Risk Factors Associated With COVID-19 Related Anosmia And Ageusia

Sehanobish, Esha; Barbi, Mali; Fong, Valerie; Kravitz, Meryl; Matsumura, Cynthia; Tejera, Denise Sanchez; Asad, Mohammad; Ferastraoaru, Denisa; O’Neill, Meaghan; Karagic, Merhunisa; Akhbar, Nadeem; Bottalico, Danielle; Patel, Viraj V.; Hudes, Golda; Kim, Mimi; Eisenberg, Ruth; Nath, Avindra; Smith, Bryan; Ow, Thomas J.; Jerschow, Elina

doi:10.1016/j.jaci.2020.12.488

Cited by 2 publications

(1 citation statement)

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“…The clinical course of olfactory loss after SARS-CoV-2 infection is not entirely understood, and the evidence of the duration and recovery of this symptom is inconsistent across studies (Agyeman et al, 2020;Santos et al, 2021). Studies are being made to elucidate how the initial severity of the dysfunction, viral load, concomitant symptoms, medical history, age, and sex are associated with persistent olfactory dysfunction (Saussez et al, 2021;Sehanobish et al, 2021;Chapurin et al, 2022;Tan et al, 2022). However, these variables are not yet thoroughly studied, and the results are contradictory.…”

Section: Discussionmentioning

confidence: 99%

Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID

et al. 2023

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Background and purposeThe coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. The persistent symptoms of anosmia or hyposmia were associated in previous studies with the development of memory impairment and mood disturbances. We aimed to investigate the association between the chronicity of reported olfactory dysfunction and subjective and objective cognitive performance in long-COVID patients and to explore whether their emotional symptoms are related to their cognition.MethodsOne hundred twenty-eight long-COVID participants were recruited. Reported symptomatology, subjective memory complaints, anxiety and depression symptomatology, and trait-anxiety were assessed. Subjective memory complaints and mood disturbances were compared among groups of participants with olfactory dysfunction as an acute (AOD), persistent (POD), or nonexistent (NOD) symptom. Seventy-six of the volunteers also participated in a face-to-face session to assess their objective performance on tests of general cognitive function and verbal declarative memory. Objective cognitive performance and mood disturbances were compared among the AOD, POD, and NOD groups.ResultsThe subjective memory complaints and the anxiety and depression symptoms were similar among the groups, but the score in general cognitive function was lower in the participants with symptoms of acute olfactory dysfunction than in those with no olfactory symptoms at any time. Participants’ memory complaints were positively related to their emotional symptoms. The relationship between depressive symptomatology and memory complaints interacted with the olfactory dysfunction, as it only occurred in the participants without symptoms of olfactory dysfunction. Depressive symptomatology and acute olfactory symptoms were negatively associated with general cognitive function and delayed memory performance. The months elapsed from diagnosis to assessment also predicted delayed memory performance. Anxious symptomatology was negatively associated with the immediate ability to recall verbal information in participants who did not present olfactory dysfunction in the acute phase of the infection.ConclusionOlfactory dysfunction in the acute phase of the infection by COVID-19 is related to cognitive deficits in objective tests, and mood disturbances are associated with self-reported and objective memory. These findings may contribute to further understanding the neuropsychological and emotional aspects of long-COVID.

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Section: Discussionmentioning

confidence: 99%