Risk Factor Analysis of Graft Failure With Concomitant Cyst Enucleation of the Jaw Bone: A Retrospective Multicenter Study

Lim, Ho-Kyung; Kim, Jin Woo; Lee, Ui‐Lyong; Kim, Ju Won; Lee, Ho

doi:10.1016/j.joms.2017.02.003

Cited by 23 publications

(15 citation statements)

References 42 publications

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“…The authors have previously suggested factors that affect graft failure during enucleation [ 24 ]. Graft failure with concomitant cyst enucleation could increase in cases of younger age, smoking, preoperative infection, large size, impaction of the mandibular third molar, perilesional osteosclerosis, and the use of mixed non-autogenous and autogenous bone [ 24 ]. In this study on decompression, it was confirmed that cases of long period, in younger patients, and in the posterior maxilla showed more volume reduction effect.…”

Section: Discussionmentioning

confidence: 99%

Effect of Decompression on Jaw Cystic Lesions Based on Three-Dimensional Volumetric Analysis

Kwon

et al. 2020

Medicina

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Background and objectives: This study aimed to evaluate the effectiveness of decompression on jaw cysts according to various parameters by volumetric analysis using three-dimensional computed tomography. Materials and methods: Fifty patients who underwent surgical decompression of the jaw cystic lesion were selected, and their preoperative and postoperative computed tomography results between 3 and 27 months were collected. Volumetric analysis was performed to evaluate any differences in the rate of volumetric change according to the sex, age, initial volume of the lesion, duration, location of the lesion, tooth extraction, expansion of the cortical layer, and pathological diagnosis. Multiple linear regression and generalised linear mixed models were used for statistical analyses. Results: The mean reduction rate among all patients was 54.68%. Multiple linear regression analysis revealed that higher reduction rates were associated with a long decompression period, young patient age, and location of the cyst in the posterior maxilla. Generalised linear mixed models revealed that higher reduction rates were associated with a long decompression period and young patient age. Conclusions: Decompression was an effective treatment for reducing the cyst size in all patients. Its effectiveness increased with a long treatment duration, young patient age, and cyst location in the posterior maxilla three-dimensionally.

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Section: Discussionmentioning

confidence: 99%

Effect of Decompression on Jaw Cystic Lesions Based on Three-Dimensional Volumetric Analysis

Kwon

et al. 2020

Medicina

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“…A retrospective multicentric research conducted by Lim (2017) made it possible to group the factors that, according to the analysis of authors, to the greatest extent lead to the loss of bone augmentation after the procedure for the exclusion of cysts in the maxillofacial area 25 . The use of the method of multivariant regression analysis contributed to the possibility of numerical representation of the increase in the relative risk of augmentation-associated complications after filling the defect site with a bone substitute, in the following cases: at a young age of the patient (relative risk -1.033), in smoking (relative risk -2.698), under post-operative infections (relative risk -4.660), at large cysts (relative risk -1.052), in case of sclerosis of the surrounding walls of the defect (relative risk -4.973), when using mixtures with autologous bone tissue or autologous augmentation in general (relative risk -3.891).…”

Section: Discussionmentioning

confidence: 99%

“…The use of the method of multivariant regression analysis contributed to the possibility of numerical representation of the increase in the relative risk of augmentation-associated complications after filling the defect site with a bone substitute, in the following cases: at a young age of the patient (relative risk -1.033), in smoking (relative risk -2.698), under post-operative infections (relative risk -4.660), at large cysts (relative risk -1.052), in case of sclerosis of the surrounding walls of the defect (relative risk -4.973), when using mixtures with autologous bone tissue or autologous augmentation in general (relative risk -3.891). The latter risk factor is substantiated by the possibility of preliminary infection of the autologous material at the stage of its collection, which, if it is further blended with augmentation of another origin or isolated use, can automatically lead to the subsequent infection of the entire site of intervention [23][24][25] . From this point of view, the use of non-autological materials (collagen sponge or fibrous matrix) in order to fill bone defects formed as a result of enucleation is more appropriate.…”

Section: Discussionmentioning

confidence: 99%

Microcirculation changes in the area of restoration of osseous defects of jaws using polymeric fibrous matrix

