Risk factors associated with mortality in patients infected with influenza A/H1N1 in Mexico

Mata-Marín, Luis Alberto; Mata‐Marín, José Antonio; Vásquez-Mota, Velasco Claudia; Arroyo-Anduiza, Carla Ileana; Gaytán-Martı́nez, Jesús; Manjarrez-Tellez, Bulmaro; Ochoa-Carrera, Luis Alberto; Sandoval-Ramírez, Jorge Luis

doi:10.1186/s13104-015-1349-8

Cited by 25 publications

(29 citation statements)

References 19 publications

(27 reference statements)

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“…In the review of studies that provided estimates adjusted for the presence of other factors known to impact the risk of severe outcomes for people ill with influenza, we found that the risk estimate was heterogeneous and not consistently greater or less than the pRR estimated with this meta‐analysis …”

Section: Resultsmentioning

confidence: 78%

Risk factors for serious outcomes associated with influenza illness in high‐ versus low‐ and middle‐income countries: Systematic literature review and meta‐analysis

Coleman

Fadel

Fitzpatrick

et al. 2017

Influenza Resp Viruses

102

105

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AimTo determine factors associated with a serious outcome (hospital admission or severe outcome: critical care or death) and associated with illness caused by laboratory‐confirmed influenza, with a specific interest in low‐ and middle‐income countries (LMIC).MethodDatabases were searched on 11 March 2016 for reports of influenza and factors associated with mortality or morbidity in humans, with no language restrictions. Pooled risks were estimated using random‐effects models.ResultsDespite the heterogeneity of results across studies, known risk factors for serious disease were associated with both hospital admission and severe outcomes (critical care and/or death). In LMIC, but not in high income countries (HIC), pregnant women, people with HIV/AIDS and children < 5 years old (compared with older children) were at increased risk of a severe outcome. Also, although all patients with neurological conditions were at higher risk of severe outcomes than those without, children were at higher risk than adults and children who lived in a LMIC were at significantly higher risk than those living in HIC. Adults were more likely than children to suffer a severe outcome if they had diabetes or a hematologic condition, were obese or had liver disease. Asthma is a risk factor for hospital admission but not for severe outcomes.ConclusionKnown risk factors for serious disease remain important predictors of hospital admission and severe outcomes with few differences between HIC and LMIC countries. These differences likely reflect differences in health‐seeking behaviours and health services, but high heterogeneity between studies limits conclusions about the effect size.

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Section: Resultsmentioning

confidence: 78%

Risk factors for serious outcomes associated with influenza illness in high‐ versus low‐ and middle‐income countries: Systematic literature review and meta‐analysis

Coleman

Fadel

Fitzpatrick

et al. 2017

Influenza Resp Viruses

102

105

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“…It is known that patients with different comorbid conditions such as diabetes mellitus, chronic cardiovascular and pulmonary diseases, immunosuppressive conditions, adult patients and other conditions are at higher risk of developing severe clinical course of the disease and lethal outcome [5]. Although the influenza virus is primarily a respiratory pathogen, the severe clinical forms of the disease are manifested as systemic infections with multisystem organ affection, and even 10-30% of the diseased need intensive treatment [6,7]. Pneumonia, delayed antiviral treatment, severe hypoxemia and multisystem organ failure are most commonly referred as leading risk factors for lethal outcome [8].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Lethal Outcome in Patients with Severe Form of Influenza

