Risk Factors Associated with the Incidence of Open-Angle Glaucoma: The Visual Impairment Project

Le, Anhchuong; Mukesh, Bickol N.; McCarty, Catherine A.; Taylor, Hugh R.

doi:10.1167/iovs.03-0077

Cited by 314 publications

(265 citation statements)

References 46 publications

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“…This result revealed the importance of further studies examining the CYP1A1m1 polymorphism and POAG. Le et al (2003) showed that POAG development was not related to gender, which agrees with the results of Rudnicka et al (2006). Cedrone et al (2008) observed a high prevalence of glaucoma in female patients, which was similar to a study conducted in Dalby, Sweden (Bengtsson, 1989).…”

Section: Discussionsupporting

confidence: 87%

Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma

Costa¹,

Silva²,

Frare³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The CYP1A1 gene is related to the generation of secondary metabolites that are capable of inducing DNA damage. The CYP1A1m1 polymorphism has been examined in many studies, and is located in a region near loci that have been linked to glaucoma, including the locus GLC1I. As a result, this polymorphism has been related to several diseases that are influenced by exposure to xenobiotic as well as primary open-angle glaucoma. We compared the prevalence of the CYP1A1m1 polymorphism in 152 Brazilian patients, 100 patients with primary open-angle glaucoma, and 52 normal controls using restriction fragment length polymorphism analysis. The frequency of the homozygous wild-type (w1/w1) CYP1A1 gene among patients with primary open-angle glaucoma (N = 100) was 16%, for genotype w1/m1, the frequency was 77%, and for m1/m1 it was 7%. Among the control group (N = 52), the frequency of the homozygous wild-type (w1/w1) CYP1A1 gene was 54%, the frequency of w1/m1 was 46%, and the frequency of m1/m1 was 0%. The presence of the CYP1A1m1 polymorphism may interfere with xenobiotic metabolism and exacerbate direct or indirect damage to the optic nerve. These CYP1A1m1

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Section: Discussionsupporting

confidence: 87%

Association between CYP1A1m1 gene polymorphism and primary open-angle glaucoma

Costa¹,

Silva²,

Frare³

et al. 2014

Genet. Mol. Res.

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show abstract

“…1 Some previous studies have concluded that family histories of glaucoma, severe myopia, or high IOP constitute major risk factors. 2 Of these identified risk factors, IOP has received attention for many years as a potential modifiable risk factor. [3][4][5] Although the mechanism underlying IOP elevation are not fully understood, a recent study reported associations between systemic health parameters, such as, hypertension, diabetes, and obesity indexes (eg, waist circumference and BMI) and IOP elevation.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein B: novel indicator of elevated intraocular pressure

Son

Chung

Son

2015

Eye

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Purpose Many studies have reported associations between elevated intraocular pressure (IOP) and systemic health parameters, which suggest a common mechanism links IOP elevation and various related cardiometabolic risk factors. Furthermore, according to a recent study, serum apolipoprotein B (APO B) level is a predictor of coronary artery disease. This study was undertaken to analyse the relationship between serum apolipoprotein levels and IOP.

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“…1 The well-known risk factors for glaucoma include African ethnicity, family history of glaucoma, severe myopia, and high intraocular pressure (IOP). 1,2 Of these risk factors, high IOP is one of the strongest risk factors for glaucoma, and therefore, reducing IOP may delay the development of primary open-angle glaucoma. 3,4 Metabolic syndrome (MetS) is a collection of risk factors that increases the chance of an individual developing cardiovascular disease and diabetes mellitus (DM).…”

Section: Introductionmentioning

confidence: 99%