Risk assessment of premature drug release during wet granulation of ordered mesoporous silica loaded with poorly soluble compounds itraconazole, fenofibrate, naproxen, and ibuprofen

Agglomeration of Mesoporous Silica by Melt and Steam Granulation. Part II: Screening of Steam Granulation Process Variables Using a Factorial Design

“…Previous results determined that mesoporous silica had to be sufficiently moistened to form liquid bridges necessary for agglomeration. However, the material cannot be overly wetted due to the possibility of PDR . Therefore, it was hypothesized that PDR would be more prevalent in granules prepared with 180 g of steam.…”

“…It was demonstrated that the use of excess solvent during mesoporous silica processing could result in premature drug release (PDR). It is hypothesized that PDR is a result of capillary forces pulling the solvent into the pores and displacing the drug . Dry granulation is not considered because the use of pressure could result in structural damage and affect the release behavior …”

Liquisolid systems and aspects influencing their research and development

“…They were originally developed for controlled drug release formulations (67)(68)(69) and their capability to enhance the release of poorly soluble drugs was discovered later (56,70,71). In recent studies, it was observed (72, 73) that drugs lose crystallinity when deposited on the surface of mesoporous silicates, which enhances their dissolution rate.…”

Development of novel core-shell dual-mesoporous silica nanoparticles for the production of high bioavailable controlled-release fenofibrate tablets

“…A large amount of scientific research has been devoted to overcome the solubility problem of poorly water-soluble drugs involving, e.g. the use of liposomes 1,2 , polymersomes 3,4 , nanoparticles 5,6 and inorganic porous materials [7][8][9][10][11] . Compared with other methods, inorganic mesoporous materials have unique advantages as a novel solid dispersion material.…”