Risk factors associated with the carotid intima-media thickness and plaques: ESPREDIA Study

Mostaza, José María; Lahoz, Carlos; Salinero-Fort, Miguel A; Laguna, Fernando Ballester; Estirado, Eva; García-Iglesias, Francisca; Alegre, Teresa González; Sabín, Concesa; López, Silvia; Cornejo, Victor; Espredia, en representación de los investigadores del estudio

doi:10.1016/j.artere.2018.03.001

Cited by 3 publications

(5 citation statements)

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“…The results of previous studies showed that all three components (IMT, carotid plaque and left ventricular hypertrophy) of ATB contributed similarly and significantly to premature mortality, suggesting that premature mortality is not driven solely by just one or two components [5,6]. The prevalence of carotid plaques (41%) was high although similar to that shown in other research studies carried out in Spain [35]. It is worth stressing that…”

Section: Discussionsupporting

confidence: 74%

“…Our study results suggest a greater relationship between the hemodynamic effect of hypertension (duration of the disease and renal dysfunction) and a high IMT value than with the former and the presence of plaques. Furthermore, the fact that both IMT and plaque largely share the same risk factors suggests that they are really two phases of the same atherosclerotic process, as pointed out by some studies [35,42,43].…”

Section: Discussionmentioning

confidence: 94%

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Subclinical atherosclerosis burden in non-diabetic hypertensives treated in primary care center: the IMTABI study

et al. 2023

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Background Identifying patients at high risk of cardiovascular disease in primary prevention is a challenging task. This study aimed at detecting subclinical atherosclerosis burden in non-diabetic hypertensive patients in a primary care centre. Methods Clinical, anthropometric and analytical data were collected from patients with hypertension who were free from clinical vascular disease and diabetes. The cardiovascular risk was assessed using the SCORE system. Subclinical atherosclerosis burden was assessed by carotid ultrasonography (intima-medial thickness [IMT] and plaque) and measurement of the ankle-brachial index (ABI). Results Out of 140 patients, 59 (42%) have carotid plaque, 32 (23%) have IMT higher than 75% and 12 (9%) have an ABI < 0.9. Total atherosclerosis burden was present in 91 (65%) of the subjects. Consequently, 59 (42%) patients were re-classified into the very high-risk category. In multivariate analyses, smoking, creatinine levels and duration of hypertension were associated with atherosclerosis burden. In contrast, only smoking and age were associated with the presence of carotid plaque. Almost 90% of patients were treated with hypotensive drugs, half of them combined several drugs and 60% were well-controlled. Only 30% received statins in monotherapy and only less than 20% had an LDL cholesterol < 100 mg/dL. Conclusions In non-diabetic hypertensive patients managed at a primary care centre, 4 out of 10 had subclinical atherosclerosis burden and were re-classified into the very high- risk category. There was clear undertreatment with lipid-lowering drugs of most LDL cholesterol inappropriate levels, according to current clinical guidelines.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 94%

Subclinical atherosclerosis burden in non-diabetic hypertensives treated in primary care center: the IMTABI study

et al. 2023

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“…Research has proven that the intima media thickness (IMT) is an effective parameter for predicting cardiovascular risk, as an increase of the IMT indicates a higher risk of atherosclerosis. [3][4][5][6][7] As can be seen in Figure 1, there are three layers in the CCA wall. From the innermost to the outermost, they are the intima, media, and adventitia.…”

Section: Introductionmentioning

confidence: 99%

Fully Automatic Measurement of Intima-Media Thickness in Ultrasound Images of the Common Carotid Artery Based on Improved Otsu’s Method and Adaptive Wind Driven Optimization

