Risk factors and HIV infection among patients diagnosed with deep vein thrombosis at a regional/tertiary hospital in Kimberley, South Africa

Mampuya, FK; Steinberg, Wilhelm Johannes; Raubenheimer, Jacques

doi:10.1080/20786190.2018.1432135

Cited by 4 publications

(2 citation statements)

References 24 publications

(33 reference statements)

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“…[8,33] The majority of patients with VTE (59%) in our study were HIVpositive, as reported in other studies in SA. [2,34] However, HIV prevalence in the present study was markedly higher than the general HIV prevalence (12.7%) in SA. [4] Similarly, the prevalence of TB in our study population was higher (39%) than the prevalence reported in adults admitted over the study period (18.2%), and most TB patients were HIV co-infected.…”

Section: Fig 2 Patients Grouped According To the Duration Of Tb Treatment Prior To Onset Of Vte (N=38) (Art = Antiretroviral Therapy; Vtecontrasting

confidence: 60%

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Venous thromboembolic disease in adults admitted to hospital in a setting with a high burden of HIV and TB

Moodley

Martinson

Joyimbana

et al. 2021

Afr J Thorac Crit Care Med

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Background. HIV and tuberculosis (TB) independently cause an increased risk for venous thromboembolic disease (VTE): deep vein thrombosis (DVT) and/or pulmonary embolism (PE). Data from high HIV and TB burden settings describing VTE are scarce. The Wells' DVT and PE scores are widely used but their utility in these settings has not been reported on extensively. Objectives. To evaluate new onset VTE, compare clinical characteristics by HIV status, and the presence or absence of TB disease in our setting. We also calculate the Wells' score for all patients. Methods. A prospective cohort of adult in-patients with radiologically confirmed VTE were recruited into the study between September 2015 and May 2016. Demographics, presence of TB, HIV status, duration of treatment, CD4 count, viral load, VTE risk factors, and parameters to calculate the Wells' score were collected. Results. We recruited 100 patients. Most of the patients were HIV-infected (n=59), 39 had TB disease and 32 were HIV/TB co-infected. Most of the patients had DVT only (n=83); 11 had PE, and 6 had both DVT and PE. More than a third of patients on antiretroviral treatment (ART) (43%; n=18/42) were on treatment for <6 months. Half of the patients (51%; n=20/39) were on TB treatment for <1 month. The median (interquartile range (IQR)) DVT and PE Wells' score in all sub-groups was 3.0 (1.0 -4.0) and 3.0 (2.5 -4.5), respectively. Conclusion. HIV/TB co-infection appears to confer a risk for VTE, especially early after initiation of ART and/or TB treatment, and therefore requires careful monitoring for VTE and early initiation of thrombo-prophylaxis.

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Section: Fig 2 Patients Grouped According To the Duration Of Tb Treatment Prior To Onset Of Vte (N=38) (Art = Antiretroviral Therapy; Vtecontrasting

confidence: 60%

“… [5] This differs from another SA study that reported malignancy to be high in HIV-negative patients. [34] Kaposi’s sarcoma is related to VTE development owing to vessel compression and infiltration. [38] The Wells’ scores for those with a DVT was the same in all the HIV and/or TB sub-groups.…”

Section: Discussionmentioning

confidence: 99%

Venous thromboembolic disease in adults admitted to hospital in a setting with a high burden of HIV and TB

Moodley

Martinson

Joyimbana

et al. 2021

Afr J Thorac Crit Care Med

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The value of electrocardiography in predicting inpatient mortality in patients with acute pulmonary embolism: A cross sectional analysis

Raghubeer,

Lahri,

Hendrikse

2024

African Journal of Emergency Medicine

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Long-Term Follow-up of Human Immunodeficiency Virus-Associated Pulmonary Hypertension: Clinical Features and Survival Outcomes of the Pan Africa Pulmonary Hypertension Cohort (PAPUCO)

Thienemann

Katoto

Azibani

et al. 2022

Open Forum Infectious Diseases

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Aims Data characterizing risk factors and long-term outcome studies on HIV-associated pulmonary hypertension (PH) in Africa are lacking. Methods The Pan African Pulmonary Hypertension Cohort, a multinational registry of 254 consecutive patients diagnosed with PH (97% of African descent) from nine centres in four African countries was implemented. We compared baseline characteristics and three-year survival of an HIV-infected cohort newly diagnosed with PH (PH/HIV+) to an HIV-uninfected cohort with PH (PH/HIV-). Results 134 participants with PH completed follow-up (47 PH/HIV + and 87 PH/HIV-; age/median 36 vs 44 years; p = 0.0004). Cardiovascular risk factors and co-morbidities were similar except for previous tuberculosis (62% vs 18%, p < 0.0001). Six-minute walk distance (6MWD) < 300 meters was common in PH/HIV- (p = 0.0030), but PH/HIV + had higher heart (p = 0.0160) and respiratory (p = 0.0374) rates. Thirty-six percent of PH/HIV + and 15% of PH/HIV- presented with pulmonary arterial hypertension (PAH) (p = 0.0084), whereas 36% of PH/HIV + and 72% of PH/HIV- exhibited PH due to left heart disease (PHLHD) (p = 0.0009). PH due to lung diseases and hypoxia (PHLD) was frequent in PH/HIV + (36% vs 15%) but did not reach statistical significance. HIV-associated PAH tended to have a poorer survival rate compared to PHLHD/PHLD in HIV-infected patients. Conclusion PH/HIV + patients were younger and commonly had previous tuberculosis compared to PH/HIV- patients. Despite a better 6MWD at presentation, they had more signs and symptoms of early onset heart failure and a worse survival rate. Early echocardiography assessment should be performed in HIV-infected patients with history of tuberculosis who present with signs and symptoms of heart failure or post-tuberculosis lung disease.

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Risk factors and HIV infection among patients diagnosed with deep vein thrombosis at a regional/tertiary hospital in Kimberley, South Africa

Cited by 4 publications

References 24 publications

Venous thromboembolic disease in adults admitted to hospital in a setting with a high burden of HIV and TB

Venous thromboembolic disease in adults admitted to hospital in a setting with a high burden of HIV and TB

The value of electrocardiography in predicting inpatient mortality in patients with acute pulmonary embolism: A cross sectional analysis

Long-Term Follow-up of Human Immunodeficiency Virus-Associated Pulmonary Hypertension: Clinical Features and Survival Outcomes of the Pan Africa Pulmonary Hypertension Cohort (PAPUCO)

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