Risk factor profile of cerebral small vessel disease and its subtypes

Abstract

SVD has a different risk factor profile from the typical atherosclerotic profile found in LVD, with hypertension being important. There are differences in the risk factor profile between the SVD subtypes; the association of ILI with hypercholesterolaemia, diabetes and myocardial infarction may be consistent with a more atherosclerotic aetiology.

Carotid Artery Wall Thickness and Leukoaraiosis: Preliminary Results Using Multidetector Row CT Angiography

“…However, the association between LA and cerebrovascular risk factors is still being debated; Murray et al 56 found a significant Pearson correlation between LA and diabetes, hypertension, low-attenuation lipoprotein, and cholesterol, but these associations were not confirmed by other authors. 57 An interesting result observed in our study was the association between the presence of the fatty plaque type and LA (P ϭ 0.0276). It is well known that the composition of the atherosclerotic plaque may play a significant role in the origin of cerebrovascular events.…”

N-Acetylaspartate/Creatine and Choline/Creatine Ratios in the Thalami, Insular Cortex and White Matter as Markers of Hypertension and Cognitive Impairment in the Elderly

“…Hypertension, found in 65% of all subjects in the Three-City Study (11), is the main risk factor for cerebral small vessel disease (20). Cerebral small vessel disease induces silent ischemia in both the perforating arteries of the thalami and the leptomeningeal or cortical vessels of the insula.…”

Classification of White Matter Lesions on Magnetic Resonance Imaging in Elderly Persons

“…SVD has different risk factors from large vessel diseases. Hypertension is more common in SVD than large vessel diseases, whereas hypercholesterolemia, smoking, myocardial infarction and peripheral vascular disease are more common in large vessel diseases (64). Hypertension may induce fibrohyalinosis with thickening of the wall and narrowing of the vascular lumen on the small penetrating arteries and arterioles of the white matter.…”