Risk factors and distribution of MDROs among patients with healthcare associated burn wound infection

Abstract

Introduction Patients with burn wounds are more susceptible to develop healthcare associated (HA) infection. Bacterial isolates from HA burn wound infection vary from one place to the other and also differ in terms of antimicrobial susceptibility pattern. The aim of our study was to assess the incidence of HA burn wound infection, risk factors and to determine the microbiological profile and antimicrobial susceptibility pattern of isolated pathogens. Methods This was a one-year retrospective descriptive study conducted between January 2017 and December 2017, in Al-Babtain Burn and Plastic Surgery center, Kuwait. The identification of bacterial isolates was conducted by conventional biochemical methods according to standard microbiological techniques and commercially available kits using analytical profile index procedure. Results Total body surface area >35% affected and length of stay more than 14 days were statistically significant risk factors for HA burn infection (RR of 10.057 and 5.912, respectively). Analysis of microbiological profile of these positive cultures indicated that the most common isolated organism was Acinetobacter baumannii followed by Klebsiella pneumoniae. Multidrug resistant organisms composed 65.85% of the positive isolates. Vancomycin, tigecycline, teicoplanin and linezolid showed 100% effectiveness for all Gram positive isolates. For Gram negative organisms, imipenem and meropenem showed 38.71% and 41.93% efficacy, respectively. Conclusion Identification of antimicrobial susceptibility patterns helps to tailor the required antibiotic policy to minimize the acquired infections among these vulnerable patients.

Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards

“…The equipment surfaces, the air, the room walls, and the medical waste in BICU may colonize higher levels of pathogens than those in BCW ( Palmieri, 2019 ; Montazeri et al., 2020 ). Last, healthcare procedures are perceived as one important route of transmission ( AL et al., 2018 ). Burn patients in BICU may receive multiple invasive procedures, such as central vein/urinary tract catheter, tracheotomy, fiberoptic bronchoscopy, mechanical ventilation, and so on ( Tejiram et al., 2019 ).…”

Bacterial Profile, Antimicrobial Susceptibility Pattern, and Associated Risk Factors Among Patients With Wound Infections at Debre Markos Referral Hospital, Northwest, Ethiopia

“…[5][6][7] Patients with wounds are more vulnerable to infection due to the loss of the normal protective skin barrier, impaired immune system, and the presence of dead and necrotic tissues that provide an environment conducive to the growth and proliferation of pathogens. 8 The most common types of skin and soft tissue infections include impetigo, folliculitis, cellulites, abscess formation, and so on. 9,10 Wound infection that is caused by multidrug-resistant (MDR) bacteria leads to long hospital stays, high cost expenditure, body deformity, and significant human morbidity and mortality.…”

“…5-7 Patients with wounds are more vulnerable to infection due to the loss of the normal protective skin barrier, impaired immune system, and the presence of dead and necrotic tissues that provide an environment conducive to the growth and proliferation of pathogens. 8…”

Effect of Antibiotic Prophylaxis on Infectious Complications in Patients with Asymptomatic Bacteriuria Undergoing Urologic Surgery

“…The fact that a patient has been hospitalized is a factor that is associated with healthcare-related infections, due to exposure to invasive devices, contact with healthcare personnel, and use of antibiotics. 21,22 In our study, postsurgical infectious complications were greater among patients who underwent hospitalization in the 3 months immediately preceding the urologic procedure.…”