Risk factors associated with urinary albumin excretion in African Americans

Ussai, K E; Keith, Scott W.; Pequignot, Edward; Falkner, Bonita

doi:10.1038/jhh.2010.79

Cited by 5 publications

(6 citation statements)

References 31 publications

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“…In studies investigating the association of MA with glucose levels, there were conflicting results (22,37,38). Like some of these studies, we were not able to demonstrate any correlation between fasting or postprandial glucose levels and MA in a hypertensive group.…”

Section: Discussioncontrasting

confidence: 88%

Non-Diyabetik Hipertansif Kadinlarda Mikroalbüminüri, Rezistin ve Kardiyometabolik Risk Faktörlerini Etkiler mi?

Ulu¹,

Gürsoy²,

Demirbaş³

et al. 2014

Haseki

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Hipertansiyon, obezite, insülin rezistansı ve lipid seviyeleri kardiyovasküler hastalık için risk faktörleridir. C-reaktif protein, homosistein ile kardiyovasküler risk arasındaki ilişki uzun zamandır tartışılmaktadır. Rezistin ve mikroalbüminürinin diyabetes mellitus, insülin rezistansı ve kardiyovasküler hastalık ile bağlantılı olduğu kabul edilmektedir. Çalışmamızda non-diyabetik hipertansif kadınlarda mikroalbüminüri ile antropometrik ve metabolik parametreler, C-reaktif protein, homosistein ve rezistin ilişkisini araştırmayı planladık. Yöntemler: Otuz yedi mikroalbüminürisi olmayan ile 47 mikroalbüminürisi olan non-diyabetik hipertansif kadın hastayı kapsayan randomize bir çalışma gerçekleştirdik. Gruplarımızda antropometrik ve metabolik parametreleri, C-reaktif protein, homosistein, insülin rezistans indeksi ve rezistin seviyelerini kıyasladık. Bulgular: Mikroalbüminürisi olan hipertansiflerde olmayanlara oranla C-reaktif protein, homosistein, rezistin, insülin seviyeleri ve insülin rezistans indeksi yüksek bulundu (all p<0,05). Sonuç: Non-diyabetik hipertansiflerde mikroalbüminürinin C-reaktif protein, homosistein ve rezistin seviyeleri üzerine etkisi olabileceğini bulduk. Non-diyabetik hipertansif kadınlarda insülin ve insülin rezistansı da mikroalbüminüriden etkilenebileceğini de düşünmekteyiz. (Ha se ki T›p Bül te ni 2014; 52: 172-6) Anahtar Sözcükler: Albüminüri, hipertansiyon, obezite, c-reaktif protein, homosistein, rezistin, kan şekeri, lipidler Abs tract Aim: Hypertension, obesity, insulin resistance and lipid levels are risk factors for cardiovascular disease. The association of cardiovascular risk with C-reactive protein and homocysteine has been debated for decades. Resistin and microalbuminuria are presumed to be associated with diabetes mellitus, insulin resistance and cardiovascular disease. The objective of our study was to investigate the relationship of microalbuminuria with antropometric and metabolic parameters, C-reactive protein, homocyteine and resistin in non-diabetic hypertensive females. Methods: We conducted a randomized study including 37 female non-diabetic hypertensives without microalbuminuria and 47 female non-diabetic hypertensive patients with microalbuminuria. We made comparisons of anthropometric and metabolic parameters, C-reactive protein, homocysteine, insulin resistance index and resistin between the groups. Results: C-reactive protein, homocysteine, resistin, insulin levels and homeostasis model assessment of insulin resistance were higher in hypertensives with microalbuminuria than in hypertensives without microalbuminuria (all p<0.05). Conclusion: We found that microalbuminuria may have an influence on C-reactive protein, homocysteine and resistin levels in non-diabetic hypertensives. We also think that insulin and insulin resistance may also be related with microalbuminuria in nondiabetic hypertensive female patients.

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Section: Discussioncontrasting

confidence: 88%

Non-Diyabetik Hipertansif Kadinlarda Mikroalbüminüri, Rezistin ve Kardiyometabolik Risk Faktörlerini Etkiler mi?

