Risk factors associated with hepatitis C virus infection in Taiwanese government employees

Chang, H. C.; Yu, Miao; Lu, Chih-Feng; Chiu, Yueh‐Hsia; Chen, C. J.

doi:10.1017/s0950268801005362

Cited by 16 publications

(17 citation statements)

References 35 publications

(44 reference statements)

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“…These issues are taboo, and therefore not usually investigated by researchers or tend to be denied by the participants when addressed. The positive association of HCV seropositivity with marriage in aggregated studies provides further evidence for sexual transmission of HCV between spouses. However, this could be confounded by sharing many other exposures or exposure to a common source of infection .…”

Section: Discussionmentioning

confidence: 99%

A comprehensive hepatitis C virus risk factors meta‐analysis (1989–2013); Do they differ in Egypt?

El‐Ghitany

Wahab

El‐Wahab

et al. 2014

Liver International

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Section: Discussionmentioning

confidence: 99%

A comprehensive hepatitis C virus risk factors meta‐analysis (1989–2013); Do they differ in Egypt?

El‐Ghitany

Wahab

El‐Wahab

et al. 2014

Liver International

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“…These results raised concerns about the true geographic extent of HBV infection in this area. In addition, although the seroprevalence of HCV antibody (anti-HCV) nationwide is comparable with that in Western countries, several townships that are widely endemic for HCV infection have been discovered in southern Taiwan as a result of the anti-HCV test as well as efforts of public health personnel over the past two decades [5][6][7][8][9][10][11][12][13][14]. Therefore, a wide and comprehensive investigation is needed to assess the seroprevalence characteristics of viral hepatitis in southern Taiwan.…”

Section: Hepatitis B Virus (Hbv) and Hepatitis C Virus (Hcv)mentioning

confidence: 99%

Viral Hepatitis Infections in Southern Taiwan: A Multicenter Community‐based Study

Yang

Lin

Huang

et al. 2010

The Kaohsiung J of Med Scie

103

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Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are major causes of liver disease in Taiwan and have a great impact on the health of this country. This study investigated the seroprevalence of HBV and HCV in southern Taiwan. Screening programs were performed from September 1999 to August 2005 for community-based surveillance of liver disease. A total of 28,797 adults from southern Taiwan, including Kaohsiung City (n = 14,036), Kaohsiung County (n = 7,713), and Pingtung County (n = 7,048) were participated. The mean age was 50.3 ± 14.6 years (range, 20-97 years), with 41.0% were men. Hepatitis B surface antigen (HBsAg), antibody to HCV (anti-HCV), and liver function tests were performed. Among the 28,797 adults, the prevalence of HBsAg(+) was 15.1% and that for anti-HCV(+) was 8.6%. The seroprevalence of HBsAg in Kaohsiung County was 18.2%, which was higher than in Kaohsiung City (14.7%, p < 0.001) or Pingtung County (12.5%, p < 0.001). The seroprevalence of anti-HCV in Kaohsiung County was 17.2%, which was higher than in the other regions (Kaohsiung City = 5.8%, p < 0.001; Pingtung County = 4.6%, p < 0.001). The prevalence of dual HBsAg and anti-HCV was 1.1% (323 patients). Tzukuan Township in Kaohsiung County was endemic for HBsAg (19.1%, 1,026/5,375 patients), anti-HCV (22.4%, 1,203/5,375 patients), and dual HBsAg/anti-HCV (3.6%, 191/5,375 patients). Subjects with anti-HCV(+) were older and had higher alanine transaminase levels than their HBsAg(+) counterparts (p < 0.001 and p < 0.001, respectively). The current study shows the epidemiological characteristics of HBV and HCV infections among adults in southern Taiwan. Viral hepatitis infections remain widely endemic in this region.

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“…Unfortunately, illegal medical services (such as the use of nondisposable needles as well as sharing syringes and fl uid for injection) are still offered in Taiwan, which may spread HCV infection [14,19,20] . Chronic HCV infection can result in cirrhosis and HCC 20 and 30 years after the transmission through transfusion [21] .…”

Section: Introductionmentioning

confidence: 99%

Viral Etiology of Hepatocellular Carcinoma and HCV Genotypes in Taiwan

Lee

Hung²,

Lu³

et al. 2005

Intervirology

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Etiologic variations of hepatocellular carcinoma (HCC) exist in different geographic areas of the world. Hepatitis B virus infection is associated with HCC. However, hepatitis C virus (HCV) infection plays an increasingly more important role in the development of HCC and is associated with more than 30% of HCC in Taiwan. The prevalence of HCV infection and HCV genotypes vary in different geographic areas. The prevalence of HCV genotype 1b (HCV-1b) was around 50–70% in Taiwan and even varied in different townships. In addition to host factors, HCV genotypes may be associated with the development of HCC. In our study, the prevalence of HCV-1b in patients with HCC was significantly higher than in those with liver cirrhosis and chronic hepatitis; multivariate analysis revealed that the disease severity was significantly correlated with age and HCV-1b. Furthermore, HCV-1b was associated with a lower response rate to interferon (IFN) therapy than HCV-2. Our study has demonstrated that mutations in the IFN sensitivity-determining region, spanning nucleotides 2,209–2,248 in the NS5A region, correlate with the sustained virological response to combination therapy with IFN and ribavirin in patients with chronic HCV-1b infection in Taiwan. A third-generation enzyme immunoassay for antibody to HCV can be used to predict viremia and monitor the virological response.

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Risk factors associated with hepatitis C virus infection in Taiwanese government employees

Cited by 16 publications

References 35 publications

A comprehensive hepatitis C virus risk factors meta‐analysis (1989–2013); Do they differ in Egypt?

A comprehensive hepatitis C virus risk factors meta‐analysis (1989–2013); Do they differ in Egypt?

Viral Hepatitis Infections in Southern Taiwan: A Multicenter Community‐based Study

Viral Etiology of Hepatocellular Carcinoma and HCV Genotypes in Taiwan

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