Risk Assessment of Oxidative Stress Induced by Metal Ions Released from Fixed Orthodontic Appliances during Treatment and Indications for Supportive Antioxidant Therapy: A Narrative Review

Primožič, Jasmina; Poljšak, Borut; Jamnik, Polona; Kovač, Viljem; Jurešić, Gordana Čanadi; Špalj, Stjepan

doi:10.3390/antiox10091359

Cited by 18 publications

(18 citation statements)

References 104 publications

(110 reference statements)

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“…Corroded appliances induce the release of metal ions, which can cause increased levels of ROS through metal-catalyzed free radical reactions. Chromium, iron, nickel, cobalt, titanium and molybdenum are a group of transition metals that can undergo redox reactions with the ROS formation [29].…”

Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of a gel composition based on a flavonoid complex for the treatment of periodontal diseases in orthodontic patients

Hodovanyi

Чухрай

Mrochko

et al. 2023

ZMJ

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The aim of the work was a preclinical assessment of acute toxicity, skin resorptive, irritant effects, cumulative and catalase activity, as well as sensitizing properties of the local gel composition “Benzidaflaziverdine” (GCB) used for the treatment of periodontal diseases in orthodontic patients. Materials and methods. 119 animals were involved in the experiment, assigned to seven main and two control groups. GCB was administered intragastrically in doses of 300–600 mg/kg and intradermally of 200 μg into the outer surface of the ear. The native solution of GCB was applied to the skin and mucous membranes, administered orally by the method of “subchronic toxicity” and to the surface of the chorioallantoic membrane (CAM) of chicken embryos. The intensity of lipid peroxidation (LPO) was assessed by the level of diene conjugates (DCs) and malondialdehyde (MDA), and the antioxidant system by catalase activity. The specific leukocyte agglomeration reaction (SLAR), the specific leukocyte lysis reaction, and neutrophil damage indicators were used. Results. The median lethal dose LD50 for rats and mice of both sexes exceeded 5000 mg/kg. The irritant effect of GCB on the mucous membranes was manifested by hyperemia on the second day. Symptoms of irritation disappeared after 3–4 days without medical intervention. An analysis of the CAM blood vessels after exposure to GCB in two observations at the 120th second showed the beginning of hemorrhages. In one observation, GCB caused minor hemorrhages at the 300th second of the experiment. It was found that the coefficient of GCB irritant action was 5 (the mean score of Me (Q1; Q3) was 5 (4; 5)). The coefficient of cumulation (Kcum) exceeded 8.2. An insignificant increase in the median or mean values of catalase enzyme activity, DCs, and the amount of LPO end product such as MDA was observed compared to the control group animals. The SLAR test indicated the development of a delayed-type allergic reaction under the influence of GCB in a 1:10 dilution. One-hundred-fold dilution did not cause significant changes in the indicator in the main group compared to the control one. Conclusions. GCB belongs to the 4th class of toxicity – practically non-toxic substances, does not have sex- and species sensitivity, has weak cumulative activity, minimal effect on the system of LPO. GCB can be recommended for the use in clinical periodontology for medical support of orthodontic patients.

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Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of a gel composition based on a flavonoid complex for the treatment of periodontal diseases in orthodontic patients

Hodovanyi

Чухрай

Mrochko

et al. 2023

ZMJ

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“…Free metal ions produced due to the wear of implants can actively undergo redox reactions and cause oxidative stress to the localized cells 34,35 . Considering this, cyclic voltammetry can further be used to establish a possible relation with the metal ion concentration based on Fenton reaction 35 .…”

Section: Cyclic Voltammetry Of Serum With Metalmentioning

confidence: 99%

“…This could be due to the various proteins dampening the particle's reactivity. Proteins such as albumin in the blood serum could interfere with the Fenton reaction involved in the oxidative stress reactions by chelation to metals 34 thereby reducing the number of redox reactions. This was further validated when the initial standardization with the particles suspended in PBS (with no presence of metal chelating proteins) revealed distinct oxidation and reduction peaks.…”