Wang

Zhang

et al. 2020

Ultrason Imaging

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The intima media thickness (IMT) of the common carotid artery (CCA) can be used to predict the risk of atherosclerosis. Many image segmentation techniques have been used for IMT measurement. However, severe noise in the ultrasound image can lead to erroneous segmentation results. To improve the robustness to noise, a fully automatic method, based on an improved Otsu’s method and an adaptive wind-driven optimization technique, is proposed for estimating the IMT (denoted as “improved Otsu-AWDO”). First, an advanced despeckling filter, i.e., “ Nagare’s filter” is used to address the speckle noise in the carotid ultrasound images. Next, an improved fuzzy contrast method (IFC) is used to enhance the region of the intima media complex (IMC) in the blurred filtered images. Then, a new method is used for automatic extraction of the region of interest (ROI). Finally, the lumen intima interface and media adventitia interface are segmented from the IMC using improved Otsu-AWDO. Then, 156 B-mode longitudinal carotid ultrasound images of six different datasets are used to evaluate the performance of the automatic measurements. The results indicate that the absolute error of proposed method is only 10.1 ± 9.6 (mean ± std in μm). Moreover, the proposed method has a correlation coefficient as high as 0.9922, and a bias as low as 0.0007. From comparison with previous methods, we can conclude that the proposed method has strong robustness and can provide accurate IMT estimations.

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“…Quando cada métrica de ICH foi avaliada individualmente, nunca ter fumado, pressão arterial ideal e colesterol total ideal foram protetores para presença de placas nas carótidas e escore de placas> 2. Nossos resultados são semelhantes aos do estudo ESPREDIA, que mostrou associação direta entre tabagismo atual, hipertensão e hipercolesterolemia com placas carotídeas(66). O estudo ESPREDIA mostrou, entretanto, uma relação direta entre diabetes melitus e placas carotídeas(66), mas nosso estudo não encontrou essa relação.…”

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“…Nossos resultados são semelhantes aos do estudo ESPREDIA, que mostrou associação direta entre tabagismo atual, hipertensão e hipercolesterolemia com placas carotídeas(66). O estudo ESPREDIA mostrou, entretanto, uma relação direta entre diabetes melitus e placas carotídeas(66), mas nosso estudo não encontrou essa relação. O ESPREDIA foi um estudo transversal com 1475 participantes, idade entre 45 e 75 anos, selecionados de maneira randômica da população noroeste de Madri.…”

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Associação entre escore de saúde cardiovascular e placas nas carótidas: análise transversal do estudo longitudinal da saúde do adulto (ELSA-Brasil)

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Agradeço a Deus pelo dom da vida Ao meu orientador professor Dr Paulo Lotufo, pela oportunidade, inspiração e grande aprendizado. O professor Lotufo nos mostra que podemos ser melhores a cada dia. Ao professor Dr. Itamar Souza Santos, pelo apoio, incentivo, orientações e amizade.A professora Dra. Isabela Bensenor e professor Dr Márcio Sommer, por toda orientação e disponibilidade. Ao professor Dr Cláudio Campi, pelo incentivo e exemplo de profissionalismo.A toda equipe do ELSA-Brasil, centro São Paulo, pelo profissionalismo e apoio.Aos colegas e amigos do HU-USP por todo incentivo e companheirismo.Aos meus pais, sogra, avó, irmãos, tios, cunhados, cunhadas e sobrinhos por todo amor e apoio. Agradecimento especial ao meu irmão Dr Pedro, grande incentivador de toda a vida, além apoio na coleta e discussão de dados. Aos meus filhos Davi(in memoriam), João e André e minha esposa Clarissa. Vocês são o meu maior amor, minha maior inspiração e fonte de incentivo. Meu eterno agradecimento a todos que contribuíram nesse trabalho , diretamente ou indiretamente. EPÍGRAFE " O otimismo é a fé em ação. Nada se pode levar a efeito sem otimismo." Helen Adams Keller, ativista social norte-americana.

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Risk factors associated with the carotid intima-media thickness and plaques: ESPREDIA Study

Cited by 3 publications

References 24 publications

Subclinical atherosclerosis burden in non-diabetic hypertensives treated in primary care center: the IMTABI study

Subclinical atherosclerosis burden in non-diabetic hypertensives treated in primary care center: the IMTABI study

Fully Automatic Measurement of Intima-Media Thickness in Ultrasound Images of the Common Carotid Artery Based on Improved Otsu’s Method and Adaptive Wind Driven Optimization

Associação entre escore de saúde cardiovascular e placas nas carótidas: análise transversal do estudo longitudinal da saúde do adulto (ELSA-Brasil)

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