Risk factors and impact on bone mineral density in postmenopausal Mexican mestizo women

Rojano-Mejía, David; Aguilar-Madrid, Guadalupe; López-Medina, Guillermo; Cortes-Espinosa, Leticia; Hernández-chiu, Maria C.; Canto-Cetina, Thelma; Vergara-López, Alma; Coral‐Vázquez, Ramón Mauricio; Canto, Patricia

doi:10.1097/gme.0b013e3181f2d3fb

Cited by 26 publications

(23 citation statements)

References 34 publications

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“…There are, of course, a few contrary studies that suggest lactation predicts lower BMD (261,336,352,472,559,686,770,946,971,973) or increases the risk of fracture (97,525,559,699). Smoking may cause breastfeeding to have a negative effect on BMD that is not seen in nonsmokers who breastfed (448).…”

Section: Human Datamentioning

confidence: 99%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

338

524

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During pregnancy and lactation, female physiology adapts to meet the added nutritional demands of fetuses and neonates. An average full-term fetus contains ϳ30 g calcium, 20 g phosphorus, and 0.8 g magnesium. About 80% of mineral is accreted during the third trimester; calcium transfers at 300-350 mg/day during the final 6 wk. The neonate requires 200 mg calcium daily from milk during the first 6 mo, and 120 mg calcium from milk during the second 6 mo (additional calcium comes from solid foods). Calcium transfers can be more than double and triple these values, respectively, in women who nurse twins and triplets. About 25% of dietary calcium is normally absorbed in healthy adults. Average maternal calcium intakes in American and Canadian women are insufficient to meet the fetal and neonatal calcium requirements if normal efficiency of intestinal calcium absorption is relied upon. However, several adaptations are invoked to meet the fetal and neonatal demands for mineral without requiring increased intakes by the mother. During pregnancy the efficiency of intestinal calcium absorption doubles, whereas during lactation the maternal skeleton is resorbed to provide calcium for milk. This review addresses our current knowledge regarding maternal adaptations in mineral and skeletal homeostasis that occur during pregnancy, lactation, and post-weaning recovery. Also considered are the impacts that these adaptations have on biochemical and hormonal parameters of mineral homeostasis, the consequences for long-term skeletal health, and the presentation and management of disorders of mineral and bone metabolism.

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Section: Human Datamentioning

confidence: 99%

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Kovacs

2016

Physiological Reviews

338

524

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“…Furthermore, these differences remained even after adjustment for covariates Values are mean and standard deviation (SD) for bone mineral densities (g/cm 2 ). P values <0.05 were considered statistically significant LS lumbar spine, TH total hip, FN femoral neck AGE (2013) 35:471-478shown in our population: BMI, years since menopause, and total duration of breastfeeding (Rojano-Mejía et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Exclusion criteria, as well as the risk factors for osteoporosis, were described previously (Rojano-Mejía et al 2011). Body height and weight were measured at baseline examination with the subject in a standing position with heavy outer clothes and without shoes.…”

Section: Subjectsmentioning

confidence: 99%

JAG1 and COL1A1 polymorphisms and haplotypes in relation to bone mineral density variations in postmenopausal Mexican-Mestizo Women

Rojano-Mejía

Coral‐Vázquez

Espinosa

et al. 2011

AGE

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Osteoporosis is characterized by low bone mineral density (BMD). One of the most important factors that influence BMD is the genetic contribution. The collagen type 1 alpha 1 (COL1A1) and the JAGGED (JAG1) have been investigated in relation to BMD. The aim of this study was to investigate the possible association between two single-nucleotide polymorphisms (SNPs) of COL1A1, their haplotypes, and one SNP of JAG1 with BMD in postmenopausal Mexican-Mestizo women. Seven hundred and fifty unrelated postmenopausal women were included. Risk factors were recorded and BMD was measured in lumbar spine, total hip, and femoral neck by dual-energy X-ray absorptiometry. DNA was obtained from blood leukocytes. Two SNPs in COL1A1 (rs1800012 and rs1107946) and one in JAG1 (rs2273061) were studied. Real-time PCR allelic discrimination was used for genotyping. The differences between the means of the BMDs according to genotype were analyzed with covariance. Deviations from Hardy-Weinberg equilibrium were AGE (2013) , and haplotype analysis of COL1A1 was conducted. Under a dominant model, the rs1800012 polymorphism of the COL1A1 showed an association with BMD of the lumbar spine (P00.021). In addition, analysis of the haplotype of COL1A1 showed that the G-G haplotype presented a higher BMD in lumbar spine. We did not find an association between the s1107946 and rs2273061 polymorphisms of the COL1A1 and JAG1, respectively. Our results suggest that the rs1800012 polymorphism of the COL1A1, in addition to one haplotype, were significantly associated with BMD variation in Mexican-Mestizo postmenopausal women.

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“…Dentre os artigos revisados, 33 apresentam delineamento seccional 12,13,[16][17][18][19][26][27][28][29][30][31][32][33][34][35][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] e um foi estudo de coorte. 56 A origem dos estudos se distribuiu entre: Estados Unidos da América -EUA (n=8), Turquia (n=7), China (n=3), Dinamarca (n=2), Japão (n=2), Itália (n=1), Holanda (n=1), Suécia (n=1), Grécia (n=1), Sri Lanka (n=1), Irã (n=1), Reino Unido (n=1), Caribe (n=1), México (n=1), Israel (n=1) e Coréia (n=1).…”

Section: Resultsunclassified

“…2 Estima-se que 40% das mulheres na pós-menopausa terão ao menos uma fratura por osteoporose. [6][7][8][9][10] Além da idade e de características de vida reprodutiva, [11][12][13][14][15][16][17][18][19] existem dois momentos fisiológicos durante os quais alterações hormonais influenciam o metabolismo ósseo e podem gerar aumento da perda de massa óssea em mulheres: amamentação e menopausa. 20 Durante a amamentação, ocorre intensa desmineralização da massa óssea materna, devido ao requerimento de cálcio aumentado para a produção de leite.…”

Section: Introductionunclassified

O efeito da amamentação na massa óssea de mulheres na pós-menopausa: revisão sistemática de estudos observacionais

Gonçalves

Ferreira

Hasselmann

et al. 2015

Rev. Bras. Saude Mater. Infant.

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Risk factors and impact on bone mineral density in postmenopausal Mexican mestizo women

Cited by 26 publications

References 34 publications

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

Maternal Mineral and Bone Metabolism During Pregnancy, Lactation, and Post-Weaning Recovery

JAG1 and COL1A1 polymorphisms and haplotypes in relation to bone mineral density variations in postmenopausal Mexican-Mestizo Women

O efeito da amamentação na massa óssea de mulheres na pós-menopausa: revisão sistemática de estudos observacionais

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