Risk factors associated with alterations in carotid intima—media thickness in hypertension

Zanchetti, Alberto; Mg, Bond; Hennig, Michael; Neiss, A; Mancia, Giuseppe; C, Dal Palù; Hansson, Lennart; Magnani, B; Rühle, KH; Reid, John L.; Rodicio, José L.; Safar, Michel E.; Eckes, L; Ravinetto, Raffaella

doi:10.1097/00004872-199816070-00008

Cited by 268 publications

(152 citation statements)

References 34 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…2,5, 6 Bots et al 24 suggested that certain degrees of carotid intima-media thickening appear to reflect an adaptive response, whereas, beyond a certain limit, CCA-IMT increases more rapidly than lumen diameter, revealing atherosclerotic development. In the Rotterdam study, 25 this limit was considered to occur beyond an IMT of 1.00-1.10 mm.…”

Section: Methodological Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Association between pulse pressure, carotid intima–media thickness and carotid and/or iliofemoral plaque in hypertensive patients

Kesri

Safar

et al. 2004

J Hum Hypertens

View full text Add to dashboard Cite

Increased common carotid artery intima-media thickness (CCA-IMT) and carotid and/or iliofemoral (C/IF) plaque are frequent in subjects treated for hypertension, but their association with pulse pressure (PP) has rarely been studied. Using ultrasound techniques, CCA-IMT and C/IF plaques were studied in 323 hypertensive subjects, who were classified into four groups according to the adequacy of blood pressure (BP) control (systolic BP (SBP) o140 mmHg and diastolic BP (DBP) o90 mmHg) and PP (high or low). After adjustment for confounding variables, an increase in CCA-IMT was the only factor significantly and independently associated with high PP, irrespective of the effectiveness of blood pressure control and of antihypertensive drug treatment. CCA-IMT correlated with age, PP, waist-to-hip ratio, tobacco consumption, and heart rate. C/IF plaques correlated with age, tobacco consumption, diabetes mellitus, and dyslipidaemia. To conclude, even with SBPo140 mmHg and DBPo90 mmHg on treatment, hypertensive subjects may have increased CCA-IMT values and C/IF plaque. Four cardiovascular risk factors seem to be involved in these alterations, namely tobacco consumption, dyslipidaemia, diabetes and increased PP. Only the latter factor does not have a standardized effective treatment.

show abstract

Section: Methodological Considerationsmentioning

confidence: 99%

“…[1][2][3][4][5][6] In most recent prospective studies, CCA-IMT and/or aortic abdominal calcifications significantly predicted the occurrence of cardiovascular events. 7,8 PP, a significant independent marker of cardiovascular mortality, 9,10 has been found in many experimental and clinical studies to modulate IMT.…”

Section: Introductionmentioning

confidence: 99%

Association between pulse pressure, carotid intima–media thickness and carotid and/or iliofemoral plaque in hypertensive patients

Kesri

Safar

et al. 2004

J Hum Hypertens

View full text Add to dashboard Cite

show abstract

“…A lesion was considered a plaque in the presence of an average IMT Ն1.3 mm or a maximum IMT Ն1.5 mm. 16 …”

Section: Carotid Ultrasonographymentioning

confidence: 99%

Cardiovascular Status of Carriers of the Apolipoprotein A-I _Milano Mutant

et al. 2001

View full text Add to dashboard Cite

Background-Carriers of the apolipoprotein A-I Milano (apoA-I M ) mutant present with very low plasma HDL cholesterol and moderate hypertriglyceridemia, apparently not leading to premature coronary heart disease. The objective of this study was to establish whether this high-risk lipid/lipoprotein profile is associated with structural changes in the carotid arteries and heart, indicative of preclinical atherosclerosis. Methods and Results-Twenty-one A-I M carriers were compared with age-and sex-matched control subjects from the same kindred and with 2 series of matched subjects with primary hypoalphalipoproteinemia (HA). Structural changes in the carotid arteries were defined as the intima-media thickness (IMT) measured by B-mode ultrasound. HA subjects, both recruited among patients attending our Lipid Clinic and blood donors, showed significant thickening of the carotids (average IMT, 0.86Ϯ0.25 and 0.88Ϯ0.29 mm, respectively) compared with control subjects (average IMT, 0.64Ϯ0.12 mm); the apoA-I M carriers instead showed normal arterial thickness (average IMT, 0.63Ϯ0.10 mm). Moreover, a significantly higher prevalence of atherosclerotic plaques was found in patients and blood donors with HA (both 57%) compared with apoA-I M carriers (33%) and control subjects (21%). Echocardiographic findings and maximal treadmill ECG did not differ significantly between apoA-I M carriers and control subjects, apart from a slight increase in left ventricular end-diastolic dimension in the carriers. Conclusions-Despite severe HA, carriers of the apoA-I M mutant do not show structural changes in the arteries and heart, in contrast to HA subjects, who are characterized by a marked increase in carotid IMT and increased prevalence of atherosclerotic plaques.

show abstract

“…The IMT was calculated on two-dimensional longitudinal sections of the carotid artery as the distance from the leading edge of the first echogenic line to the leading edge of the second echogenic line according to the methods of Pignoli et al 20 and Salonen et al 21 A plaque was defined as presence of a focal thickening greater than 1.3 mm in any segment of either carotid artery. 22 IM thickening was diagnosed when common carotid IMT exceeded 0.8 mm. 23 As previously reported in our laboratory the intraobserver and the interobserver coefficients of variation for LV mass index are 7.4% and 8.6%, respectively, and for common carotid IMT 9.2% and 10.1%.…”

Section: Carotid Ultrasonographymentioning

confidence: 99%

Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension

et al. 2002

View full text Add to dashboard Cite

Left ventricular (LV) concentric remodelling is an adaptive change in cardiac geometry frequently observed in arterial hypertension. This study was addressed to investigate the extent of extracardiac target organ damage (TOD) in patients with LV concentric remodelling. Two groups of never-treated essential hypertensives, 31 with normal LV geometry (group I, relative wall thickness: 0.39) and 31 with LV concentric remodelling (group II, relative wall thickness: 0.47) matched for age, sex, body mass index and mean 24-h systolic blood pressure (BP), were included in the study. They underwent clinical and laboratory examination, 24-h ambulatory BP monitoring (ABPM), 24-h urinary collection for microalbuminuria, non-mydriatic photography of ocular fundi, echocardiography and carotid ultrasonography. In both groups age (I: 51 ؎ 11 years; II: 51 ؎ 11

show abstract

Risk factors associated with alterations in carotid intima—media thickness in hypertension

Cited by 268 publications

References 34 publications

Association between pulse pressure, carotid intima–media thickness and carotid and/or iliofemoral plaque in hypertensive patients

Association between pulse pressure, carotid intima–media thickness and carotid and/or iliofemoral plaque in hypertensive patients

Cardiovascular Status of Carriers of the Apolipoprotein A-I _Milano Mutant

Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension

Contact Info

Product

Resources

About

Risk factors associated with alterations in carotid intima—media thickness in hypertension

Cited by 268 publications

References 34 publications

Association between pulse pressure, carotid intima–media thickness and carotid and/or iliofemoral plaque in hypertensive patients

Association between pulse pressure, carotid intima–media thickness and carotid and/or iliofemoral plaque in hypertensive patients

Cardiovascular Status of Carriers of the Apolipoprotein A-I Milano Mutant

Left ventricular concentric remodelling and extracardiac target organ damage in essential hypertension

Contact Info

Product

Resources

About

Cardiovascular Status of Carriers of the Apolipoprotein A-I _Milano Mutant