Risk factor analysis and molecular epidemiology of respiratory adenovirus infections among children in northern Taiwan, 2009–2013

Cheng, Jia; Peng, Chun-Chih; Chiu, Nan-Chang; Weng, Li-Chuan; Chiu, Yu-Ying; Chang, Lung; Huang, Fu‐Yuan; Liu, Chang-Pan; Chi, Hsin

doi:10.1016/j.jmii.2015.08.006

Cited by 33 publications

(41 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pneumonia was also the most common clinical diagnosis (89%), with half of these patients subsequently developing respiratory failure. A previous study suggested that HAdV-7 is strongly related to severe infections, pneumonia and underlying neurological diseases and is a risk factor for severe HAdV infection [32].…”

Section: Discussionmentioning

confidence: 99%

Clinical and molecular features of adenovirus type 2, 3, and 7 infections in children in an outbreak in Taiwan, 2011

Lin

Yang

Gong

et al. 2017

Clinical Microbiology and Infection

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical and molecular features of adenovirus type 2, 3, and 7 infections in children in an outbreak in Taiwan, 2011

Lin

Yang

Gong

et al. 2017

Clinical Microbiology and Infection

View full text Add to dashboard Cite

show abstract

“…According to literature, most frequent symptoms associated with severe adenoviral pneumonia are prolonged fever, respiratory compromise with hypoxia and rapid deterioration of clinical condition, requiring intubation and ventilation [20,21]; bilateral interstitial infiltrates are the most common radiological findings [1,4,7]. Lymphopenia, thrombocytopenia and elevated transaminases levels are frequently observed.…”

Section: Discussionmentioning

confidence: 99%

“…Human adenoviruses (HAdVs) are non enveloped, double stranded DNA viruses usually causing acute febrile and self-limiting respiratory infections in children [1,4]. Severe infections are usually observed in neonates [2] and immunocompromised adults, such as HIV-positive individuals or transplanted patients [3,5].…”

Section: Why This Case Is Important?mentioning

confidence: 99%

Acute respiratory distress syndrome in adenovirus type 4 pneumonia: A case report

Narra

Bono

Zoccoli

et al. 2016

Journal of Clinical Virology

View full text Add to dashboard Cite

“…Outbreaks of adenoviral pneumonia have been occasionally reported in young adult women or military personnel [5][6][7][8][9]. Respiratory tract infection is the leading cause of hospitalization of military trainees in the medical field.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community-acquired pneumonia

Yoo

Park

2020

Military Med Res

View full text Add to dashboard Cite

Background: In 2014, an outbreak of adenoviral pneumonia occurred in the Korean military training center. However, there are limited data on the characteristics of the fever and its response to antipyretic therapy in immunocompetent adults with adenovirus-positive community-acquired pneumonia (CAP). Methods: The medical records of the patients who were admitted to the Armed Forces Chuncheon Hospital for the treatment of CAP between January 2014 and December 2016 were retrospectively analyzed. The patients were divided into three groups, namely, the adenovirus-positive (Adv) group, the adenovirus-negative (Non-Adv) group and the unknown pathogen group, according to the results of a polymerase chain reaction (PCR) test and sputum culture used to measure adenovirus and other bacteria or viruses in respiratory specimens. We evaluated and compared the demographics, clinicolaboratory findings and radiological findings upon admission between the two groups. Results: Out of the 251 military personnel with CAP during the study periods, 67 were classified into the Adv group, while 134 were classified into the Non-Adv group and 50 were classified into the unknown pathogen group. The patients in the Adv group had a longer duration of fever after admission (3.2 ± 1.6 vs. 1.9 ± 1.2 vs. 2.2 ± 1.5 days, P = 0.018) and symptom onset (5.8 ± 2.2 vs. 3.9 ± 2.5 vs. 3.7 ± 2.0 days, P = 0.006) than patients in the Non-Adv and unknown pathogen groups, respectively. The patients in the Adv group had a higher mean temperature at admission (37.8 ± 0.3 vs. 37.3 ± 0.3 vs. 37.3 ± 0.3, P = 0.005), and more patients were observed over 40 and 39 to 40(14.9% vs. 2.2% vs. 4.0%, 35.8% vs. 3.7% vs. 6.0%, P < 0.001) than those in the Non-Adv and unknown pathogen groups, respectively. The Adv group more commonly had no response or exhibited adverse events after antipyretic treatment compared to the Non-Adv group (17.9% vs. 1.5%, 35.0% vs. 4.3%, P < 0.001, P = 0.05, respectively). In addition, the time from admission to overall clinical stabilization was significantly longer in the patients in the Adv group than in those in the Non-Adv group (4.3 ± 2.8 vs. 2.9 ± 1.8 days, P = 0.034, respectively). Furthermore, no significant difference in the length of hospital stay was observed between the two groups, and no patient died in either group. Conclusion: In this study, Adv-positive CAP in immunocompetent military personnel patients had distinct fever characteristics and responses to antipyretic treatment.

show abstract

Risk factor analysis and molecular epidemiology of respiratory adenovirus infections among children in northern Taiwan, 2009–2013

Abstract: HAdV infections circulate all year-round. HAdV B7 is strongly related to severe infections and pneumonia. Underlying neurologic diseases and prematurity are risk factors for severe HAdV infections.

Cited by 33 publications

References 22 publications

Clinical and molecular features of adenovirus type 2, 3, and 7 infections in children in an outbreak in Taiwan, 2011

Clinical and molecular features of adenovirus type 2, 3, and 7 infections in children in an outbreak in Taiwan, 2011

Acute respiratory distress syndrome in adenovirus type 4 pneumonia: A case report

Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community-acquired pneumonia

Contact Info

Product

Resources

About