Risk factors associated with liver steatosis and fibrosis in chronic hepatitis B patient with component of metabolic syndrome

Cai, Shaohang; Ou, Zejin; Liu, Duan; Liu, Huan; Liu, Ying; Wu, Xiaolu; Yu, Tao; Peng, Jie

doi:10.1177/2050640617751252

Cited by 50 publications

(50 citation statements)

References 30 publications

(49 reference statements)

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“…FibroScan examinations were performed by 2 operators trained according to the manufacturer's handbook. More details of the procedure have been described previously . A result was considered valid only if the FibroScan produced at least 10 successful shots and the success rate was 60% or higher, with an interquartile median ratio lower than 30%.…”

Section: Methodsmentioning

confidence: 99%

“…The pathologic characteristics of liver cirrhosis include degeneration and necrosis of hepatocytes, replacement of liver parenchyma by fibrotic tissues and regenerative nodules, and loss of liver function . Complications of liver cirrhosis include ascites, bleeding from esophageal varices, hepatic encephalopathy, and severe jaundice . Therefore, it is very important to detect the progression of liver fibrosis for choosing appropriate interventions to prevent progression to liver cirrhosis .…”

mentioning

confidence: 99%

“…Due to the increasing effort to develop accurate and noninvasive assessments for evaluating liver fibrosis, transient elastography (FibroScan; Echosens, Paris, France) was invented as a new method to detect liver fibrosis . FibroScan is a noninvasive and repeatable method for the detection of liver fibrosis.…”

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confidence: 99%

“…8,9 Complications of liver cirrhosis include ascites, bleeding from esophageal varices, hepatic encephalopathy, and severe jaundice. [10][11][12][13] Therefore, it is very important to detect the progression of liver fibrosis for choosing appropriate interventions to prevent progression to liver cirrhosis. 14,15 Currently, liver biopsy is the reference standard for assessing liver fibrosis.…”

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confidence: 99%

“…18,19 Due to the increasing effort to develop accurate and noninvasive assessments for evaluating liver fibrosis, transient elastography (FibroScan; Echosens, Paris, France) was invented as a new method to detect liver fibrosis. 20 FibroScan is a noninvasive and repeatable method for the detection of liver fibrosis. Since the detection range of liver tissue for FibroScan is 100 times larger than that for liver biopsy, FibroScan is more accurate for detection of the degree of liver fibrosis, as reported previously.…”

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confidence: 99%

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Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

Sun

et al. 2018

J of Ultrasound Medicine

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Objectives To evaluate the dynamic changes of the aspartate aminotransferase (AST)‐to‐platelet ratio and transient elastography (FibroScan; Echosens, Paris, France) in predicting a histologic response in patients with chronic hepatitis B (CHB) after entecavir treatment. Methods A total of 148 patients with CHB were enrolled. Patient information was collected. All patients received liver biopsy and FibroScan before and after 96 weeks of entecavir treatment. Results Baseline liver biopsy results showed that there were 7 patients without liver fibrosis (fibrosis stage F0; 4.7%), 51 patients with mild liver fibrosis (F1; 34.5%), and 90 patients with advanced liver fibrosis (>F1; 60.9%). The liver stiffness value and AST‐to‐platelet ratio increased significantly as the METAVIR score of the patients increased from F0 to F4 (P < .001). After antiviral therapy for 96 weeks, the average liver stiffness value measured by FibroScan and the AST‐to‐platelet ratio showed a significant decrease. When we use a decreased liver stiffness value to predict a histologic response, the area under the receiver operating characteristic curve was 0.70 (95% confidence interval, 0.61–0.79; P < .001), and the sensitivity and specificity were 74.3% and 68.8%, respectively. The decrease of the AST‐to‐platelet ratio also could predict the histologic response of patients with CHB; the area under the receiver operating characteristic curve was 0.77 (95% confidence interval, 0.69–0.86; P < .001) with sensitivity of 76.2% and specificity of 70.2%. A multivariate analysis indicated that a high hepatitis B virus DNA viral load (odds ratio, 1.44; P = .04) and high METAVIR score (odds ratio, 1.38; P = .02) were independent risk factors for the histologic response. Conclusions Both the AST‐to‐platelet ratio and FibroScan value can effectively predict a histologic response in patients with CHB during entecavir treatment. Therefore, they can be used to monitor these patients during antiviral treatment to avoid multiple liver biopsies.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

Sun

et al. 2018

J of Ultrasound Medicine

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HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma

Wang

et al. 2023

Cancer Medicine

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Background Hepatitis B core antibody (HBcAb) positivity is considered a prior hepatitis B virus (HBV) infection. However, little is known about the effect of HBcAb positivity on surgical safety for hilar cholangiocarcinoma (hCCA). The present study aims to investigate the role of HBcAb positivity on postoperative complications of hCCA. Methods A retrospective analysis was performed on the status of HBcAb positivity, liver fibrosis, perioperative surgical complications, and long‐term outcomes of hCCA patients with Hepatitis B surface antigen (HBsAg) negativity who underwent surgical treatment in Tongji Hospital from April 2012 to September 2019. Results HBcAb positivity with negative HBsAg occurs in 137 hCCA patients (63.1%). A total of 99 hCCA patients with negative HBsAg underwent extended hemihepatectomy, of whom 69 (69.7%) and 30 (30.3%) were HBcAb‐positive and HBcAb‐negative, respectively. Significant fibrosis was detected in 63.8% of the patients with HBcAb‐positive, which was markedly higher than those with HBcAb‐negative (36.7%) ( p = 0.016). The postoperative complications and 90‐day mortality rates were 37.4% (37/99) and 8.1% (8/99), respectively. The incidence of postoperative complications in HBcAb‐positive patients (44.9%) was significantly higher than that in HBcAb‐negative patients (20.0%) ( p = 0.018). All the patients who died within 30‐day after surgery were HBcAb‐positive. Multivariate analysis showed that the independent risk factors for complications were HBcAb positivity, preoperative cholangitis, portal occlusion >15 min, and significant fibrosis. There were no significant differences in recurrence‐free survival (RFS) and overall survival (OS) between HBcAb‐positive and HBcAb‐negative patients ( p = 0.642 and p = 0.400, respectively). Conclusions HBcAb positivity is a common phenomenon in hCCA patients from China, a country with highly prevalent HBcAb positivity. The status of HBcAb‐positive markedly increases the incidence of postoperative complications after extended hemihepatectomy for hCCA patients.

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Risk factors for non-alcoholic fatty liver disease-associated hepatic fibrosis in type 2 diabetes patients

et al. 2019

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Risk factors associated with liver steatosis and fibrosis in chronic hepatitis B patient with component of metabolic syndrome

Abstract: For chronic hepatitis B patients with coexisting components of metabolic syndrome, stratification by independent risk factors for nonalcoholic fatty liver disease and fibrosis can help with management of their disease.

Cited by 50 publications

References 30 publications

Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

HBcAb positivity increases the risk of postoperative complications after extended hemihepatectomy for hilar cholangiocarcinoma

Risk factors for non-alcoholic fatty liver disease-associated hepatic fibrosis in type 2 diabetes patients

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