“… 1 The prevalence of ACEi-induced AE has been reported as 28% to 30%. 2 AE is believed to be caused by plasma extravasation secondary to increased vascular permeability within the dermis, subcutaneous, or submucosal tissue. 3 Activation of the kallikrein-kinin system and the classic complement pathway results in the release of inflammatory mediators that lead to vasodilation.…”