Risk Factors Associated with Persistent Anterior Uveitis after Cataract Surgery

Reddy, Amit K.; Patnaik, Jennifer L; Miller, Dayton T.; Lynch, Anne M.; Palestine, Alan G.; Pantcheva, Mina B.

doi:10.1016/j.ajo.2019.02.016

Cited by 33 publications

(28 citation statements)

References 10 publications

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“…This was also true for the phacoemulsification alone group, OR=19.0 (10.7–33.9). This finding supports Reddy et al 7 report that PAU is more common after uncomplicated phacoemulsification alone in African Americans. Edmiston et al noted a significantly lower rate of PAU in Whites in comparison to African Americans following phaco/ECP.…”

Section: Discussionsupporting

confidence: 90%

“…As previously reported the higher CDE and duration of phacoemulsification alone were not significant risk factors for PAU in patients undergoing phacoemulsification only. 7 In our present study, after adjustment for ECP, CDE and duration of surgery were not associated with PAU.…”

Section: Discussionsupporting

confidence: 39%

“…However, some patients, especially African Americans, develop a more chronic or persistent anterior uveitis (PAU). 7 , 8 Edminston et al demonstrated that PAU has also been found to occur after combined phaco/ECP, particularly in African Americans. 9 However, the lack of a control group in this study did not allow for the determination of the relative contribution of the ECP to the development of PAU regardless of race.…”

Section: Introductionmentioning

confidence: 99%

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Endoscopic Cyclophotocoagulation Combined with Phacoemulsification Increases Risk of Persistent Anterior Uveitis Compared to Phacoemulsification Surgery Alone

Koduri¹,

Reddy²,

Patnaik³

et al. 2021

OPTH

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Purpose To evaluate if the addition of endoscopic cyclophotocoagulation (ECP) to uncomplicated phacoemulsification cataract extraction increases the risk of persistent anterior uveitis (PAU) compared to phacoemulsification alone. Patients and Methods Retrospective analysis of patients who had either phacoemulsification alone or combined with endoscopic cyclophotocoagulation from January 1, 2014 to December 31, 2017. Visual acuity, intraocular pressure, presence of anterior chamber cells, and steroid usage were analyzed pre- and post-operatively. Patient eyes with a history of uveitis, autoimmune disease, complicated cataract surgery, combined surgery other than ECP, and less than 3 months of follow-up were excluded. Results This study consisted of 4423 eyes from 2903 patients, meeting the inclusion criteria (phacoemulsification only group n=4242 and phacoemulsification/ECP group n=181 eyes). PAU developed in 14.9% in the phacoemulsification with ECP group compared to 1.7% who had phacoemulsification alone. White patients had a 17.9 (95% CI: 7.8–41.1, p<0.0001) increased odds of developing persistent anterior uveitis with a combined procedure compared to phacoemulsification only, while Non-white patients had a 5.8 (95% CI: 2.8–12.1, p<0.0001) increased odds. Despite the higher odds ratio in White patients, this group had a significantly lower rate of PAU compared to Non-white patients after phacoemulsification/ECP. Conclusion The addition of endoscopic cyclophotocoagulation to phacoemulsification significantly increases the risk of developing PAU in the post-operative period compared to phacoemulsification alone.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 39%

Section: Introductionmentioning

confidence: 99%

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Endoscopic Cyclophotocoagulation Combined with Phacoemulsification Increases Risk of Persistent Anterior Uveitis Compared to Phacoemulsification Surgery Alone

Koduri¹,

Reddy²,

Patnaik³

et al. 2021

OPTH

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“…The study prospectively received approval from the Colorado Multiple Institutional Review Board (COMIRB Protocol 18-0122), and all research conformed to the tenets of the Declaration of Helsinki. In a manner similar to our previous publications [ 3 ], medical charts were reviewed, and data were entered into Research Electronic Data Capture (REDCap; Vanderbilt University, Nashville, Tennessee) database, a secure, web-based application. The registry includes patient demographic information, medical history, preoperative medication history, intraoperative and postoperative complications, and preoperative and postoperative eye examinations.…”

