Risk-based Stratification of Salivary Gland Lesions on Cytology: An Institutional Experience

Abstract

FNAC; Salivary Gland Lesions; Risk-based Stratification; Milan SystemBackground & objective: Fine needle aspiration cytology (FNAC) of salivary gland lesions is an accepted and useful diagnostic tool to differentiate between benign and malignant lesions. Majority of the neoplasms are benign, and specific diagnosis on cytology can be made in most of the cases. However, the utility is limited by the overlapping and heterogeneous morphological features of benign and malignant neoplasms. The current study aimed at investigating the cytomorphological features of salivary gland lesions with histopathological correlation and performing risk based stratification of these lesions using the recommended Milan system for reporting of salivary gland cytopathology (MSRSGC).Methods: The current study was conducted on 192 retrospective and prospective cases of salivary gland lesions over a period of three years from October 2014 to September 2017. Cytohistopathological correlation was observed in 62 cases. Subsequently,cytomorphological features were further revaluated, classified according to MSRSGC into six groups, and correlated with clinico-histopathological features.Results: Diagnostic sensitivity and specificity of FNAC for salivary gland lesions was 63.16% and 97.62%, respectively. The positive predictive value was 92.31% and negative predictive value was 85.42%. The diagnostic accuracy to differentiate between benign and malignant lesions was 86.88%.The number of cases in each diagnostic category and the risk of malignancy (ROM) were as follows: nondiagnostic -three cases (ROM -33.33%), nonneoplastic -14 cases (ROM -7.14%), atypical -one case (ROM -100%), benign -28 cases (ROM -7.14%), NUMP -one case (ROM -100%), suspicious -one case (ROM -100%), and malignant -13cases (ROM -92.30%).Conclusion: Risk based stratification scheme as recommended by MSRSGC can provide a standard method to analyse the results and help to plan the management of salivary gland lesions.

Cytopathological study of salivary gland lesions in rural population: Use of the Milan system for reporting

“…In the category IV/ Neoplastic: B: SUMP, two cases i.e. 2(1.33%) [ Fig: 3D] with high cellularity and or atypia with suspicious of malignant potential were included which was comparable to previous study done by Jaiswal P et al [7].…”

Salivary Gland FNA Diagnostics in a Real-Life Setting: One-Year-Experiences of the Implementation of the Milan System in a Tertiary Care Center

“…Among all FNAs with histological follow-up, 22 out of 90 cases (24.4%) were non-neoplastic lesions, whereas 68 lesions (75.6%) were neoplastic and 16 lesions (17.8%) were malignant. The risk of neoplasm, the risk of malignancy, and the overall risk of malignancy were calculated for each MSRSGC category (Table 3) and compared with other MSRSGC studies [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26] and MSRSGC estimated ROMs (Table 4).…”

The Milan system for reporting salivary gland cytopathology: A comprehensive review of the literature

“…In addition, the uniform terminology allows cross communication between pathologists and institutions. Since the print publication of the MSRSGC in 2018, many institutions across the world retrospectively applied this tired diagnostic scheme to their institutional cohort of cases or those collected from multiple institutions and reported their findings with and without surgical follow‐up 6‐43 …”