Risk factors and clinical significance of prechoroidal cleft in eyes with neovascular age‐related macular degeneration in Caucasian patients

Abstract

Age-related macular degeneration (AMD) is a leading cause of visual loss in people older than 65 years old worldwide (Friedman et al. 2004). Neovascular AMD (nAMD) is characterized by the presence of macular neovascularization (MNV) and is responsible for the majority of severe visual impairment due to AMD

Prechoroidal Cleft Regression After Switch to Intravitreal Brolucizumab

“…Prechoroidal cleft has been reported to occur in 8,1 to 22,3% of nAMD patients 3,4 (15% in a single report for Caucasian population). 5 This peculiar finding was first defined in a retrospective series of Asian patients diagnosed with nAMD (Type 1,2 and 3 MNV). The authors proposed that this anatomic space might be the result of fluid accumulation arising from active MNV components within the materials in PEDs.…”

“…This biomarker has been described as an independent risk factor for the formation of RPE rips, subretinal hemorrhages and fibrotic scars. [2][3][4][5] Although the complete pathogenic mechanism leading to the onset of this peculiar lesion is still controversial, overall, this AMD phenotype should be considered a risk factor for poorer long-term visual prognosis. To date, no histopathologic study has been conducted with a specific focus on this topic.…”

“…To date, only a limited number of studies have investigated the treatment options and outcomes of this peculiar finding. 1,5,7,8,13 Case report A 63-year-old female patient presented with unilateral metamorphopsia to the University Eye Clinic of Genoa (Italy). Baseline BCVA was 20/32 in the right eye and 20/20 in the left eye.…”

“…This biomarker has been described as an independent risk factor for the formation of RPE rips, subretinal hemorrhages and fibrotic scars. 2–5…”

“…To date, only a limited number of studies have investigated the treatment options and outcomes of this peculiar finding. 1,5,7,8,13…”