Cvetanovska¹,

Milenkovik²,

Uroshevik³

et al. 2016

Prilozi

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Introduction: Clinical manifestations of influenza range from relatively mild and self-limiting respiratory infections to severe clinical manifestations with significant morbidity and mortality. The awareness of predictive indicators for the lethal outcome of influenza is of particular significance in making timely and exact decision for adequate treatment. The aim of this study was to identify the factors in patients with a severe form of influenza, resulting in lethal outcome. Materials and methods:The investigation was a prospective group comparison conducted at the University Clinic for Infectious Diseases in Skopje, R. Macedonia in the period from January 01, 2012 to January 01, 2015. The study included adult patients with a severe form of influenza who were further categorized into a group of either survived patients or a group of deceased patients. Demographic, clinical and biochemical data were noted in all patients included in the study on admission. The variables of the univariate analysis that showed a significant difference in terms of the outcome were used for creating multivariate logistic and regression analysis of the outcome as dependent factors. The independent predictors for lethal outcome in severe cases of influenza were identified by using logistic regression. Results: The study included 87 patients with a severe form of clinical and laboratory confirmed influenza. The patients were divided in two groups: survived (n = 75) and deceased (n = 75). The overall mortality was 13.79%. Multivariate analysis conducted on admission to hospital identified cardiovascular comorbid diseases (p = 0.014), urea values higher than 8.3 U/L (p = 0.045) and SAPS score (p = 0.048) as independent predictors of the outcome in patients with severe form of influenza. Influenza patients with cardiovascular diseases had 2.024 times greater risk of death from influenza in comparison to the patients having influenza without history of such a disease (OR = 2.024 95% CI 1.842-17.337). Patients with serum urea values higher than 8.3 U/L had 1.89 times higher chance of death compared to patients with normal values (OR = 1.89 95% CI 1.091-11.432). The increase of the SAPS score in one point increased the chance of death in patients with influenza by 1.2% (OR = 1.12 95% CI 1.01-2.976). The ROC analysis indicated that cardiovascular diseases, increased urea values and SAPS score in combination act as a good prognostic model for the fatal outcome. The global authenticity of this predictive model to foresee lethal outcome amounts to 80%, sensitivity being 82%, and specificity 70%. Conclusion: Cardiovascular diseases, increased values of urea over 8.3 mmol/l and SAPS score are independent predictive indicators for lethal outcome in severe influenza. Early identification of the outcome predictors in patients with severe influenza will allow implementation of adequate medical treatment and will contribute to decreasing of mortality in patients with severe form of influenza.

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“…In the present study, comorbidities such as diabetes and underlying pulmonary diseases did not have a significant effect on the increase in mortality. However, the presence of diabetes was reported as a mortality risk factor in some studies from China (17). In other studies, obesity and asthma were also reported as risk factors for this kind of infection (18).…”

Section: Discussionmentioning

confidence: 97%

Outcomes of patients with definitive diagnosis of influenza a (H1N1) virus infection admitted to affiliated hospitals of Babol University of Medical Sciences, 2015-2016

Ebrahimpour¹,

Babazadeh²,

Sadeghi–Haddad–Zavareh³

et al. 2019

Acta fac medic Naissensis

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S U M M A R YWith the aim to analyze the clinical manifestations and outcomes of influenza, we evaluated the symptoms of proven H1N1 cases and outcomes of patients admitted to hospitals Babol University of Medical Sciences during 2015 -2016.In this descriptive cross-sectional study, we included patients diagnosed with influenza-like illness (ILI) from October 2015 to March 2016 at hospitals affiliated to Babol University of Medical Sciences.To diagnose H1N1 infection, reverse transcription-polymerase chain reaction (RT-PCR) was performed on nasopharyngmeal swabs collected from the patients.In the current study, 123 patients were admitted due to ILI.The RT-PCR result was positive in 47.2% of patients. Symptoms such as productive cough (35.3%), sore throat (51.4%), headache (50%), dyspnea (53.2%) were comparable between PCR + H1N1 confirmed cases and H1N1 negative cases. Among the H1N1 confirmed cases, 48.3% were admitted to the intensive care unit (ICU) because of the disease severity, and 20.7% died even after receiving the therapy for several days. Among the infected cases, 20 women were pregnant, out of which three subjects died. Mortality was mostly observed in the age ˃ 50 (39%) (p = 0.03). Myalgia was significantly less observed in the group with mortality compared to other age groups (6.5% vs. 93.5%) (p = 0.005). The mortality rate of patients who received vancomycin was found to be significantly low (40%) (p = 0.01). In mortality group, the frequency of patients with creatinine levels > 1.5 mg/dL was significantly higher (58.3%) (p = 0.009) than in the group of patients who recovered. The average length of hospitalization in the mortality group was significantly longer than the hospitalization of the recovered group (11.1 days vs. 6.3 days) (p = 0.02).The current study reported a mortality rate that was more than expected in comparison to previous seasons. Our study results suggest that the absence of typical influenza symptoms such as myalgia should not cause a O r i g i n a l a r t i c l e Acta facultatis medicae Naissensis 2019; 36(4):356-364 357 delay in the diagnosis of this infection in cold seasons.

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Risk factors associated with mortality in patients infected with influenza A/H1N1 in Mexico

Cited by 25 publications

References 19 publications

Risk factors for serious outcomes associated with influenza illness in high‐ versus low‐ and middle‐income countries: Systematic literature review and meta‐analysis

Risk factors for serious outcomes associated with influenza illness in high‐ versus low‐ and middle‐income countries: Systematic literature review and meta‐analysis

Factors Associated with Lethal Outcome in Patients with Severe Form of Influenza

Outcomes of patients with definitive diagnosis of influenza a (H1N1) virus infection admitted to affiliated hospitals of Babol University of Medical Sciences, 2015-2016

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