Risk factors and state-of-the-art indications for boost irradiation in invasive breast carcinoma

Polo, Alfredo; Polgár, Csaba; Hannoun‐Lévi, Jean‐Michel; Guinot, J.L.; Gutiérrez, Cristina; Galalae, R.; Limbergen, Erik; Strnad, Vratislav

doi:10.1016/j.brachy.2017.03.003

Cited by 31 publications

(18 citation statements)

References 126 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As far as patient selection criteria for APBrI, we suggest using the criteria as published by Hannoun-Levi et al [2]. Furthermore we advise using criteria as analysed and described previously for patient selection for boost [34][35][36][37][38].…”

Section: General Issues Related To Multi-catheter Hdr-/pdr-brachytherapymentioning

confidence: 99%

“…A biologically equivalent total dose (EQD2 for a/b = 4-5 Gy) in the range of 10-20 Gy in 1 to 4 fractions should be selected according to current recommendations [37].…”

Section: The Recommended Schedules For Boost With Hdr-brachytherapymentioning

confidence: 99%

“…Pulsed-dose 0.5-0.8 Gy/pulse, total dose 10-20 Gy [37], scheduled every hour, 24 h per day, total treatment time 1-2 days.…”

Section: The Recommended Schedules For Boost With Pdr-brachytherapy Arementioning

confidence: 99%

See 2 more Smart Citations

ESTRO-ACROP guideline: Interstitial multi-catheter breast brachytherapy as Accelerated Partial Breast Irradiation alone or as boost – GEC-ESTRO Breast Cancer Working Group practical recommendations

Strnad

Major

Polgár

et al. 2018

Radiotherapy and Oncology

Self Cite

121

View full text Add to dashboard Cite

Recent standards and guidelines for the use of APBI with different multi-catheter image-guided brachytherapy techniques have been defined. Different techniques are used to insert the catheters. Guidelines are mandatory to assure precise catheter insertion for coverage of the target volume and to guarantee high-quality dosimetry. The same rules apply for brachytherapy based boost irradiation for breast cancer after whole breast irradiation as well as for partial breast re-irradiation.

show abstract

Section: General Issues Related To Multi-catheter Hdr-/pdr-brachytherapymentioning

confidence: 99%

“…A biologically equivalent total dose (EQD2 for a/b = 4-5 Gy) in the range of 10-20 Gy in 1 to 4 fractions should be selected according to current recommendations [37].…”

Section: The Recommended Schedules For Boost With Hdr-brachytherapymentioning

confidence: 99%

See 1 more Smart Citation

ESTRO-ACROP guideline: Interstitial multi-catheter breast brachytherapy as Accelerated Partial Breast Irradiation alone or as boost – GEC-ESTRO Breast Cancer Working Group practical recommendations

Strnad

Major

Polgár

et al. 2018

Radiotherapy and Oncology

Self Cite

121

View full text Add to dashboard Cite

show abstract

“…A recent consensus recommends a dose escalation above 16 Gy EQD2 in all cases of positive resection margins, and in cases aged ≤40 years with close margins . Doses as high as 26 Gy with low‐dose‐rate (LDR‐BT) boost after WBI have been used in cases with positive margins, but at 14 years have not improved the results and the severe fibrosis increased from 3% to 13%.…”

Section: Discussionmentioning

confidence: 99%

Can invasive breast carcinoma with close or positive margins be managed without a new surgery?

et al. 2018

View full text Add to dashboard Cite

We present the long-term outcome (FU 127 months) of a prospective study with 248 breast cancer patients with close or positive surgical margin, treated with 50 Gy whole breast irradiation plus high-dose-rate boost, 3 × 4.4 Gy. Actuarial breast failure at 10/15 years was 6.5%/11.6%; with positive margin (120) 6.8%/ 14.8%, with margin ≤2 mm (76) 9.8%/9.8%, with margin >2 mm <5 mm (52) 2%/ 2%. In 90 patients aged ≤50 was 11.9%/17.8%, between 51 and 70, 3.8%/8.2%, >70, 0%. Fibrosis appeared in 26.7%. Cosmetic outcome was excellent/good in 85.8%. This approach avoids a second surgery in women >50 with positive surgical margin, or with close margins in all ages. K E Y W O R D Sbrachytherapy, breast, invasive carcinoma, margins

show abstract

“…There is no evidence for difference between electron or photon or brachytherapy boost or intraoperative RT (IORT) techniques . The joint Groupe European de Curietherapie (GEC) and the European Society for Radiotherapy & Oncology (ESTRO) Breast Cancer Working Group recently provided clinical guidance for the use of boost RT after WBI (either standard or hypo‐fractioned) based on three stratified risk (low, intermediate, and high) groups …”

Section: Specific Rt Boost Effectsmentioning

confidence: 99%

Oncoplastic breast surgery and radiotherapy-Adverse aesthetic outcomes, proposed classification of aesthetic components, and causality attribution

Agrawal

2019

Breast J

View full text Add to dashboard Cite

The aim of this paper is to discuss and understand the interplay of surgical and radiotherapy (RT) techniques that potentially affect the aesthetic outcomes following breast conservation treatment. It reviews the reported cosmetic outcomes within the practice‐changing RT trials incorporating varied fractionation regimes as well as sequence (before, during, or after surgery) over the past two decades. The paper importantly highlights an overall improvement in breast surgical techniques particularly oncoplastic breast conservation techniques due to dedicated and streamlined training of late. Hence, erstwhile complications or sequel of breast surgery and associated post‐RT aesthetic concerns may not be of the same variety or magnitude that were noted in the past. Paper thus concludes by highlighting the paradigm shift in the breast surgical practice that will have a bearing on the accuracy of RT outcomes assessed (within or out with clinical trials) with implications as a potential research and outcomes assessment gap.

show abstract

Risk factors and state-of-the-art indications for boost irradiation in invasive breast carcinoma

Cited by 31 publications

References 126 publications

ESTRO-ACROP guideline: Interstitial multi-catheter breast brachytherapy as Accelerated Partial Breast Irradiation alone or as boost – GEC-ESTRO Breast Cancer Working Group practical recommendations

ESTRO-ACROP guideline: Interstitial multi-catheter breast brachytherapy as Accelerated Partial Breast Irradiation alone or as boost – GEC-ESTRO Breast Cancer Working Group practical recommendations

Can invasive breast carcinoma with close or positive margins be managed without a new surgery?

Oncoplastic breast surgery and radiotherapy-Adverse aesthetic outcomes, proposed classification of aesthetic components, and causality attribution

Contact Info

Product

Resources

About