Risk evaluation of ampicillin/sulbactam-induced liver injury based on albumin-bilirubin score

Ooi, Hayahide; Asai, Yukako; Sato, Yoshiharu

doi:10.1016/j.jiac.2023.06.003

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…Our previous reports have revealed that the ALBI score may be risk factor for micafungin-, 11) doripenem-, 12) ampicillin/sulbactam- 13) induced liver injury. Moreover, the ALBI score is used for the prediction of mortality in valvular surgery, 17) heart failure, 18) and idiopathic dilated cardiomyopathy.…”

Section: Discussionmentioning

confidence: 99%

“…The exclusion criteria of the present study were as follows: (I) multiple administrations of CTRX treatment in the same patient, (II) patients <18 years old, (III) duration of treatment <5 d, (IV) missing baseline data, and (V) baseline alanine aminotransferase (ALT) and/or alkaline phosphatase (ALP) levels more than twice the upper limit of normal (ULN) as in previous studies. [11][12][13] The DDW-J scale has been frequently used to diagnose drug-induced liver injury. 14) On this scale, druginduced liver injury during treatment is defined as: 5-90 d is 2 points, and <5 and >90 d is 1 point.…”

Section: Study Participants and Exclusion Criteriamentioning

confidence: 99%

“…In COX regression analysis, CTRX-induced liver injury was used as an independent variable. Because ALT, 12) ALBI score, [11][12][13] and CTRX dosage 5) may be involved in liver injury, we selected these as explanatory factors. The association between ALBI score and liver injury was examined with adjustment for (model 1) except the dosage of CTRX, (model 2) ALBI score and 4 g/d of CTRX, (model 3) ALBI score and ≥2 g/d of CTRX, and (model 4) ALBI score and 1 g/d of CTRX.…”

Section: Study Participants and Exclusion Criteriamentioning

confidence: 99%

“…The albumin-bilirubin (ALBI) score, calculated from serum albumin and total bilirubin levels, 8) is an objective index of hepatic functional reserve used for predicting the prognosis of hepatocellular carcinoma (HCC). 9) An increase in ALBI score is correlated with a decrease in hepatic functional reserve, 10) and may be associated with micafungin-, 11) doripenem-, 12) and ampicillin/sulbactam- 13) induced liver injury in non-HCC patients, suggesting that the ALBI score may be a predictive index for CTRX-induced liver injury. However, the relationship between the ALBI score and CTRX-induced liver injury remains unknown.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Ceftriaxone Dosage and Albumin–Bilirubin Score on the Risk of Ceftriaxone-Induced Liver Injury

Ooi,

Asai,

Koriyama

et al. 2023

Biological & Pharmaceutical Bulletin

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The albumin-bilirubin (ALBI) score is an index of hepatic functional reserve and is calculated from serum albumin and total bilirubin levels. However, the relationship between ceftriaxone (CTRX)-induced liver injury and ALBI score remains unknown. Therefore, we aimed to elucidate the risk of CTRX-induced liver injury based on the ALBI scores and CTRX dosage. This was a single-center, retrospective, case-control study of 490 patients and the primary outcome was CTRX-induced liver injury. We performed a COX regression analysis using age ≥75 years, male sex, alanine aminotransferase levels, ALBI score, and CTRX dosage regimen (4 ≥2 or 1 g/d) as explanatory factors. We also performed 1 : 1 propensity score matching between non-liver injury and liver injury groups. The incidence of liver injury was 10.0% (49/490). In COX regression analysis, CTRX 4 g/d was an independent risk factor for liver injury (95% coefficient interval: 1.05-6.96, p 0.04). Meanwhile, ALBI score ≥ 1.61 was an independent factor for liver injury (95% coefficient interval: 1.03-3.22, p 0.04) with the explanatory factor of ≥2 and 1 g/d. The Kaplan-Meier curve indicated that the cumulative risk for CTRX-induced liver injury was significantly higher in the ALBI score ≥ 1.61 group than in the ALBI score < 1.61 group before propensity score matching (p 0.032); however, no significant differences were observed after propensity score matching (p 0.791). These findings suggest that in patients treated with CTRX with ALBI score ≥ 1.61, frequent liver function monitoring should be considered.

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Section: Discussionmentioning

confidence: 99%

Section: Study Participants and Exclusion Criteriamentioning

confidence: 99%

Section: Study Participants and Exclusion Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Ceftriaxone Dosage and Albumin–Bilirubin Score on the Risk of Ceftriaxone-Induced Liver Injury

Ooi,

Asai,

Koriyama

et al. 2023

Biological & Pharmaceutical Bulletin

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Decreased Hepatic Functional Reserve Increases the Risk of Piperacillin/Tazobactam-Induced Abnormal Liver Enzyme Levels: A Retrospective Case-Control Study

Ooi,

Asai,

Koriyama

et al. 2024

Ann Pharmacother

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Background: Piperacillin/tazobactam (PIPC/TAZ), which is a combination of a beta-lactam/beta-lactamase inhibitor, often causes liver enzyme abnormalities. The albumin-bilirubin (ALBI) score is a simple index that uses the serum albumin and total bilirubin levels for estimating hepatic functional reserve. Although patients with low hepatic reserve may be at high risk for drug-induced liver enzyme abnormalities, the relationship between PIPC/TAZ-induced abnormal liver enzymes levels and the ALBI score remains unknown. Objective: This study aimed to elucidate the relationship between PIPC/TAZ-induced abnormal liver enzyme levels and the ALBI score. Methods: This single-center retrospective case-control study included 335 patients. The primary outcome was PIPC/TAZ-induced abnormal liver enzyme levels. We performed COX regression analysis with male gender, age (≥75 years), alanine aminotransferase level (≥20 IU/L), and ALBI score (≥−2.00) as explanatory factors. To investigate the influence of the ALBI score on the development of abnormal liver enzyme levels, 1:1 propensity score matching between the ≤−2.00 and ≥−2.00 ALBI score groups was performed using the risk factors for drug-induced abnormal liver enzyme levels. Results: The incidence of abnormal liver enzyme levels was 14.0% (47/335). COX regression analysis revealed that an ALBI score ≥−2.00 was an independent risk factor for PIPC/TAZ-induced abnormal liver enzyme levels (adjusted hazard ratio: 3.08, 95% coefficient interval: 1.207-7.835, P = 0.019). After 1:1 propensity score matching, the Kaplan-Meier curve revealed that the cumulative risk for PIPC/TAZ-induced abnormal liver enzyme levels was significantly higher in the ALBI score ≥−2.00 group (n = 76) than in the <−2.00 group (n = 76) ( P = 0.033). Conclusion and relevance: An ALBI score ≥−2.00 may predict the development of PIPC/TAZ-induced abnormal liver enzyme levels. Therefore, frequent monitoring of liver enzymes should be conducted to minimize the risk of severe PIPC/TAZ-induced abnormal liver enzyme levels in patients with low hepatic functional reserve.

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Risk evaluation of ampicillin/sulbactam-induced liver injury based on albumin-bilirubin score

Cited by 2 publications

References 22 publications

Effect of Ceftriaxone Dosage and Albumin–Bilirubin Score on the Risk of Ceftriaxone-Induced Liver Injury

Effect of Ceftriaxone Dosage and Albumin–Bilirubin Score on the Risk of Ceftriaxone-Induced Liver Injury

Decreased Hepatic Functional Reserve Increases the Risk of Piperacillin/Tazobactam-Induced Abnormal Liver Enzyme Levels: A Retrospective Case-Control Study

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