Risk factors and fraction of exhaled nitric oxide in obstructive sleep apnea in adults

Feng, Xiaokai; Guo, Xiaojuan; Lin, Junling; Zhao, Zhiling; Tong, Zhaohui

doi:10.1177/0300060520926010

Cited by 2 publications

(1 citation statement)

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“…Indeed, upper airway tissue biopsies from patients with OSA showed subepithelial oedema and increased inflammatory cell infiltration [ 28 , 37 , 38 , 39 ]. In addition, some studies have also reported increased levels of exhaled nitric oxide in patients with OSA [ 40 , 41 , 42 , 43 ]. However, a recent meta-analysis showed no significant differences in exhaled nitric oxide relative to control groups [ 44 ].…”

Section: Osa and Inflammationmentioning

confidence: 99%

Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases

Alterki

Abu‐Farha

Alshawaf

et al. 2023

IJMS

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Obstructive sleep apnoea (OSA) is a prevalent underdiagnosed disorder whose incidence increases with age and weight. Uniquely characterised by frequent breathing interruptions during sleep—known as intermittent hypoxia (IH)—OSA disrupts the circadian rhythm. Patients with OSA have repeated episodes of hypoxia and reoxygenation, leading to systemic consequences. OSA consequences range from apparent symptoms like excessive daytime sleepiness, neurocognitive deterioration and decreased quality of life to pathological complications characterised by elevated biomarkers linked to endocrine-metabolic and cardiovascular changes. OSA is a well-recognized risk factor for cardiovascular and cerebrovascular diseases. Furthermore, OSA is linked to other conditions that worsen cardiovascular outcomes, such as obesity. The relationship between OSA and obesity is complex and reciprocal, involving interaction between biological and lifestyle factors. The pathogenesis of both OSA and obesity involve oxidative stress, inflammation and metabolic dysregulation. The current medical practice uses continuous positive airway pressure (CPAP) as the gold standard tool to manage OSA. It has been shown to improve symptoms and cardiac function, reduce cardiovascular risk and normalise biomarkers. Nonetheless, a full understanding of the factors involved in the deleterious effects of OSA and the best methods to eliminate their occurrence are still poorly understood. In this review, we present the factors and evidence linking OSA to increased risk of cardiovascular conditions.

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