Risk assessment of oral leukoplakia malignant transformation based on the ubiquitin-proteasome system indicators
D. E. Mikhalev,
O. D. Baydik,
I. V. Kondakova
et al.
Abstract:Relevance. The ubiquitin-proteasome system controls the activity and stability of various cellular proteins that affect cellular homeostasis by the regulation of signalling cascades. The system activity is associated with the onset and progression of oral squamous cell carcinoma, as the system participates in the specific proteolysis of most intracellular proteins involved in cancer pathogenesis.Material and methods. The study included 61 patients (28 men and 33 women) aged 21 to 75 y.o. The study determined c… Show more
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