Risk constellations prior to the development of bipolar disorders: Rationale of a new risk assessment tool

Leopold, Karolina; Ritter, Philipp; Correll, Christoph U.; Marx, Carolin; Özgürdal, Seza; Juckel, Georg; Bauer, Michael; Pfennig, Andrea

doi:10.1016/j.jad.2011.06.043

Cited by 94 publications

(172 citation statements)

References 91 publications

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“…In a recent study, dissociative symptoms were operationalized as a risk factor for a new risk assessment instrument 14 . DES scores were similar between BD-I and BD-II 15 .…”

Section: Discussionmentioning

confidence: 99%

Dissociative experiences in bipolar disorder II: Are they related to childhood trauma and obsessive-compulsive symptoms?

Eryılmaz¹,

Kesebir²,

Gül³

et al. 2015

Arch. Clin. Psychiatry (São Saulo)

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Objective: The aim of this study is to investigate the presence of dissociative symptoms and whether they are related to childhood trauma and obsessive--compulsive symptoms in bipolar disorder type II (BD-II). Methods: Thirty-three euthymic patients (HDRS<8, YMRS<5) and 50 healthy subjects were evaluated by SCID-I and SCID-NP. We excluded all first and second-axis comorbidities. All patients and healthy subjects were examined with the Dissociative Experiences Scale (DES), Childhood Trauma Questionnaire (CTQ-53), and Yale-Brown Obsessive-Compulsive Disorder scale (Y-BOCS). Results: In pairwise comparisons between the BD-II and control groups, the total CTQ, emotional abuse, emotional neglect, DES, and total Y-BOCS scores in the BD-II group were significantly higher than those in the control group (p < 0.05). There were five cases with DES scores over 30 (15.2%) and one case (2%) in the control group. DES was weakly correlated with total CTQ and Y-BOCS in patients diagnosed with BD-II (r = 0.278, p < 0.05 and r = 0.217, p < 0.05, respectively). While there was no correlation between total CTQ and Y-BOCS, the CTQ sexual abuse subscale was found to be related to Y-BOCS (r = 0.330, p < 0.05). Discussion: These results suggest that there is a relation between childhood traumas and obsessive-compulsive symptoms, or that dissociative symptoms are more associated with anxiety than obsessive symptoms, which prevents the increase of obsessive-compulsive symptoms in BD-II.Eryilmaz G et al. / Arch Clin Psychiatry. 2015;42(2):38-40

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“…In a recent study, dissociative symptoms were operationalized as a risk factor for a new risk assessment instrument 14 . DES scores were similar between BD-I and BD-II 15 .…”

Section: Discussionmentioning

confidence: 99%

Dissociative experiences in bipolar disorder II: Are they related to childhood trauma and obsessive-compulsive symptoms?

Eryılmaz¹,

Kesebir²,

Gül³

et al. 2015

Arch. Clin. Psychiatry (São Saulo)

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“…The higher rate of comorbidity and risk of unemployment and suicide increase the burden of the disease (Fajutrao et al 2009). As late diagnosis of the disorder heightens its impact (Leopold et al 2012), screening tools could be extremely useful. Bipolar Disorder manifests early, in adolescence and early adulthood.…”

Section: Introductionmentioning

confidence: 99%

Screening for bipolar disorders: A public health issue

Carta

Angst

2016

Journal of Affective Disorders

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“…However, despite the urgency to develop rating instruments and criteria for the prodromal, i.e., sub-syndromal and sub-threshold presentations of BP-I, which is required to validate risk criteria in prospective studies and test early interventions, as has been done successfully in psychosisresearch 11–14 , these developments have been lagging behind in BP-I research until fairly recently 15–23 .…”

Section: Introductionmentioning

confidence: 99%

The Significance of At-Risk or Prodromal Symptoms for Bipolar I Disorder in Children and Adolescents

Hauser

Correll

2013

Can J Psychiatry

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Background While in the early identification and intervention of psychosis, specific instruments and risk criteria have been generated and validated, research into preventive strategies for bipolar-I disorder (BP-I) has only recently gained momentum. Since first signs of BP-I often start before adulthood, such efforts are especially important in the vulnerable pediatric population. Methods Narrative review of data regarding the presence and nature of potentially prodromal, i.e., sub-syndromal, symptoms prior to BP-I, defined by first-episode mania, focusing on pediatric patients. Results The possibility of early identification of youth at high-risk for BP is supported by retrospective studies of BP-I patients, and prospective studies of community samples, offspring of BP-I subjects, youth with depressive disorders, and patients at high-risk for psychosis or with BP-spectrum disorders without lifetime history of mania. These data provide essential insight into potential signs and symptoms that may enable pre-syndromal identification of BP-I in youth. However, except for offspring studies, broader prospective approaches that focus on youth at risk for BP-I and on developing specific interviews/rating scales and risk criteria are mostly missing, or in their early stage. Conclusions More work is needed to determine valid clinical high-risk criteria, to distinguish risk factors, endophenotypes and comorbidities from specific prodromal symptomatology, and to develop phase-specific interventions that titrate the risk of intervention to the risk of transition to mania and to functional impairment or distress. Moreover, studies are needed that determine potential differences in prodromal symptoms and trajectories between children, adolescents and adults, and the best phase-specific interventions.

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Risk constellations prior to the development of bipolar disorders: Rationale of a new risk assessment tool

Cited by 94 publications

References 91 publications

Dissociative experiences in bipolar disorder II: Are they related to childhood trauma and obsessive-compulsive symptoms?

Dissociative experiences in bipolar disorder II: Are they related to childhood trauma and obsessive-compulsive symptoms?

Screening for bipolar disorders: A public health issue

The Significance of At-Risk or Prodromal Symptoms for Bipolar I Disorder in Children and Adolescents

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