Risk factors and clinical aspects associated with hepatocellular carcinoma: role of long noncoding RNAs

Kodidela, Swarnalatha; Behera, Abhayananda; Reddy, Aramati B. M.

doi:10.1016/b978-0-323-98806-3.00020-9

Cited by 2 publications

(2 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple lncRNAs, for example, UCA1 and WRAP53, in combination with AFP, ensure up to 100 percent responsiveness [ 307 ]. Similarly, combining two lncRNAs, PVT1 and uc002mbe.2, along with AFP, has been shown to serve well in the diagnosis of HCC relative to AFP alone [ 195 , 308 ].…”

Section: Lncrnas As Diagnostic and Therapeutic Markers In Hccmentioning

confidence: 99%

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials

Khan

Zhang

2022

Bioengineering

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the most common and serious type of primary liver cancer. HCC patients have a high death rate and poor prognosis due to the lack of clear signs and inadequate treatment interventions. However, the molecular pathways that underpin HCC pathogenesis remain unclear. Long non-coding RNAs (lncRNAs), a new type of RNAs, have been found to play important roles in HCC. LncRNAs have the ability to influence gene expression and protein activity. Dysregulation of lncRNAs has been linked to a growing number of liver disorders, including HCC. As a result, improved understanding of lncRNAs could lead to new insights into HCC etiology, as well as new approaches for the early detection and treatment of HCC. The latest results with respect to the role of lncRNAs in controlling multiple pathways of HCC were summarized in this study. The processes by which lncRNAs influence HCC advancement by interacting with chromatin, RNAs, and proteins at the epigenetic, transcriptional, and post-transcriptional levels were examined. This critical review also highlights recent breakthroughs in lncRNA signaling pathways in HCC progression, shedding light on the potential applications of lncRNAs for HCC diagnosis and therapy.

show abstract

Section: Lncrnas As Diagnostic and Therapeutic Markers In Hccmentioning

confidence: 99%

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials

Khan

Zhang

2022

Bioengineering

View full text Add to dashboard Cite

show abstract

“…RNA interference (RNAi), another epigenetic regulator, plays a crucial role in gene regulation, including the suppression or silencing of specific genes or their messenger RNA (mRNA) products [ 14 , 15 ]. MicroRNAs (miRNAs), a subset of non-coding RNAs, emerge as key players in fine-tuning gene expression and responding to physiological and environmental signals.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-mediated epigenetic regulation of HDAC8 and HDAC6: Functional significance in cervical cancer

Naik,

Kalle

2024

Non-coding RNA Research

View full text Add to dashboard Cite

Risk factors and clinical aspects associated with hepatocellular carcinoma: role of long noncoding RNAs

Cited by 2 publications

References 85 publications

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials

Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials

MicroRNA-mediated epigenetic regulation of HDAC8 and HDAC6: Functional significance in cervical cancer

Contact Info

Product

Resources

About