Ulu¹,

Gürsoy²,

Demirbaş³

et al. 2014

Haseki

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“…Plasma adiponectin levels in this study seem to be somewhat higher than adiponectin levels measured in more recent studies in our laboratory on African American participants 48. Since the samples used in this study were stored for several years there is a possibility that some evaporation of the samples could have occurred.…”

Section: Discussioncontrasting

confidence: 68%

Relationship of Adipokines With Insulin Sensitivity in African Americans

Cantarin

DeLoach

Huan

et al. 2011

The American Journal of the Medical Sciences

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Cytokines produced by adipose tissue including adiponectin have been associated with metabolic abnormalities. Objective The purpose of this study was to examine the relationship of insulin sensitivity measured by euglycemic hyperinsulinemic insulin clamp with plasma adiponectin and other adipokines in young adult African Americans. Methods Participants were relatively healthy African Americans. Anthropometric measures, blood pressure, an oral glucose tolerance test and an euglygemic hyperinsulinemic insulin clamp were performed. Insulin sensitivity measurements were adjusted for percentage of fat mass. Plasma concentrations of adiponectin, plasminogen activator inhibitor 1 (PAI-1) and interleukin 6 (IL-6) were assayed on plasma from fasting blood samples. Pearson correlation coefficients and multiple regression models were fitted to assess the association between glucose sensitivity and cytokines. Results In univariate analysis, there were statistically significant correlations of plasma adiponectin level (r = 0.19, P = 0.004), PAI-1 (r=−0.19, P=0.020) and IL-6 (r=−0.24, P<0.001) with measures of insulin sensitivity after adjustment for both fat mass and insulin clamp concentration. In multivariate analysis, adiponectin (GMR 1.15 P=0.007), PAI-1 (GMR 0.998, P=0.021) and BMI (GMR 0.95, P<0.001) were each independently associated with insulin sensitivity. For IL-6 there was no significant association with insulin sensitivity independent of obesity. Conclusion This data show a significant and independent positive correlation of adiponectin with insulin sensitivity. The relationship of IL-6 with insulin sensitivity appears to be dependent on adiposity.

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“…The association of hypertension and DM with elevated levels of MAU has been well established. 21,27,35 Several studies suggest that inflammation, insulin resistance, systemic endothelial dysfunction, increased vessel wall permeability, and leakage of lipoproteins and MAU could accelerate atherosclerosis, and disturbances in coagulation may account for the association, 8,32,36,37 but it has not yet been confirmed. These mechanisms might explain the higher MAU in individuals with DM or hypertension.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Microalbuminuria Among Middle-Aged Population of China

et al. 2013

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We assessed the prevalence of microalbuminuria (MAU) and the relationships with other cardiovascular (CV) risk factors among a middle-aged Chinese population. Data from 10 313 participants were included in our cross-sectional survey. Microalbuminuria was defined as the urine albumin to creatinine ratio of 30:300 mg/g from a single-spot morning urine sample. Microalbuminuria was found to be common in males and females (15.04% vs 10.09%) aged 35 to 64 years in this Chinese general population, especially in those with obesity, hypertension, and diabetes. Multivariate analysis found that body mass index, triglyceride, high-sensitivity C-reactive protein, alcohol consumption, hypertension, and diabetes were independently associated with MAU. Microalbuminuria may be a useful indicator for risk of CV disease in general populations.

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Risk factors associated with urinary albumin excretion in African Americans

Cited by 5 publications

References 31 publications

Non-Diyabetik Hipertansif Kadinlarda Mikroalbüminüri, Rezistin ve Kardiyometabolik Risk Faktörlerini Etkiler mi?

Non-Diyabetik Hipertansif Kadinlarda Mikroalbüminüri, Rezistin ve Kardiyometabolik Risk Faktörlerini Etkiler mi?

Relationship of Adipokines With Insulin Sensitivity in African Americans

Prevalence of Microalbuminuria Among Middle-Aged Population of China

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