Risk factors and outcomes associated with recurrent autoimmune hepatitis following liver transplantation

Montano‐Loza, Aldo J.; Ronca, Vincenzo; Ebadi, Maryam; Hansen, Bettina E.; Hirschfield, Gideon M.; Elwir, Saleh; Alsaed, Mohamad; Milkiewicz, Piotr; Janik, Maciej K.; Marschall, Hanns‐Ulrich; Burza, Maria Antonella; Efe, Cumali; Çalışkan, Ali Rıza; Harputluoğlu, Murat; Kabaçam, Gökhan; Onófrio, Fernanda de Quadros; Selzner, Nazia; Bonder, Alan; Pares, A.; Llovet, Laura Patricia; Akyıldız, Murat; Arıkan, Çiğdem; Manns, Michael P.; Taubert, Richard; Weber, Anna-Lena; Schiano, Thomas D.; Haydel, Brandy; Czubkowski, Piotr; Socha, Piotr; Ołdak, Natalia; Akamatsu, Nobuhisa; Tanaka, Atsushi; Levy, Cynthia; Martin, Éric; Goel, Aparna; Sedki, Mai; Jankowska, Irena; Ikegami, Toru; Rodríguez, María José Blanco; Sterneck, Martina; Weiler‐Normann, Christina; Schramm, Christoph; Donato, Maria Francesca; Lohse, Ansgar W.; Andrade, Raúl J.; Patwardhan, Vilas; Hoek, Bart van; Biewenga, Maaike; Kremer, Andreas E.; Ueda, Yoshihide; Deneau, Mark; Pedersen, Mark; Mayo, Marlyn J.; Floreani, Annarosa; Burra, Patrizia; Secchi, Maria Francesca; Beretta‐Piccoli, Benedetta Terziroli; Sciveres, Marco; Maggiore, Giuseppe; Jafri, Syed-Mohammed; Debray, Dominique; Girard, M; Lacaille, Florence; Lytvyak, Ellina; Mason, Andrew L.; Heneghan, Michael A.; Oo, Ye Htun

doi:10.1016/j.jhep.2022.01.022

Cited by 22 publications

(26 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is mainly caused by injury mediated by the immune system and, in the absence of quick and effective treatment, it increases the risk for developing end-stage liver disease. 52 The morphological features of autoimmune hepatitis are often variable, but the latter is known for its interface hepatitis on pathological sections as well as the absence of changes typical of other types of liver disease, such as hypergammaglobulinemia, which is more common in women. 53 However, the pathogenesis of autoimmune hepatitis, especially the specific processes involved in the death of hepatocytes, are yet to be uncovered.…”

Section: Ferroptosis In Autoimmune Hepatitismentioning

confidence: 99%

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Zhu¹,

Luo²,

Zhu³

et al. 2023

JIR

View full text Add to dashboard Cite

Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy.

show abstract

Section: Ferroptosis In Autoimmune Hepatitismentioning

confidence: 99%

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Zhu¹,

Luo²,

Zhu³

et al. 2023

JIR

View full text Add to dashboard Cite

show abstract

“…Four of the 38 patients had histopathological features compatible with recurrent AIH. AIH recurrence posttransplant is well-de ined, with a prevalence of 17% -42% [31]. It is a major cause of graft dysfunction and reduced graft survival requiring re-transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…Of late, our clinical practice has changed with the increasing use of AZA instead of MMF. This is due to a recent study which showed an increased risk of recurrence with the use of MMF [31]. However, given the established difference of pharmacodynamics among the black population, a concern remains if a signi icant inding in a majority Caucasian population would have the same effect on a pre-dominantly black population.…”

Section: Discussionmentioning

confidence: 99%

Outcome of liver transplantation for autoimmune hepatitis in South Africa

Siddiqui¹,

Kapila²,

Bilal³

et al. 2022

Ann Clin Gastroenterol Hepatol

View full text Add to dashboard Cite

Background: Liver Transplantation (LT) is the definitive treatment for Autoimmune Hepatitis (AIH) in patients with decompensated cirrhosis, liver failure and hepatocellular carcinoma. Outcomes of LT in AIH among black-Africans are not well-defined. We performed a single-center retrospective-review of adult LT patients. The study period was from 1st August 2004-31st August 2019. The primary aim was to document 1- & 5- year patient and graft survival. A secondary aim was to compare the survival of black-Africans to Caucasians. Data was analyzed using survival-analysis. Results: A total of 56 LT were performed for AIH. Sixty-seven percent (n = 38/56) had confirmed AIH on explant histology. Of these, the majority i.e., 79% (30/38) were female and 21% (8/38) were male. There were equal numbers of black-African 42% (n = 16/38) and Caucasian 42% (n = 16/38) patients. Rejection was four-times higher in black-Africans as compared to Caucasians. Forty-four percent (n = 17/38) had an acute rejection episode and 13% (5/38) had chronic rejection. Recurrence was found in four black-African females. Post-LT patient survival at 1- and 5- years was 86.5% and 80.7%, and graft survival was 94% and 70.8% respectively. The 5- year patient survival was insignificantly lower for black-Africans (73.9%) as compared to Caucasians (83.7%) (p - value 0.26, CI 6.3 - 12.2). Five-year graft survival was significantly lower among black-Africans (55%) as compared to Caucasians (84.8%) (p - value 0.003 CI 3.8 - 8.1) Conclusion: Black-Africans had a four-fold higher rate of rejection compared to Caucasians. Recurrent AIH was only found in patients of black ethnicity. Similar 1- & 5- year patient survival rates were observed between the two ethnicities. The 5-year graft survival among black-Africans was significantly lower than Caucasians.

show abstract

“…The recurrence of AIH is affected by antirejection medication type; thus, patients are recommended to be maintained with a steroidbased regimen at a higher dose than for patients without AIH. 34 Reported graft and patient survival rates are comparable to those of the non-AIH pediatric population. The recurrence rate is variable, as well as the time from LT, with a mean recurrence at 5 years follow-up, although this may also occur as early as 1 month after LT. 35…”

Section: Autoimmune Hepatitismentioning

confidence: 91%

Pediatric Liver Transplantation: Long-Term Follow-Up Issues

Bellini¹,

Lauro²,

D’Andrea³

et al. 2022

Exp Clin Transplant

View full text Add to dashboard Cite

Pediatric liver transplant is an established life-saving procedure for children with end-stage liver diseases, achieving excellent graft and patient survival but with effects on quality of life and psychological welfare in the long-term. With the natural increase in the number of pediatric transplant patients becoming adults, it is essential to successfully plan and manage issues affecting late outcomes in the vulnerable pediatric transplant population. This study offers an overview of the long-term surgical complications, the consequences of immunosuppression (such as posttransplant diabetes, hypertension, cardiovascular disease, and renal dysfunction), and the infection and malignancy risks. Finally, because quality of life is now an inclusive measurement of patient satisfaction, guidance on how to facilitate the transition to adulthood, empowering transplant recipients, is also provided.

show abstract

Risk factors and outcomes associated with recurrent autoimmune hepatitis following liver transplantation

Cited by 22 publications

References 40 publications

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge

Outcome of liver transplantation for autoimmune hepatitis in South Africa

Pediatric Liver Transplantation: Long-Term Follow-Up Issues

Contact Info

Product

Resources

About