Risk factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic at Felegehiwot referral hospital, Northwest Ethiopia, 2018: an institution based cross sectional study

Gedefaw, Getnet; Waltengus, Fikadu; Akililu, Almaz; Gelaye, Kihinetu

doi:10.1186/s13104-019-4561-0

Cited by 28 publications

(36 citation statements)

References 16 publications

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“…. Twenty-three of the studies included in the final analysis were cross-sectional [11,14,23,24,[29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. The studies used health facilitybased HBV infection data among pregnant women which were collected from 2002 to 2018 in the respective health institutions.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The studies used health facilitybased HBV infection data among pregnant women which were collected from 2002 to 2018 in the respective health institutions. Seven articles were conducted at the Southern Nations, Nationalities, and Peoples' Region (SNNPR) [11,14,29,31,35,39,47], five in Amhara region [23,24,30,32,36], five in Oromia region [33,37,38,41,44], and three in Addis Ababa [34,41,42], whereas one in Tigray [46], Harar [43], and Gambella [45]. The sample size of included studies ranges from a minimum of 165 pregnant women in SNNPR [39] to 580 in Oromia [38].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Sixteen studies, 4910 pregnant women, were included in this category of metaanalysis [11,23,24,[29][30][31][32][33][34][35][41][42][43][44][45]. Seven of the included studies [11,32,34,[41][42][43][44] showed a significant association between history of blood transfusion and a higher risk of HBV infection. The pooled meta-analysis showed higher odds of HBV infection among pregnant women who had a history of blood transfusion than those who had no history of blood transfusion, OR = 5:71 (95%CI = 3:25, 10.04).…”

Section: History Of Blood Transfusionmentioning

confidence: 99%

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Hepatitis B Virus Infection and Its Determinants among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis

Alemu

Zeleke

Aynalem

et al. 2020

Infectious Diseases in Obstetrics and Gynecology

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Background. Hepatitis B virus (HBV) is an infectious and a global public health problem. The prevalence of HBV infection among pregnant women is between 2.3% and 7.9%. HBV infection during pregnancy is associated with prenatal transmission to the fetus. HBV has an effective vaccine which reduces up to 96% of the transmission. Although different studies were conducted in Ethiopia, none of them showed the national prevalence of HBV infection among pregnant women. Therefore, this study was conducted to determine the pooled prevalence of HBV and its associated factors in Ethiopia. Methods. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for articles. All observational published studies were retrieved using relevant search terms in Google Scholar, African Online Journal, CINAHL, and PubMed databases. Newcastle-Ottawa assessment checklist for observational studies was used for critical appraisal of the included articles. The meta-analysis was done with STATA version 14 software. The I2 statistics were used to test heterogeneity whereas Begg’s and Egger’s tests were used to assess publication bias. Odds ratio (OR) with a 95% confidence interval (CI) was presented using the forest plot. Results. A total of twenty-three studies were included in this systematic review and meta-analysis. The pooled prevalence of HBV in Ethiopia was 4.75% (95% CI: 4.06, 5.44). The subgroup analysis showed a higher prevalence of HBV infection among pregnant women in Gambella (7.9%) and the lowest in Southern Nations, Nationalities, and Peoples’ Region (SNNPR) (2.3%). Associated factors with HBV infection include history of multiple sexual partner (OR=6.02 (95%CI=3.86, 9.36)), blood transfusion history (OR=5.71 (95%CI=3.25, 10.04)), abortion history (OR=3.58 (95%CI=2.10, 6.09)), and history of body tattoo (OR=2.83 (95%CI=1.55, 5.17)). Conclusions. HBV infection among pregnant women is a common public health problem in Ethiopia. Multiple sexual partners, abortion history, blood transfusion history, and body tattoo were significantly associated with HBV infection. Policies and strategies should focus on factors identified in this study to improve the prevention of HBV among pregnant women.

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: History Of Blood Transfusionmentioning

confidence: 99%

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Hepatitis B Virus Infection and Its Determinants among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis

Alemu

Zeleke

Aynalem

et al. 2020

Infectious Diseases in Obstetrics and Gynecology

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“…For example, a retrospective study in Cameroon found a significant relationship between occupation [10] and age [6,11], and HBV infection among pregnant women [11]. In Nigeria, Anaedobe, Fowotade [12], revealed that pregnant women with multiple sexual partners [6,10,[13][14][15] and those who experienced early sexual debut were more likely to be infected with HBV. Other risk factors include marital status, history of abortion, blood transfusion and surgery, family history of HBV infection, and alcohol intake [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…In Nigeria, Anaedobe, Fowotade [12], revealed that pregnant women with multiple sexual partners [6,10,[13][14][15] and those who experienced early sexual debut were more likely to be infected with HBV. Other risk factors include marital status, history of abortion, blood transfusion and surgery, family history of HBV infection, and alcohol intake [10][11][12][13][14][15][16]. However, other studies in sub-Saharan Africa including Ghana, found no significant association between participants' characteristics and HBV positivity [8,9].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Hepatitis B virus infection and associated factors among pregnant women at Korle-Bu Teaching Hospital, Ghana