Section: Methodsmentioning

confidence: 99%

Timing of Quiescence and Uveitis Recurrences After Cataract Surgery in Patients with a History of Uveitis

et al. 2021

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Introduction: In patients with a history of uveitis, a 60-90-day period of quiescence prior to cataract surgery has been historically recommended. These recommendations were based mostly on expert opinion. The purpose of this study was to further examine and understand uveitis quiescence timing and outcomes of eyes that do have a recurrence of uveitis after cataract surgery. Methods: Patients with a history of uveitis undergoing cataract surgery at the University of Colorado Sue-Anschutz Rodgers Eye Center from 2014 to 2018 were studied. Main outcome measures were best corrected visual acuity (BCVA) at 6 months, intraocular pressure (IOP) at 6 months, and recurrences of uveitis within 90 days of surgery. Timing of cataract surgery in relation to preoperative uveitis quiescence was recorded.Results: A total of 149 eyes from 114 patients were included. Uveitis recurrence was seen in 31 (20.8%) of the 149 eyes with a history of uveitis undergoing phacoemulsification. The mean logMAR change or improvement in vision was 0.429 in eyes with a recurrence of uveitis, and 0.318 in eyes without, a difference that was not statistically significant (p = 0.292). Eyes with a recurrence of uveitis displayed higher IOP at 6 months compared to eyes without a recurrence, at 16.1 versus 13.0 mmHg respectively (p = 0.0009). Eyes that were quiescent for 30 days or less were more likely to have a uveitis recurrence (OR 6.11, 95% CI 2.48-15.06, p = 0.0001). Conclusions: Our study shows that a quiescence period of at least 30 days is beneficial in reducing uveitis recurrence after cataract surgery. It is unclear what the long-term consequences of a uveitis recurrence after cataract surgery are, though it appears there may be elevated IOP in patients with recurrences, and thus patients with a history of uveitis should be counseled carefully about this potential risk.

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“…Other complications leading to decreased post-operative vision are, secondary glaucoma, pupillary capture, posterior capsular opacification and retinal scar. 3 Main causes of traumatic cataract are direct penetrating injury to the lens, concussion or blunt injury. Some rare causes are Electric shock and lightning and ionizing irradiation to ocular tumors.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the factors affecting visual prognosis in patients with traumatic cataract

Dhanya¹,

Abraham²,

Nair³

2020

Int J Res Med Sci

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Background: Ocular trauma is a major cause of visual impairment throughout the world, although little is known about the factors that affect the visual outcome in traumatic cataract in developing countries. The objective of the study was to find out the associated ocular injuries and the factors affecting final visual outcome of patients with traumatic cataract.Methods: This prospective-hospital based study was conducted on 50 patients of traumatic cataract in the department of ophthalmology government medical college, Ernakulam, from January 2009 to December 2011. Patients were managed with lens extraction and intraocular lens implantation. Regular follow up of patients was done and best corrected visual acuity (BCVA) and post-operative complications were assessed at the end of six months.Results: Our study showed that majority (64%) of patients were in the age group of <40 years with male preponderance. visual outcome was significantly better in younger age group (<20 years) than the older group (>20 years) (p=0.03). There was no significant difference in final visual outcome of traumatic cataracts caused by penetrating or blunt trauma (p=0.73). Corneal tear was most common associated ocular damage followed by uveitis, lens matter in anterior chamber.Conclusions: Age of the patient affects final visual outcome after surgical treatment of traumatic cataract but type of trauma (blunt/penetrating) had no significant effect on final visual outcome. Corneal tear was most common associated ocular damage.

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Risk Factors Associated with Persistent Anterior Uveitis after Cataract Surgery

Cited by 33 publications

References 10 publications

Endoscopic Cyclophotocoagulation Combined with Phacoemulsification Increases Risk of Persistent Anterior Uveitis Compared to Phacoemulsification Surgery Alone

Endoscopic Cyclophotocoagulation Combined with Phacoemulsification Increases Risk of Persistent Anterior Uveitis Compared to Phacoemulsification Surgery Alone

Timing of Quiescence and Uveitis Recurrences After Cataract Surgery in Patients with a History of Uveitis

Evaluation of the factors affecting visual prognosis in patients with traumatic cataract

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