Risk Factors and Immediate Outcome of Early Onset Neonatal Sepsis

Bharad, Dr Rahul V

doi:10.18535/jmscr/v5i4.207

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…This study was also supported by a study conducted in Iraq which reported that neonates with neonatal sepsis who were born from mothers having history of fever were more likely to die than neonates with neonatal sepsis who were born from mothers who had no history of fever (24). Our study was also in line with a study conducted in India which reported that intra partum fever was signi cant predictor of mortality related to neonatal sepsis (25). This might be because the fact that the diseasecausing agent of maternal infection can ascend to the baby via circulation and during passage through the birth canal.…”

Section: Discussionsupporting

confidence: 91%

Time to Death and Its Predictors Among Neonates Admitted With Neonatal Sepsis at Public Referral Hospitals of Bahir Dar City, Northwest Ethiopia, 2021: Retrospective Cohort Study

Abebia

Kibret

Belete

et al. 2021

Preprint

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Background: In spite of recent advances in health care, neonatal sepsis is still one of the major causes of morbidity and mortality in neonates and is an ongoing major global public health challenge. Its incidence of mortality varies from health institution to health institution and within the same health institution at varied times and depends on predisposing factors. So the aim of this study was to determine the time to death and its predictors among neonates admitted with neonatal sepsis. Methods: An institutional based retrospective cohort study was conducted among 500 randomly selected neonatal charts. The data was entered using Epi data version 3.1, and exported to and analyzed at STATA version 14. Bivariable and multivariable cox regression analysis were conducted to identify predictors of mortality. Association was summarized using adjusted hazard ratio (AHR) and statistical significances were declared at 95% CI and P-value <0.05. Proportionality assumption was tested by global test based on Schoenfeld residuals analysis. Results: During the follow up time, 58 (11.6%) neonates were died with neonatal sepsis while the rest were censored. In this study the overall death incidence rate was 20.5 per 1000 neonate days. Comorbidity (AHR: 1.81, 95%, CI: 1.04, 3.17), late initiation of exclusive breast feeding over one hour (AHR: 2.29, 95%CI: 1.13,4.63), history of intra-partum fever(AHR: 7.37 95%CI: 2.28,23.79), Birth weight (AHR: 3.37, 95%CI: 1.54, 7.34) and place of delivery(AHR: 3.83, 95%, CI: 1.24, 11.83) were found potential independent predictors of mortality among neonates with neonatal sepsis.Conclusion: In this study, high death incidence rate was observed. The mean time to death among neonates was 4.41 days. With regard to predictors: birth weight, comorbidity, late initiation of exclusive breast feeding over one hour, history of intra partum fever and place of delivery were significant predictors of mortality among neonates admitted with neonatal sepsis.

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Section: Discussionsupporting

confidence: 91%

Time to Death and Its Predictors Among Neonates Admitted With Neonatal Sepsis at Public Referral Hospitals of Bahir Dar City, Northwest Ethiopia, 2021: Retrospective Cohort Study

Abebia

Kibret

Belete

et al. 2021

Preprint

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“…Similar observations were recorded by Jajoo M et al, Bhutta et al, Jumah et al and many others. [7][8][9][10]12,13 Similarly, associate higher mortality rates in patients with thrombocytopenia, CRP positivity, leucopoenia and hyperglycaemia. Although non-specific for neonatal sepsis, CRP has the highest sensitivity, specificity and high negative and high positive predictive values.…”

Section: Discussionmentioning

confidence: 99%

Predictors of mortality in neonatal septicemia in a tertiary care centre

Gosai

Shah

Samanth

2020

Int J Contemp Pediatr

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Background: Neonatal septicemia continues to be a major cause of mortality and morbidity in new-borns all over the world. Aim and objectives of the study were determining the risk factors for mortality in neonatal septicemia.Methods: A retrospective observational study of the demographics, clinical features and laboratory parameters of 100 neonates admitted in NICU of a tertiary care hospital from September 2019 to March 2020.Results: 67% of neonates delivered outside centre and 33% of neonates delivered at centre were found to have sepsis exclusively based on culture positivity. A significant association was found between very low birth rate (VLBW) (p value<0.001), prematurity (p value<0.01) and high neonatal mortality. Among the different clinical presentations of neonatal sepsis, lethargy (p value<0.02), apnea (p value<0.01) and hypothermia (p value<0.02) were found to be frequently associated with neonatal mortality. Further, C-reactive protein (CRP) positivity (p value<0.003), hyperglycaemia (p value<0.0009) and thrombocytopenia (p value<0.0009) were also associated with high neonatal mortality. Gram positive bacteria were frequently isolated from blood cultures of deceased neonates, Coagulase negative staphylococci (CoNS) (36.1%), being the commonest bacteria followed by B. subtilis (11.1%), Klebsiella spp. (11.1%) and Acinetobacter spp. (8.3%).Conclusion: Demographic factors like VLBW, prematurity, outborn deliveries, clinical and laboratory parameters like lethargy, apnea, hypothermia, thrombocytopenia and hyperglycemia are strong predictors of mortality in neonatal.

