Risk Effects of GST Gene Polymorphisms in Patients with Acute Myeloid Leukemia: A Prospective Study

Zhou, Lei; Zhu, Yanyun; Zhang, Xiaodong; Yang, Li; Liu, Zhuogang

doi:10.7314/apjcp.2013.14.6.3861

Cited by 27 publications

(23 citation statements)

References 21 publications

(22 reference statements)

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“…Such cancers include lung cancer (Mir Muhammad NasirUddin, 2014), ovarian cancer (Coughlin and Hall, 2002) and breast cancer (Hashemi et al, 2012). Previous studies have reported about GSTs association with heamatological malignancy, but with conflicting findings as mentioned previously (Dunna et al, 2012;Zhou et al, 2013;Rostami internal positive control.…”

Section: Discussionmentioning

confidence: 99%

“…(Hashemi et al, 2012). The GSTM1 null and GSTT1 null appear to be associated with a significant risk of several types of cancers, such as hematological neoplasm (Banescu et al, 2014;Sailaja et al, 2010;Zhou et al, 2013) and breast cancer (Hashemi et al, 2012). It has been shown that the risk of ALL is doubled in patients who carry the GSTM1 deletion (Joseph et al, 2004).…”

Section: Genotypesmentioning

confidence: 99%

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Genetic Polymorphism of GSTP1, GSTM1 and GSTT1 Genes and Susceptibility to Chronic Myeloid Leukaemia

Idris

Elderdery

Khalil

et al. 2020

Asian Pac J Cancer Prev

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Background: The development of cancer results from an imbalance between exposure to carcinogens and the capacity of various enzyme systems engaged in activation or in the detoxification of xenobiotics. The aim of the present study is to investigate the association of GSTP1, GSTM1 and GSTT1 gene polymorphisms in susceptibility to Chronic Myeloid Leukaemia (CML). Methods: A total of 200 CML patients and 100 controls were enrolled in a case-control study with GSTM1 and GSTT1 analysis with PCR and GSTP1 analysis with PCR-RFLP. Results: The GSTT1 null genotype was significantly higher among CML patients suggesting that this genotype is associated with an increased risk of CML. It was found in 42% of cases as compared with 21% of the controls, (OR =2.78, 95% CI: 1.59-4.85; p-value =0.000). The presence of the GSTT1 genotype may thus be considered a protective factor for CML. The frequency of individuals carrying GSTM1 null genotype was slightly higher in the control group but this difference was not statistically significant. The GSTM1 null genotype was present in 35% of control cases and 34% of the CML patients, (OR=0.975, 95%CI: 0.58-1.58;p-value=0.863). Individuals with a combined GSTM1 null/GSTT1null genotype had an estimated 2.85-fold increased risk of CML, but no associated risk between GSTP1 Ile 105 Val polymorphism and CML was found (OR=1.99, 95% CI: 0.40-9.32; p-value = 0.417). Conclusions: No association between GSTP1 and GSTM1 with susceptibility to CML was found. GSTT1 genotype may be a protective factor for CML, while the null genotype shows association with developing CML.

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Section: Discussionmentioning

confidence: 99%

Section: Genotypesmentioning

confidence: 99%

Genetic Polymorphism of GSTP1, GSTM1 and GSTT1 Genes and Susceptibility to Chronic Myeloid Leukaemia

Idris

Elderdery

Khalil

et al. 2020

Asian Pac J Cancer Prev

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“…Detailed process for selecting eligible studies was showed in Figure 1. Among these, two studies (Dunna et al, 2012;Zhou et al, 2013) were excluded for HWE deviation. Finally, 23 studies, which control individuals did not departure from HWE (P-value of HWE >0.05, respectively), were included in the metaanalysis.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis

Tang

Zhang²,

Pan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Acute myeloid leukemia (AML) is a clonal disorder that is characterized by the abnormal accumulation of white blood cells in the bone marrow and which interferes with the normal production of blood cells (1). The etiology of AML was found to be multifactorial; however, exposure to carcinogens such as benzene and ionizing radiation is thought to result in DNA damage at the level of hematopoietic progenitor cells, which is an essential prerequisite for the development of AML (2).…”

Section: Introductionmentioning

confidence: 99%

“…The distribution of the GSTP1 Ile105Val genotypes in controls was not in accordance with the HWE in five studies and hence, they were excluded (1,11,16,31,35). A meta-analysis was conducted using the data of 852 cases and 2339 controls from additional five studies under the allele contrast (Fig.…”

mentioning

confidence: 99%

Glutathione S-transferase Gene Polymorphisms and Susceptibility to Acute Myeloid Leukemia: Meta-analyses

You

Sun

et al. 2014

Japanese Journal of Clinical Oncology

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Objective: A large body of evidence has shown the possible relevance of polymorphisms of the genes that encode glutathione S-transferase m, p and u (GSTM1, GSTP1 and GST1, respectively) to the susceptibility of acute myeloid leukemia, but the exact association still remains uncertain. Therefore, we performed a meta-analysis to derive a more precise estimation of the relationship. Methods: A comprehensive literature search of PubMed and Web of Knowledge electronic databases was conducted to collect relevant studies until 20 February 2014. References of the retrieved articles were also screened. The extracted data were statistically analyzed, and pooled odds ratios with 95% confidence intervals were calculated to estimate the association strength using Review Manager version 5.2. Results: Twenty-nine studies were included in the meta-analysis. The pooled analyses revealed that the GSTM1-null genotype was associated with an increased risk of acute myeloid leukemia in East Asians (P ¼ 0.01; odds ratio ¼ 1.22; 95% confidence interval ¼ 1.05 -1.42), and GSTT1-null genotype in Caucasians (P , 0.0001; odds ratio ¼ 1.48; 95% confidence interval ¼ 1.29 -1.69). There was also a predilection towards the female gender for both of these polymorphisms. For GSTP1 Ile105Val polymorphism, no significant association was found under any contrast model. In addition, the presence of the double-null genotypes increased the risk of acute myeloid leukemia in both Caucasians and East Asians. Conclusions: This meta-analysis suggested that heritable GST status could influence the risk of developing acute myeloid leukemia.

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Risk Effects of GST Gene Polymorphisms in Patients with Acute Myeloid Leukemia: A Prospective Study

Cited by 27 publications

References 21 publications

Genetic Polymorphism of GSTP1, GSTM1 and GSTT1 Genes and Susceptibility to Chronic Myeloid Leukaemia

Genetic Polymorphism of GSTP1, GSTM1 and GSTT1 Genes and Susceptibility to Chronic Myeloid Leukaemia

Glutathione-S-Transferase Polymorphisms (GSTM1, GSTT1 and GSTP1) and Acute Leukemia Risk in Asians: a Meta-analysis

Glutathione S-transferase Gene Polymorphisms and Susceptibility to Acute Myeloid Leukemia: Meta-analyses

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