Risk behaviour among blood donors who give blood in order to be tested for the human immunodeficiency virus

Stigum, Hein; Bosnes, Vidar; Popp, Magnus; Orjasaeter, H

doi:10.1046/j.1423-0410.2001.00006.x

Cited by 29 publications

(40 citation statements)

References 1 publication

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“…The estimated number of Y alleles gave concordant results with the number of males reported by two surveys of people donating blood to the Oslo blood bank in 1998 and 2000 [9,10], the same year these samples were collected ( Table 1). …”

Section: Discussionsupporting

confidence: 78%

High‐throughput gender determination using automated denaturant gel capillary electrophoresis

Hinselwood¹,

Warren

Ekstrøm³

2005

Electrophoresis

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Sex determination of anonymous samples is a requirement before analysis of DNA variation on X or Y chromosomes. Based on this, we designed a method for screening samples on different DNA capillary sequencing instruments with a sensitivity that is able to quantify sex chromosome abnormalities. The two different amelogenin alleles sited on the X and Y chromosomes were polymerase chain reaction amplified with the same set of primers and separated by denaturant capillary electrophoresis (DCE). Sex chromosome ratios could be reproducibly determined with a relative standard deviation of 8.7%, which is sufficient to distinguish a normal XY karyotype from an XYY karyotype associated with Klinefelter syndrome. Reconstruction experiments demonstrated sensitivity down to a simulated Y:X allelic ratio of 1:127 in all three instruments, enabling the prediction of sex chromosomal aneuploidies. When tested on anonymous pooled and single samples, DCE gave a good prediction of the male to female ratio in pools of 1000 blood donors. In conclusion, DCE is a simple and robust method for sex determination that can be readily performed on commercially available CE systems.

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Section: Discussionsupporting

confidence: 78%

High‐throughput gender determination using automated denaturant gel capillary electrophoresis

Hinselwood¹,

Warren

Ekstrøm³

2005

Electrophoresis

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“…The main underlying reason for this problem is that testing for HIV is free of charge and fast at blood centers and people wish to avoid the social stigmatization of specifically being tested for HIV. 3,4 Confidential self-exclusion (CSE) systems have been designed for this type of blood donor, so that high-risk donors can confidentially exclude their blood from use for transfusions. 1 The first CSE system was designed in 1984 in the United States as an option for improving blood safety, 1 and similar systems have since been used in many countries.…”

Section: Introductionmentioning

confidence: 99%

Positivity of HIV, hepatitis B and hepatitis C in patients enrolled in a confidential self-exclusion system of blood donation: a cross-sectional analytical study

Kasraian

Tavasoli

2010

Sao Paulo Med. J.

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Positivity of HIV, hepatitis B and hepatitis C in patients enrolled in a confidential self-exclusion system of blood donation: a cross-sectional analytical study METHODS:The results from the abovementioned tests were compared between donors who opted into and out of CSE.RESULTS: 100,148 donors in 2006 and 104,271 in 2007 gave blood. Among these donors, respectively, 829 (0.82%) and 592 (0.57%) opted for the CSE. The prevalence of HIV antibodies, HBS antigens and HCV antibodies in CSE donors was significantly higher than in donors who did not choose CSE (P < 0.05). The prevalence of at least one of these three infections among CSE donors was 3.12% in 2006 and 3.04% in 2007, and was significantly higher than the prevalence among non-CSE donors (0.58% and 0.57%, respectively). CONCLUSION:Because of the higher prevalence of HBS, HCV and HIV positivity in blood donors who chose the CSE option, offering CSE to blood donors could be a potentially useful method for improving blood safety, since it could increase the detection of infected blood during the window period.

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“…Epidemiological data of the blood donor population can add to transfusion safety because it facilitates analysis of risk fac-30], but investigations in Norway found that HIV test seekers did not have particulars risks for acquiring an HIV infection [31]. In our study all HIV-positive donors between 2001 and 2005 and matched controls were questioned anonymously about donor motivation, knowledge about donation and infectious diseases and personal risk factors.…”

Section: Resultsmentioning

confidence: 97%

Epidemiological Data – an Important Part of the Hemovigilance System

Offergeld

Hamouda²,

Bürger³

2010

Transfus Med Hemother

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Epidemiological data are essential for monitoring trends and outbreaks of infectious diseases in the general population. The reporting system pursuant to the Infection Protection Act in Germany results in a very good quality of timely nationwide data on all reportable diseases including those relevant for the blood supply: HIV, hepatitis C, hepatitis B and syphilis. Notifications of acute hepatitis B and first-time diagnosed hepatitis C infections in the general population showed a declining trend in the past years, but the number of reports of HIV and syphilis infections increased until 2007 especially among men who have sex with men. New preventive strategies should also address changes in sexual behavior. The specific surveillance of blood donors is an important part of the hemovigilance system. The highly effective donor selection process results in a small number of confirmed infections among donors in Germany. The surveillance data enable us to identify specific trends that might challenge blood safety like the increase in HIV infections among repeat donors. Specific evaluations are performed when needed. These additional studies can be used to modify guidelines or recommendations and to (re)evaluate the need for or the effect of further testing.

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Risk behaviour among blood donors who give blood in order to be tested for the human immunodeficiency virus

Abstract: The proportion who donated blood in order to be HIV tested was higher than expected, but the majority of the group did not have any identifiable HIV risk.

Cited by 29 publications

References 1 publication

High‐throughput gender determination using automated denaturant gel capillary electrophoresis

High‐throughput gender determination using automated denaturant gel capillary electrophoresis

Positivity of HIV, hepatitis B and hepatitis C in patients enrolled in a confidential self-exclusion system of blood donation: a cross-sectional analytical study

Epidemiological Data – an Important Part of the Hemovigilance System

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