Risk Assessment of Neonatal Exposure to Low Frequency Noise Based on Balance in Mice

Ohgami, Nobutaka; Oshino, Reina; Ninomiya, H.; Li, Xiang; Kato, Masashi; Yajima, Ichiro

doi:10.3389/fnbeh.2017.00030

Cited by 13 publications

(13 citation statements)

References 24 publications

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“…This is quite problematic since many studies affirm that most of the time, there are elevated low frequency intensities in NICUs (3, 32) caused by electronic devices (46). Although the information is limited, some studies suggest that low frequency exposure may have negative effects on neonates, as is the case for animals with auditory thresholds higher than those of humans (35).…”

Section: Discussionmentioning

confidence: 99%

“…However, there is limited information on the specific effects caused by the low frequencies to which neonates are exposed. In that regard, a recent study suggested that if low frequency exposures have negative impacts on the health of exposed mice, which have a higher threshold for low frequencies than that for humans [375 (34) and 20 Hz, respectively], they could also have negative impacts on humans (35). Results show that the exposure of mice to low frequency noise with levels of 70 dB over 4 weeks causes permanent imbalance and a reduction of the number of calbindin-positive hair cells in the saccule and utricle (35).…”

Section: Introductionmentioning

confidence: 99%

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Influence of the NICU on the Acoustic Isolation of a Neonatal Incubator

et al. 2020

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The neonatal intensive care unit (NICU) is a very noisy place as compared to the intrauterine environment. To protect the neonate's health, international guidelines suggest avoiding noise levels above 45 dB in NICUs, but this recommendation is not normally met. The incubator acoustic isolation and the acoustic features of the NICU play important roles in determining the noise measured inside the incubator. In this study, the influence of two types of rooms, one with sound-absorbent covering and the other with reverberant surfaces, on the acoustic isolation of a neonatal incubator was evaluated using three acoustic isolation indexes: the level difference, the apparent sound reduction index, and the standardized level difference. Results show that the acoustic isolation of the incubator is very poor, with a level difference below 11 dBA at all frequencies. At 62.5 Hz, the level difference measured in both rooms exhibits a negative value, indicating that the incubator amplifies the noise coming from the NICU. Isolation of the incubator is poor, and the reverberation time (RT) of the containing room influences RT of the incubator, which is consequently higher when the containing room is reverberant; for example, the incubator RT in the reverberant NICU is 0.72 s higher at 500 Hz than that in a room with sound-absorbent covering.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of the NICU on the Acoustic Isolation of a Neonatal Incubator

et al. 2020

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“…A previous study showed that galvanic vestibular stimulation (GVS) delivered as imperceptible white noise only at an intensity of 270 mA for healthy subjects or 450 mA for patients with bilateral vestibular dysfunction resulted in improvement of balance 28 . Our experimental studies have shown that constitutive exposure to sound with a peak of 100 Hz, 70 dB for 1 month caused impairment of the vestibule in mice 29 , 30 . Therefore, it is possible that the target organ for the sound component at 100 Hz in music is the vestibule.…”

Section: Discussionmentioning

confidence: 70%

Improvement of balance in young adults by a sound component at 100 Hz in music

Ohgami

et al. 2018

Sci Rep

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About 80% of young people use personal listening devices (PLDs) including MP3 players to listen to music, which consists of sound components with various frequencies. Previous studies showed that exposure to noise of high intensities affected balance in humans. However, there is no information about a frequency-dependent effect of sound components in music from a PLD on balance in young people. In this study, we determined the associations between sound component levels (dB) at 100, 1000 and 4000 Hz in music from a portable listening device (PLD) and balance objectively determined by posturography in young adults (n = 110). We divided the subjects into two groups (low and high exposure groups) based on cut-off values of sound component levels at each frequency using receiver operating characteristic (ROC) curves. Balance in the high exposure group (≥46.6 dB) at 100 Hz was significantly better than that in low exposure group in logistic regression models adjusted for sex, BMI, smoking status and alcohol intake, while there were no significant associations at 1000 and 4000 Hz. Thus, this study demonstrated for the first time that the sound component at 100 Hz with more than 46.6 dB in music improved balance in young adults.

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“…On the other hand, the rotarod test score was correlated with the amplitude of cVEMP but not with the latency of cVEMP in this study. The rotarod test has been used for determination of vestibular function [17, 19] and also other physiological functions including motor skill learning [40–42]. Therefore, it is unlikely that cVEMP latency is associated with physiological functions other than the vestibular systems.…”

Section: Discussionmentioning

confidence: 99%

“…The method reported previously was used for the rotarod test [19]. Mice (4 weeks of age) were placed on a stable rod of 5.7 cm in diameter (47600-Mouse Rota-Rod, UGO BASILE, Italy), and then the rod was rotated at a constant speed of 10 rpm/min for 10–20 s as training.…”

Section: Methodsmentioning

confidence: 99%

cVEMP correlated with imbalance in a mouse model of vestibular disorder

Negishi-Oshino

Ohgami

et al. 2019

Environ Health Prev Med

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Background Cervical vestibular evoked myogenic potential (cVEMP) testing is a strong tool that enables objective determination of balance functions in humans. However, it remains unknown whether cVEMP correctly expresses vestibular disorder in mice. Objective In this study, correlations of cVEMP with scores for balance-related behavior tests including rotarod, beam, and air-righting reflex tests were determined in ICR mice with vestibular disorder induced by 3,3′-iminodipropiontrile (IDPN) as a mouse model of vestibular disorder. Methods Male ICR mice at 4 weeks of age were orally administered IDPN in saline (28 mmol/kg body weight) once. Rotarod, beam crossing, and air-righting reflex tests were performed before and 3–4 days after oral exposure one time to IDPN to determine balance functions. The saccule and utricles were labeled with fluorescein phalloidin. cVEMP measurements were performed for mice in the control and IDPN groups. Finally, the correlations between the scores of behavior tests and the amplitude or latency of cVEMP were determined with Spearman’s rank correlation coefficient. Two-tailed Student’s t test and Welch’s t test were used to determine a significant difference between the two groups. A difference with p < 0.05 was considered to indicate statistical significance. Results After oral administration of IDPN at 28 mmol/kg, scores of the rotarod, beam, and air-righting reflex tests in the IDPN group were significantly lower than those in the control group. The numbers of hair cells in the saccule, utricle, and cupula were decreased in the IDPN group. cVEMP in the IDPN group was significantly decreased in amplitude and increased in latency compared to those in the control group. cVEMP amplitude had significant correlations with the numbers of hair cells as well as scores for all of the behavior tests in mice. Conclusions This study demonstrated impaired cVEMP and correlations of cVEMP with imbalance determined by behavior tests in a mouse model of vestibular disorder. Electronic supplementary material The online version of this article (10.1186/s12199-019-0794-8) contains supplementary material, which is available to authorized users.

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Risk Assessment of Neonatal Exposure to Low Frequency Noise Based on Balance in Mice

Cited by 13 publications

References 24 publications

Influence of the NICU on the Acoustic Isolation of a Neonatal Incubator

Influence of the NICU on the Acoustic Isolation of a Neonatal Incubator

Improvement of balance in young adults by a sound component at 100 Hz in music

cVEMP correlated with imbalance in a mouse model of vestibular disorder

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