Pantus¹,

SLYUSARENKO²,

Kovalchuk³

et al. 2019

Arch Balk Med Union

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Changements de la microcirculation dans la zone de restauration des défauts osseux des mâchoires à l'aide d'une matrice fibreuse polymère Introduction. L'un des domaines les plus spécifiques de la stomatologie pratique est l'utilisation de diverses structures de matrice biologique servant comme une épine dorsale aux cellules ostéogéniques et de cadre aux composants vasculaires assurant la formation progressive d'un nouveau tissu osseux dans la zone de défaut formée par l'énucléation résultante. Objectif. Établir l'efficacité de l'utilisation de la matrice fibreuse et de la membrane polymère dans le processus de restauration des défauts de la structure osseuse après la procédure d'énucléation sur la mâchoire inférieure et analyser les résultats avec ceux enregistrés lors de la réalisation de défauts osseux avec une éponge de collagène.

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“…However, it takes quite a long time for DC to reach recovery under marsupialization. To shorten the course of treatment, suction drainage has been applied to clinic, but problems are still tough about the inconvenience and infection brought by suction drainage devices (8).…”

Section: Introductionmentioning

confidence: 99%

Activation of Mesenchymal Stem Cells Promotes New Bone Formation Within Dentigerous Cyst

Zhou

et al. 2020

Preprint

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Background: Dentigerous cyst (DC) is a bone destructive disease and remains a challenge for clinicians. Marsupialization enables bone to regenerate with capsules maintaining, making it a preferred therapeutic means for DC adjacent to vital anatomical structures. Given that capsules of DC derive from odontogenic epithelium remnants at embryonic stage, we investigated whether there were mesenchymal stem cells (MSCs) located in DC capsules and the role that they played in the bone regeneration after marsupialization.Methods: Samples obtained before and after marsupialization were used for histological detection and cell culture. The stemness of cells isolated from fresh tissues were analyzed by morphology, surface marker and multi-differentiation assays. Comparison of proliferation ability between Am-DCSCs and Bm-DCSCs were evaluated by Cell Counting Kit-8 (CCK-8), fibroblast colony-forming units (CFU-F) and 5’‐ethynyl‐2’‐deoxyuridine (EdU) assay. Their osteogenic capacity in vitro was detected by Alkaline phosphatase (ALP) and Alizarin Red staining (ARS), combined with Real-time polymerase chain reaction (RT-PCR) and immunofluorescence (IF) staining. Subcutaneous ectopic osteogenesis as well as cranial bone defect model in nude mice were performed to detect their bone regeneration and bone defect repair ability.Results: Bone tissue and strong ALP activity were detected in the capsule of DC after marsupialization. Two types of MSCs were isolated from fibrous capsules of DC both before (Bm-DCSCs) and after (Am-DCSCs) marsupialization. These fibroblast-like, colony forming cells expressed MSC markers (CD44+, CD90+, CD31-, CD34-, CD45-), and they could differentiate into osteoblast-, adipocyte- and chondrocyte-like cells under induction. Notably, Am-DCSCs performed better in cell proliferation and self-renewal. Moreover, Am-DCSCs showed greater osteogenic capacity both in vitro and in vivo compared with Bm-DCSCs. Conclusions: There are MSCs residing in capsules of DC, and the cell viability as well as osteogenic capacity of them are largely enhanced after marsupialization. Our findings suggested that MSCs might play a crucial role in the healing process of DC after marsupialization, thus providing new insight into the treatment for DC by promoting the osteogenic differentiation of MSCs inside capsules.

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Risk Factor Analysis of Graft Failure With Concomitant Cyst Enucleation of the Jaw Bone: A Retrospective Multicenter Study

Cited by 23 publications

References 42 publications

Effect of Decompression on Jaw Cystic Lesions Based on Three-Dimensional Volumetric Analysis

Effect of Decompression on Jaw Cystic Lesions Based on Three-Dimensional Volumetric Analysis

Microcirculation changes in the area of restoration of osseous defects of jaws using polymeric fibrous matrix

Activation of Mesenchymal Stem Cells Promotes New Bone Formation Within Dentigerous Cyst

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