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“…n= (Z1-α/2) 2 × P (1-P) / d 2 Margin of error= 5% Z1-α/2 = Confidence level 95%=1.96 P = Expected proportion in population = 11.7% least among all [Rahul V Bharad et al] 6 d= absolute precision = 5% Informed and written consent was taken from the parents or guardian of the neonates. All neonates of both gender who were more than 30 weeks of gestation presenting to neonatal unit within 7 days of life fulfilling the definition of early onset sepsis as per operational definition were included and Patients who had received antibiotics before presentation and Patients not agreed to participate in study were excluded.…”

Section: Methodsmentioning

confidence: 99%

“…Prematurity was found in 71 (59.1%) patients and APGAR score <5 at 1 minute was found in 62 (51.7%) patients. [6,19] The purpose of this study is to find the maternal and neonatal contributing factors which are associated with increased risk of early onset of sepsis in neonates presenting to remotely situated tertiary care hospital in rural areas. Identification of risk factors will help us to predict the risk of early onset sepsis in neonates and will help us to start empiric treatment early and will decrease the mortality as well morbidity that is associated with neonatal sepsis.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors Associated with Early Onset of Sepsis

Shahzad¹,

Shahzad²,

Qadir³

et al. 2023

PJMHS

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Background: Neonatal sepsis (EOS) is among one of the leading cause of death that usually occurs due to infection in the first month of life and can be the result of various maternal and neonatal contributing factors. Objectives: To determine maternal and neonatal contributing factors for early onset of sepsis in neonates. Study design: cross sectional study Period: From 13th April 2019 to 12th Oct 2019. Settings: Neonatal units of pediatric medicine of central park teaching hospital Lahore and Bhatti international hospital Kasur. Material and methods: After approval from hospital ethical committee total 151 neonates were selected using non-probable consecutive sampling. Neonates of both gender who were having gestational age >30 weeks with early onset sepsis were enrolled. Patients who had received antibiotics before presentation were excluded. 5ml of venous blood after proper sterilization was taken from all patients and sent to hospital laboratory for WBC count, CRP and blood culture. Data was entered in pre-designed Performa and analyzed using SPSS 20. Results: There were total 151 patients in study, minimum and maximum age was 1 day and 7 days respectively with mean age of 3.66±1.88 days. Mean gestational age was 35.5±2.6 weeks and mean birth weight was 2.2±1.4 kg. There was slight increase in female patients 51% and 49% males. Among maternal contributing factors maternal fever was found in 64.9%, premature rupture of membrane was found in 43%, foul smelling liquor in 37.1% and meconium-stained amniotic fluid was found in 33.1% neonates. Among neonatal contributing factors prematurity was found in 66.2% low birth weight was present in 64.2%, and low APGAR score was present in 56.6 % neonates. Data was stratified for gender and contributing risk factors but p value was not statistically significant. Data was stratified for gestational age and p value was significant for prematurity, low birth weight and offensive smelling liquor. Conclusion: Prematurity, low birth weight, low APGAR score and maternal fever were significant contributing factors in EOS. Keywords: EOS, Neonatal contributing factors, Maternal contributing factors

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Risk Factors and Immediate Outcome of Early Onset Neonatal Sepsis

Abstract: Background -Neonatal septicemia remains one of the main causes of mortality and morbidity despite the progress in hygiene, introduction of new and potent antimicrobial agents for treatment

Cited by 6 publications

References 10 publications

Time to Death and Its Predictors Among Neonates Admitted With Neonatal Sepsis at Public Referral Hospitals of Bahir Dar City, Northwest Ethiopia, 2021: Retrospective Cohort Study

Time to Death and Its Predictors Among Neonates Admitted With Neonatal Sepsis at Public Referral Hospitals of Bahir Dar City, Northwest Ethiopia, 2021: Retrospective Cohort Study

Predictors of mortality in neonatal septicemia in a tertiary care centre

Risk Factors Associated with Early Onset of Sepsis

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