Risk Evaluation and Molecular Biomarkers Identification of Firefighter Suffering Lung Cancer Via the TCGA Database

Abstract

To evaluate the risk of firefighters suffering lung cancer after a long-term career and identify novel molecule biomarkers for evaluation, we tested the composition of flame-resistance door combustion byproducts. The results showed that the main component of combustion byproducts was PAHs and VOCs. The ceRNAs network showed that 26 mRNAs, 18 miRNAs, and 141 lncRNAs were involved in the lung cancer process. Most of the ceRNAs in our study could be affected by PAHs and VOCs. The Kaplan-Meier plots of differentially expressed RNAs in the ceRNA network showed that 3 mRNAs, 4 miRNAs, and 13lncRNAs have a relationship with the survival time of lung cancer patients. We recommended that mRNA COL1A1, CCBN1, and PFKP; miRNA hsa-miR-143, hsa-miR-183, hsa-miR-144, hsa-miR-372 and hsa-miR-373; lncRNA UCA1, TTTY16, LSAMP-AS1, LINC00337 and LNX1-AS1 as a biomarker to evaluate the risk of a firefighter suffering lung cancer and other cancers.