Risk assessment of the impact on human health of resistant Campylobacter jejuni from fluoroquinolone use in beef cattle

Anderson, Steven A.; Woo, R.W Yeaton; Crawford, Lester M.

doi:10.1016/s0956-7135(00)00014-1

Cited by 50 publications

(34 citation statements)

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“…A few investigators have undertaken the challenging task of developing mathematical models in order to predict the impacts of NTAs on human disease (12,19,20,46,91,99,134,135). Models can be very useful in attempting to define the types of diverse data sets that are seen in this field.…”

Section: Addressing Knowledge Gaps: Reservoirs Of Antibiotic Resistancementioning

confidence: 99%

Food Animals and Antimicrobials: Impacts on Human Health

2011

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SUMMARY Antimicrobials are valuable therapeutics whose efficacy is seriously compromised by the emergence and spread of antimicrobial resistance. The provision of antibiotics to food animals encompasses a wide variety of nontherapeutic purposes that include growth promotion. The concern over resistance emergence and spread to people by nontherapeutic use of antimicrobials has led to conflicted practices and opinions. Considerable evidence supported the removal of nontherapeutic antimicrobials (NTAs) in Europe, based on the “precautionary principle.” Still, concrete scientific evidence of the favorable versus unfavorable consequences of NTAs is not clear to all stakeholders. Substantial data show elevated antibiotic resistance in bacteria associated with animals fed NTAs and their food products. This resistance spreads to other animals and humans—directly by contact and indirectly via the food chain, water, air, and manured and sludge-fertilized soils. Modern genetic techniques are making advances in deciphering the ecological impact of NTAs, but modeling efforts are thwarted by deficits in key knowledge of microbial and antibiotic loads at each stage of the transmission chain. Still, the substantial and expanding volume of evidence reporting animal-to-human spread of resistant bacteria, including that arising from use of NTAs, supports eliminating NTA use in order to reduce the growing environmental load of resistance genes.

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Section: Addressing Knowledge Gaps: Reservoirs Of Antibiotic Resistancementioning

confidence: 99%

Food Animals and Antimicrobials: Impacts on Human Health

2011

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“…Consumption of contaminated foods is also a source of resistant bacteria: it has been estimated that, in the worse case scenario where prevalence of resistance Campylobacter is as high as 84%, 3-4 people per year in US will die as a result of infection with fluoroquinolone resistant Campylobacter spp. from beef consumption [6].…”

Section: Antimicrobial Resistance In Campylo-bactermentioning

confidence: 99%

<i>Campylobacter</i> <i>spp</i>. in Human, Chickens, Pigs and Their Antimicrobial Resistance

Padungton

Kaneene

2003

The Journal of Veterinary Medical Science

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ABSTRACT. Campylobacter spp. have been identified as etiologic agents in outbreaks and sporadic cases of gastroenteritis in developed countries. In developing countries, most reported Campylobacter infections are in children. Previously reported prevalences of Campylobacter spp. in children in Southeast Asia range from 2.9% to 15%. The frequency and pattern of occurrence of Campylobacter spp. differ between developed and developing countries, especially in the number of cases reported in adults and the presence of any seasonal patterns in occurrence. Although the severity of Campylobacter infection in adults was different between developed and developing countries, the clinical symptoms of infection in adults resulting from infection in developing countries was similar to those in developed countries. Many different animal species maintain Campylobacter spp. with no clinical signs. There do not appear to be significantly different colonization rates of Campylobacter in food animals between developed and developing countries. The role of C. jejuni as a primary pathogen in farm animals is uncertain. C. jejuni can be found in feces of diarrheic and healthy calves and piglets. Campylobacter with resistance to antimicrobial agents have been reported in both developed and developing countries, and the situation seems to deteriorate more rapidly in developing countries, where there is widespread and uncontrolled use of antibiotics resistance was observed at high levels in food animals in both developed and developing countries. Studies suggested an association between antimicrobial use in food animals and the development of resistance in human isolates in developed countries. KEY WORDS: antimicrobial resistance, Campylobacter spp., food animal, human.

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“…Fluoroquinolones (FQs) are synthetic antibiotics with a broad-spectrum antibacterial activity [6,7]. They were introduced for human use in Europe and the US in the mid-1980s and approved for livestock treatment in the mid-1990s [8]. Several FQs (e.g.…”

Section: Introductionmentioning

confidence: 99%