Risk Factors and Prognostic Factors of Local Recurrence after Radiofrequency Ablation of Hepatocellular Carcinoma

Radiofrequency ablation of hepatocellular carcinoma: Long-term results and prognostic factors in 235 Western patients with cirrhosis

“…As previously reported, [3][4][5][6][7][8][9] we observed that liver function strongly influenced overall and HCC-free survival rates. Thus, prothrombin activity, albumin, total bilirubin, and Child-Pugh class were among the strongest predictors of outcome with the serum AFP level and multinodularity.…”

“…1,2 Long-term results of RFA in a large series of patients are often difficult to compare due to the heterogeneity of selection and patient management, in light of the institution's policy for approaches used (percutaneous or intraoperative) or the indication of additional treatments, especially transarterial chemoembolization (TACE). [3][4][5][6] However, there is currently a broad consensus regarding the major influence of the severity of the underlying liver disease in HCC patients. [3][4][5][6][7][8][9] This point may in part explain discrepancies in long-term survival rates reported between Western and Eastern series.…”

“…[3][4][5][6] However, there is currently a broad consensus regarding the major influence of the severity of the underlying liver disease in HCC patients. [3][4][5][6][7][8][9] This point may in part explain discrepancies in long-term survival rates reported between Western and Eastern series. European patients are usually older, with a higher rate of alcoholic cirrhosis and a more advanced cirrhosis, explaining the fact that only a small percentage of them (Ͻ10%) are candidates for resection.…”

“…As a matter of fact, iterative RFA sessions can be performed for limited recurrence more easily than resection. 4,25,26 The purpose of this retrospective study was to evaluate the long-term results of RFA alone as first-line treatment and to determine the prognostic factors in a well-defined and closely monitored cohort of 235 consecutive Western patients with cirrhosis and early-stage HCC defined as HCC Յ5 cm diameter and fewer than three tumors.…”

Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis

“…Because of this, there has been great interest in evaluating factors that influence prognosis in HCC. The most widely studied prognostic factors are related to pathological characteristics of the neoplasm, including tumour size, grade, stage, and vascular invasion (Tsai et al, 2000;Mann et al, 2007;Zhou et al, 2007;Lam et al, 2008). A variety of other potential serum prognostic markers, however, remain to be further characterised (Mann et al, 2007).…”