hasarlar ise, lokal risk faktörleri arasında yer almaktadır (35,34). Ön kolun a. radialis ve a. ulnaris tarafından oluşturulan kollateraller ile dolaşımı sağlanmaktadır.…”

Section: Gereç Ve Yöntemunclassified

Humerus, Radius Ve Ulna’daki̇ Foramen Nutricium’larin Anatomi̇si̇ (Bi̇r Derleme)

Korkmaz¹,

Gürses²,

Gayretli³

et al. 2016

İst Tıp Fak D

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The nutrient foramina are reported as a cause for union defects in humerus, radius and ulna fractures. We aimed to review the relationship between the anatomy of the nutrient foramina and fractures of these bones. Materials and Methods:We performed an internet search via Pubmed and Google Scholar. We obtained full-text articles of 27 papers. We included 23 articles in our study. Eight studies investigated only humerus, 1 investigated radius, 1 investigated ulna, 1 investigated radius and ulna, and 12 investigated all three bones. We used additional 21 articles for a clinical viewpoint. Therefore 44 references were included in our study. Results: For humerus, foraminal index (the ratio of the distance between nutrient foramen and proximal end of the bone to total bone length) ranged between 32.7 and 59.1, and mostly the foramina located at the anteromedial surface. For radius, foraminal index ranged between 32.7 and 44.52, and mostly the foramina located at the anterior surface. For ulna, foraminal index ranged between 35.7 and 41.97, and mostly the foramina located at the anterior surface. Conclusion:The number and location of the foramina are concordant among different ethical groups. The most common site of union defects for humerus is the proximal 1/3. This complication is attributed to the attachments of strong skeletal muscles to this region. In forearm, non-unions tend to occur at the distal 1/3. At this region, blood supply is diminished due to the decrease of number of branches from the nutrient artery.

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Risk factors contributing to fracture non-unions

Cited by 235 publications

References 31 publications

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective

Pseudarthrosen

Humerus, Radius Ve Ulna’daki̇ Foramen Nutricium’larin Anatomi̇si̇ (Bi̇r Derleme)

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