Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease

Stojsavljević, Aleksandar; Rovčanin, Branislav; Krstić, Đurđa; Borković-Mitić, Slavica; Paunović, Ivan; Diklić, Aleksandar; Gavrović-Jankulović, Marija; Manojlović, Dragan

doi:10.1007/s12403-019-00309-9

Cited by 37 publications

(38 citation statements)

References 33 publications

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“…Comparison of values obtained for Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn contents in the NT and HT samples with median of means reported by other researches [9,[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68] depicts in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Zaichick¹

2021

World J. Adv. Res. Rev.

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Role of trace elements (TE) in etiology and pathogenesis of Hashimoto's thyroiditis (HT) is unclear. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of ten TE (Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn) are present in the autoimmune transformed thyroid. Ten TE of thyroid tissue were determined in 8 patients with HT and 105 healthy populations. The measurements were performed using non-destructive instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides. Elevated mean values of Ag, Hg, and Rb content were found in thyroid with HT in comparison with normal level (in approximately 21, 30, and 1.6 times, respectively). Because the considerable changes in some TE contents in tissue of thyroid with HT were found, it is reasonable to assume that the levels of these TE in thyroid tissue can be used as HT markers. However, this topic needs additional studies.

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Section: Resultsmentioning

confidence: 99%

Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Zaichick¹

2021

World J. Adv. Res. Rev.

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“…These data are in good agreement with our results. The completely opposite results were demonstrated by Błazewicz et al [81] and Stojsavljević et al [63]. They found that the content of Cu was reduced in NG.…”

Section: Coppermentioning

confidence: 86%

Determination of twenty chemical element contents in normal and goitrous thyroid using X-ray fluorescent and neutron activation analysis

Zaichick¹

2021

World J. Adv. Res. Rev.

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Nodular goiter (NG) is an internationally important health problem. The aim of this exploratory study was to examine the content of silver (Ag), bromine (Br), calcium (Ca), chlorine (Cl), cobalt (Co), chromium (Cr), cooper (Cu), iron (Fe), mercury (Hg), iodine (I), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), rubidium (Rb), ammonium (Sb), scandium (Sc), selenium (Se), strontium (Sr), and zinc (Zn) in the normal thyroid and in the thyroid tissues with diagnosed colloid NG.. Thyroid tissue levels of twenty chemical elements (ChE) were prospectively evaluated in 46 patients with NG and 105 healthy inhabitants. Measurements were performed using non-destructive energy-dispersive X-Ray fluorescent analysis combined with instrumental neutron activation analysis with high resolution spectrometry of short– and long-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for ChE analysis. It was found that during a goitrous transformation the levels of Ag, Br, Cl, Co, Cu, Fe, Hg, Mg, Na, and Sc in thyroid tissue significantly increased, whereas the levels of I and Sr decrease. It was supposed that the changes in levels Ag, Br, Cl, Co, Cu, Fe, Hg, I, Mg, Na, Sc, and Sr in thyroid tissue can be used as NG markers.

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“…According to that study 5 , the reduced contents of Zn in liquid clinical samples and increased content in CTs could indicate the potential of malignant brain cells to withdraw essential Zn from the blood and/or CSF into the CT for the stimulation of cerebral tissue growth. Considering that the Cu/Zn ratio has been recommended as a suitable diagnostic blood marker for a great number of diseases, including various cancers 23 , we wanted to examine its potential role in the diagnostics of MBTs. The results of this research showed the Cu/Zn ratio has no role in discriminating our MBT samples from control samples, an important finding for excluding the Cu/Zn ratio from further evaluation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

Stojsavljević

Vujotić

Rovčanin

et al. 2020

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The pathogenesis of malignant brain tumors (MBTs) should be better understood due to the evident association between prolonged exposure to metals and increased risk of MBTs. The present research aimed to find trace metals that could contribute to the pathogenesis of MBTs. Essential trace elements (Mn, Co, Zn, Cu, Se) and relevant toxic metals (Al, Ni, As, Sr, Cd, Ce, Pt, Pb, U) in the serum, cell fraction (CF), cerebrospinal fluid (CSF) and cancerous tissue (CT) samples of MBT patients were analyzed. The results were compared with sex-and age-matched control groups. For the first time, this research showed that elemental profiles of serum, CF, CSF and CT samples in MBT patients were significantly altered compared to the appropriate controls, as well as that higher contents of trace elements (particularly Mn, Se, and Pb) could be involved in the pathogenesis of MBTs. However, the most noticeable change found was the elevated U content, indicating its considerable role as a major cerebral discriminator of the presence/absence of MBTs. The U/Se ratio could be considered as an appropriate blood marker in diagnostic MBT evaluation. The reported results could contribute to better understanding of the poorly understood pathogenesis of MBTs. Furthermore, the reported results could highlight a molecular basis for the pathophysiological changes caused by the hazardous effects of trace metals on brain homeostasis. The importance of trace metals in the neurosciences has become more compelling during the first decade of the 21 st century 1 , as there is considerable interest in finding the relationships between trace metals and various neurological diseases, including central nervous system (CNS) malignancies. Metals show their harmful effects at the first stage of cancerogenesis (initiation) 2. Initiation can affect normal biochemical reactions, leading to alterations in metal profiles. Considering that trace metals play a significant role in neoplastic processes, the metal contents in neoplastic samples can differ from the composition in control ones 3. Homeostasis of metals within tight physiological limits is maintained through the mechanisms of uptake, distribution, accumulation, and secretion. Each breakdown has deleterious effects on metal-regulated metabolic pathways and can be a crucial step in the pathogenesis of various diseases. The most important pathway in metal-induced cancerogenesis is the ability of a metal to modulate gene expression by interfering with signal transduction pathways, leading to the deregulation of cell proliferation, activation of numerous transcription factors, disruption of cell cycle course, and apoptosis 4. Metal homeostasis is critical for the proper functioning of the brain 5. The brain is a target organ for toxic environmental pollutants 6. The balance of metals within the brain is regulated through the blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) barrier. In physiological conditions, these barriers regulate CNS homeostasis

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Risk Assessment of Toxic and Essential Trace Metals on the Thyroid Health at the Tissue Level: The Significance of Lead and Selenium for Colloid Goiter Disease

Cited by 37 publications

References 33 publications

Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Comparison of trace element contents in normal thyroid and thyroid with Hashimoto's thyroiditis using neutron activation analysis

Determination of twenty chemical element contents in normal and goitrous thyroid using X-ray fluorescent and neutron activation analysis

Assessment of trace metal alterations in the blood, cerebrospinal fluid and tissue samples of patients with malignant brain tumors

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