Risk Factors and Prognosis of Stroke in Gynecologic Cancer Patients

Abstract

Increased life expectancy and cancer prevalence rates expose patients to a higher risk of developing other comorbidities such as stroke. This study aimed to evaluate the risk factors for and prognosis of stroke in patients with gynecological cancers. A single-center retrospective cohort study was conducted on patients with cervical, endometrial, and epithelial ovarian cancers. Patients were classified into three groups based on the period of stroke onset: at least one year before cancer diagnosis, within one year before cancer diagnosis to six months after the last treatment date, and six months after the last treatment date. Among the 644 patients, stroke occurred in 54 (8.4%). In univariate analysis, stroke was significantly associated with overall survival. In contrast, in multivariate analysis, stroke was significantly associated with age and hypertension, but not with overall survival. Age, pulmonary thromboembolism/deep vein thrombosis, histological grade, and tumor stage were significantly associated with overall survival. Therefore, it is important to establish an appropriate examination and treatment plan for patients with gynecologic cancers using a multidisciplinary approach that incorporates the patient’s age, medical condition, and tumor characteristics rather than excessively considering the adverse effects of stroke on cancer prognosis.

Role of SLC7A11/xCT in Ovarian Cancer

“…Almost 50% of ovarian cancers occur in women aged >65 years and are the major cause of death since most diagnoses are often made when the disease is already at an advanced stage [ 1 ]. Although the most common risk factors for developing ovarian cancer are genetic and epigenetic factors, environmental factors and lifestyle also have important roles in its etiopathogenesis [ 2 , 3 ].…”