Section: Cyclic Voltammetry Of Serum With Metalmentioning

confidence: 99%

Electrochemical Biosensor to Detect Implant-Derived Metal Ions: A Mice Model

et al. 2023

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Joint replacement surgeries are progressing at an increased rate in the United States, with around 1 million surgeries being performed annually. While these orthopedic implants provide a solution for a damaged joint, debris such as metal ions generated due to the wear and corrosion of the implants prove to be of considerable risk of systemic and local toxicity. As an effective diagnostic tool, there is a need to develop a patient-friendly, cost-effective, and rapid mode of metal ion detection in orthopedic patients with various implants.In this study, an electrochemical biosensor chip (Dropsens) is proposed as a diagnostic tool to detect metal ions through changes in impedance. In vivo studies were conducted using CoCrMo particles intraparticularly injected into mice. Then, blood was collected on 0th day, 14th day, and 28th day after injection and was centrifuged to obtain serum. The serum was subject to various electrochemical techniques such as Electrochemical Impedance Spectroscopy (EIS) and cyclic voltammetry (CV). Additionally, standardization experiments were performed using different concentrations of CoCrMo wear particles suspended in PBS and mice serum.The EIS standardization experiments reveal a negative correlation between impedance (Rp) value obtained after tting with the equivalent CPE model and metal ion concentration in mice serum. A regression equation was obtained from the standard experiments. The CV data for differing metal ion concentrations and the regression equation were also obtained. The mice model data, the bode plot which depicts the change in impedance and phase angle at each frequency, the positive control group shows the highest impedance at any frequency followed by the experimental 28th day mice serum. The % change in impedance between the different groups revealed the increasing presence of metal ions in serum on 28th day. The CV experimental data obtained reveal a possible correlation between CV area and metal ion concentrations. Experimental mice models were established to mimic the possible diffusion of metal particles from implants. Dropsens electrochemical biosensors were e ciently employed to detect metal ions in serum through changes in impedance.

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Section: Cyclic Voltammetry Of Serum With Metalmentioning

confidence: 99%

Electrochemical Biosensor to Detect Implant Derived Metal Ions: A Mice Model

Gokul

Catton

Cheng

et al. 2022

Preprint

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Joint replacement surgeries are progressing at an increased rate in the United States, with around 1 million surgeries being performed annually. While these orthopedic implants provide a solution for a damaged joint, debris such as metal ions generated due to the wear and corrosion of the implants prove to be of considerable risk of systemic and local toxicity. As an effective diagnostic tool, there is a need to develop a patient-friendly, cost-effective, and rapid mode of metal ion detection in orthopedic patients with various implants. In this study, an electrochemical biosensor chip (Dropsens) is proposed as a diagnostic tool to detect metal ions through changes in impedance. In vivo studies were conducted using CoCrMo particles intra-particularly injected into mice. Then, blood was collected on 0th day, 14th day, and 28th day after injection and was centrifuged to obtain serum. The serum was subject to various electrochemical techniques such as Electrochemical Impedance Spectroscopy (EIS) and cyclic voltammetry (CV). Additionally, standardization experiments were performed using different concentrations of CoCrMo wear particles suspended in PBS and mice serum. The EIS standardization experiments reveal a negative correlation between impedance (Rp) value obtained after fitting with the equivalent CPE model and metal ion concentration in mice serum. A regression equation was obtained from the standard experiments. The CV data for differing metal ion concentrations and the regression equation were also obtained. The mice model data, the bode plot which depicts the change in impedance and phase angle at each frequency, the positive control group shows the highest impedance at any frequency followed by the experimental 28th day mice serum. The % change in impedance between the different groups revealed the increasing presence of metal ions in serum on 28th day. The CV experimental data obtained reveal a possible correlation between CV area and metal ion concentrations. Experimental mice models were established to mimic the possible diffusion of metal particles from implants. Dropsens electrochemical biosensors were efficiently employed to detect metal ions in serum through changes in impedance.

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Risk Assessment of Oxidative Stress Induced by Metal Ions Released from Fixed Orthodontic Appliances during Treatment and Indications for Supportive Antioxidant Therapy: A Narrative Review

Cited by 18 publications

References 104 publications

Preclinical evaluation of a gel composition based on a flavonoid complex for the treatment of periodontal diseases in orthodontic patients

Preclinical evaluation of a gel composition based on a flavonoid complex for the treatment of periodontal diseases in orthodontic patients

Electrochemical Biosensor to Detect Implant-Derived Metal Ions: A Mice Model

Electrochemical Biosensor to Detect Implant Derived Metal Ions: A Mice Model

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