Dortey¹,

Anaba

Lassey

et al. 2020

PLoS ONE

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Introduction Hepatitis B virus infection is a global public health problem. Though, the disease is endemic in sub-Saharan Africa, little is known about its epidemiology among pregnant women in Ghana. This study sought to determine the seroprevalence of Hepatitis B virus infection and associated factors among pregnant women attending antenatal care at Korle-Bu Teaching Hospital; Ghana's largest hospital. Methods We conducted a facility-based cross-sectional survey among 232 antenatal attendants. Participants were recruited using systematic random sampling technique and screened with HBsAg Rapid Test. Data was analyzed with the aid of Statistical Package for Social Sciences (SPSS), version 23.0. Results were presented using descriptive statistics, Fisher's Exact test and Logistic Regression analysis. Results Two hundred and twenty-one (221) of the total sample (n = 232) agreed to participate in this study; representing a response rate of 95%. The mean age of the participants was 31 years and standard deviation of 5.3. The mean gestational period at recruitment was 28 weeks and standard deviation of 6.8. Majority of the participants were married (83.3%), parous (69.6%), educated (91.4%) and employed (90.5%). The prevalence of HBsAg was 7.7%. We found no significant association between socio-demographic characteristics of the participants and HBV infection. Conclusion Seroprevalence of 7.7% indicates moderate endemicity. Socio-demographic characteristics did not influence HBV infection among pregnant women attending antenatal care at Korle

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Seroprevalence of Hepatitis B Virus Infection, Mother-To-Child Transmission, and Associated Risk Factors Among Delivering Mothers in Tigray Region, Northern Ethiopia: a Cross-Sectional Study

et al. 2020

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Introduction High prevalence of hepatitis B virus (HBV) infection among pregnant women is the primary source of infection for their children and the general population. Mother-to-child transmission (MTCT) is the primary mode of transmission in endemic areas like Ethiopia. The aim of this study was to determine the prevalence of HBV infection, rate of MTCT, and associated risk factors among delivering mothers. Methods This health facility-based cross-sectional study was conducted in four public hospitals of the Eastern zone of Tigray among 473 delivering mothers. Structured questionnaires and laboratory results were used to collect the data. The data were checked for completeness and entered into EpiData manager version 4.6.0.0. Then the data were exported to Statistical Package for Social Sciences (SPSS) version 23. The odds ratio, along with a 95% confidence interval, was estimated to identify predictors of HBV infection using multivariable logistic regression analysis. Significant association was considered at p < 0.05. Results A total of 473 mothers were enrolled, and the response rate was 100%. The prevalence of HBV infection among the mothers and the rate of MTCT of the infection were 11.6% and 30.9%, respectively. History of home delivery [adjusted odds ratio (AOR) = 4.5, 95% confidence interval (CI) (2, 10.6)], history of hospital admission [AOR = 5, 95% CI (2.2, 11.5)], working at health facility [AOR = 5.4, 95% CI (1.4, 20.7)], body tattoos [AOR = 5.8, 95% CI (2.4, 13.6)], sharing personal care materials [AOR = 3.8, 95% CI (1.4, 9.9)], insufficient knowledge [AOR = 5.6, 95% CI (1.6, 19)], and having human immunodeficiency virus (HIV) [AOR = 5.1, 95% CI (1, 26.2)] were significantly associated with HBV infection. Conclusion HBV infection among delivering women is becoming highly endemic, and the rate of MTCT was high. Therefore, administering hepatitis B vaccine to all neonates within 24 h of birth is mandatory to prevent MTCT of HBV infection and related complications. Furthermore, health education and dissemination of information about HBV for the pregnant mothers are needed to reduce HBV infection and vertical transmission in Ethiopia.

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Risk factors associated with hepatitis B virus infection among pregnant women attending antenatal clinic at Felegehiwot referral hospital, Northwest Ethiopia, 2018: an institution based cross sectional study

Cited by 28 publications

References 16 publications

Hepatitis B Virus Infection and Its Determinants among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis

Hepatitis B Virus Infection and Its Determinants among Pregnant Women in Ethiopia: A Systematic Review and Meta-Analysis

Seroprevalence of Hepatitis B virus infection and associated factors among pregnant women at Korle-Bu Teaching Hospital, Ghana

Seroprevalence of Hepatitis B Virus Infection, Mother-To-Child Transmission, and Associated Risk Factors Among Delivering Mothers in Tigray Region, Northern Ethiopia: a Cross-Sectional Study

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