Risk factors and prognoses of invasive Candida infection in surgical critical ill patients with perforated peptic ulcer

Li, Yia-Ting; Wang, Yao-Chen; Yang, Shun-Fa; Law, Yat-Yin; Shiu, Bei-Hao; Chen, Te-An; Wu, Shih-Chi; Lu, Min-Chi

doi:10.1016/j.jmii.2022.03.001

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…The risk of disseminated candidiasis has increased due to the wide application of broad-spectrum antibiotics, glucocorticoids, and immunosuppressants, especially because of their increased use in AIDS and cancer patients. It was reported that C. albicans was the primary pathogen of invasive Candida infection (74.29%) in patients with perforated peptic ulcers who received laparotomies or laparoscopic surgery in Taiwan, China [3]. In addition, the mortality rate of sepsis (approximately 40%) caused by C. albicans is higher than that of any other sepsis caused by fungi or bacteria in the USA [4].…”

Section: Introductionmentioning

confidence: 99%

RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans

Ma,

Sui,

Wang

et al. 2023

Molecules

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Infections caused by Candida albicans (C. albicans) and increasing resistance to commonly used drugs lead to a variety of mucosal diseases and systemic infectious diseases. We previously confirmed that the essential oil of Clausena lansium (Lour.) Skeels seeds (CSEO) had antifungal activity against C. albicans, but the detailed mechanism between the chemical components and antifungal activity is unclear. In this study, a quantitative analysis of five volatile components of CSEO, including sabinene, α-phellandrene, β-phellandrene, 4-terpineol, and β-caryophyllene, was carried out using the gas chromatography–mass spectrometry (GC–MS) method. Both the broth dilution and kinetic growth methods proved that the antifungal activity of CSEO against fluconazole-resistant C. albicans was better than that of its main components (sabinene and 4-terpineol). To further investigate the inhibitory mechanism, the transcriptional responses of C. albicans to CSEO, sabinene, and 4-terpineol treatment were determined based on RNA-seq. The Venn diagram and clustering analysis pattern of differential expression genes showed the mechanism of CSEO and 4-terpineol’s anti-C. albicans activity might be similar from the perspective of the genes. Functional enrichment analysis suggested that CSEO regulated adherence-, hyphae-, and biofilm-formation-related genes, which may be CSEO’s active mechanism of inhibiting the growth of fluconazole-resistant C. albicans. Overall, we preliminarily revealed the molecular mechanism between the chemical components and the antifungal activity of CSEO against C. albicans. This study provides new insights to overcome the azole resistance of C. albicans and promote the development and application of C. lansium (Lour.) Skeels seeds.

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Section: Introductionmentioning

confidence: 99%

RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans

Ma,

Sui,

Wang

et al. 2023

Molecules

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“…Fungal infections can cause life-threatening complications. Among the various kinds of fungal infections, invasive candidiasis and candidemia were ranked among the top 10 nosocomial infections in the last decade ( 1 ) and are notable invasive fungal diseases (IFD) that frequently cause high mortality rates ranging from 30% to 50% ( 2 , 3 ). Similarly, invasive pulmonary aspergillosis (IPA) has been reported to result in morbidities; particularly, 27.4% to 90% of IPA cases result in fatality, depending on the IPA severity and immune condition of patients ( 4 – 6 ).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Susceptibilities of Worldwide Isolates of Intrapulmonary Aspergillus Species and Important Candida Species in Sterile Body Sites against Important Antifungals: Data from the Antimicrobial Testing Leadership and Surveillance Program, 2017–2020

et al. 2022

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In addition to monitoring the antifungal susceptibilities of clinically important fungi, reviewing the PK/PD indices and the clinical therapy experience of antifungals under evaluation are important to guide an appropriate antifungal prescription. The efficacies of liposomal amphotericin B complex and anidulafungin for the treatment of pulmonary aspergillosis caused by different Aspergillus species need to be periodically evaluated in the future.

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Predicting in-hospital mortality risk for perforated peptic ulcer surgery: the PPUMS scoring system and the benefit of laparoscopic surgery: a population-based study

Huang

et al. 2023

Surg Endosc

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Risk factors and prognoses of invasive Candida infection in surgical critical ill patients with perforated peptic ulcer

Cited by 3 publications

References 35 publications

RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans

RNA-Seq-Based Transcriptomics and GC–MS Quantitative Analysis Reveal Antifungal Mechanisms of Essential Oil of Clausena lansium (Lour.) Skeels Seeds against Candida albicans

In Vitro Susceptibilities of Worldwide Isolates of Intrapulmonary Aspergillus Species and Important Candida Species in Sterile Body Sites against Important Antifungals: Data from the Antimicrobial Testing Leadership and Surveillance Program, 2017–2020

Predicting in-hospital mortality risk for perforated peptic ulcer surgery: the PPUMS scoring system and the benefit of laparoscopic surgery: a population-based study

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