Risk Assessment of Lung Cancer and Asbestosis in Workers Exposed to Asbestos Fibers in Brake Shoe Factory in Iran

Azari, Mansour Rezazadeh; Nasermoaddeli, Ali; Movahadi, Mohammad; Mehrabi, Yadollah; Hatami, Hossein; Soori, Hamid; Moshfegh, Elaheh; Ramazni, Behnam

doi:10.2486/indhealth.48.38

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Although asbestos has been banned in many Western countries, it is still used in several parts of the world, and some developing countries are actually increasing the industrial use of asbestos, as well as its production and importation [5], [6], [7]. In Western Europe, over 5,000 people with MPM die each year [8], [9], [10], [11].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

et al. 2013

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Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, only 5–17% of those exposed to asbestos develop MPM, suggesting the involvement of other environmental and genetic risk factors.To identify the genetic risk factors that may contribute to the development of MPM, we conducted a genome-wide association study (GWAS; 370,000 genotyped SNPs, 5 million imputed SNPs) in Italy, among 407 MPM cases and 389 controls with a complete history of asbestos exposure. A replication study was also undertaken and included 428 MPM cases and 1269 controls from Australia.Although no single marker reached the genome-wide significance threshold, several associations were supported by haplotype-, chromosomal region-, gene- and gene-ontology process-based analyses. Most of these SNPs were located in regions reported to harbor aberrant alterations in mesothelioma (SLC7A14, THRB, CEBP350, ADAMTS2, ETV1, PVT1 and MMP14 genes), causing at most a 2–3-fold increase in MPM risk. The Australian replication study showed significant associations in five of these chromosomal regions (3q26.2, 4q32.1, 7p22.2, 14q11.2, 15q14).Multivariate analysis suggested an independent contribution of 10 genetic variants, with an Area Under the ROC Curve (AUC) of 0.76 when only exposure and covariates were included in the model, and of 0.86 when the genetic component was also included, with a substantial increase of asbestos exposure risk estimation (odds ratio, OR: 45.28, 95% confidence interval, CI: 21.52–95.28).These results showed that genetic risk factors may play an additional role in the development of MPM, and that these should be taken into account to better estimate individual MPM risk in individuals who have been exposed to asbestos.

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Section: Introductionmentioning

confidence: 99%

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

et al. 2013

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“…High mean concentration of MgO and SiO 2 , were 13.6% and 47.5% in comparison with a control sample Table (2), confirms presence asbestos in the dust samples, because all types of asbestos products contains MgO and SiO 2 (Zussman, 1979;Sergeev & Goncharov, 1990 Our questionnaires that included the data about the buildings from which the samples were taken and the health condition of their inhabitants showed that the age of those buildings built by the British authorities during the British occupation of Aden is from 60-150 years ago and all the buildings designed similarly.…”

Section: Resultsmentioning

confidence: 88%

“…; Kazan-Allen, 2005;Azari, et al, 2010;Craighead, 2011). The diseases can take many years (15-60) to develop.…”

mentioning

confidence: 99%

تقدير تركيز العناصر والأكاسيد في غبار أسقف الأسبستوس المستخدمة في منازل بلدة القلوعة، اليمن

Salem¹,

Saeed²

2020

Journal of Natural Sciences, Life and Applied Sciences

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In this research we evaluated elements and oxides concentration of corrugated asbestos cement used in the roofs of houses in Al-Qalluah area- Aden city, Yemen in the period from August to September 2018. In Aden city, many houses were built between 1880 and 1990 and therefore corrugated asbestos cement roofs as one type of asbestos boards, were used widely in coverage of the buildings and garages. Airborne asbestos fibers may remain suspended in the air for some time and can be carried long distances by wind before settling down. The risk of developing asbestos-related diseases, like lung cancer, is associated with the level and duration of exposure. All the dust samples collected from different sites in Al-Qalluah area were sent to the National Research Center- Cairo and analyzed by QUANTA FEG 250 polarized-light microscopy (PLM), using the EPA 600/R-93/116 method. The overall results of scanning PLM for dust samples have shown fibers of asbestos with diameter ranged between 2.634-22.49μm. PLM quantitative analysis coupled with EDAX TEAM have found the mean concentrations 39, 36.5, 19.2, 31.8, 36.7 and 28.4 wt/wt% with respect to C, O, Mg, Al, Si, and Ca, while the mean concentrations of oxides CO2, MgO, Al2O3, SiO2, CaO, SO3, Fe2O3, K2O and Cl2O, were 46.4, 13.6, 34.8, 47.5, 29.0, 29.1, 31.5, 32.0 and 43.8 wt/wt% respectively. Asbestos boards should be encapsulated by a safe material to prevent or reduce their risks and the authorities should stop asbestos impacts on the environment and human health.

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“…Um aumento no risco de morte por câncer de pulmão foi observado em um estudo do tipo coorte realizado nos EUA com trabalhadores da indústria de sapatos expostos a solventes como o tolueno 39 . Câncer de pulmão também tem sido associado com a exposição ao asbesto em trabalhadores da indústria de pastilha de freio 40 e na fabricação de cimento amianto e tecelagem de tecidos 41,42 . Um estudo do tipo coorte realizado nos EUA com trabalhadores aeroespaciais encontrou um risco aumentado no desenvolvimento de câncer de pulmão quando expostos a óleos minerais 43 .…”

Section: Câncer De Pulmão E Mesoteliomaunclassified

Câncer relacionado ao trabalho: uma revisão sistemática

2013

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Cad. Saúde Colet., 2013, Rio de Janeiro, 21 (2): 209-23 209 RevisãoResumo A exposição a substâncias carcinogênicas é reconhecidamente maior nos ambientes de trabalho, e muitas destas foram assim classificadas a partir de estudos epidemiológicos realizados com populações trabalhadoras. O objetivo do estudo foi realizar uma revisão integrativa sobre os principais agentes carcinogênicos presentes no ambiente de trabalho, bem como as principais topografias acometidas por estas substâncias. Foi realizado levantamento nas bases de dados LILACS e MEDLI-NE, cujo termo de busca foi "occupational cancer" e "câncer ocupacional". Observou-se que os artigos apontam para o fato de ser provável que a exposição ambiental/ocupacional à agentes químicos de uma forma geral esteja contribuindo também para o adoecimento da população, sem que uma relação entre causa e efeito seja estabelecida. A difusão de substâncias químicas não ocorre exclusivamente através das conhecidas formas de poluição. Portanto, é de fundamental importância a construção de um sistema de vigilância destes agravos que cumpra dois objetivos principais: a identificação e controle de ambientes de trabalho onde existe potencial exposição à agentes carcinogênicos e a sistematização de informações necessárias à realização de estudos epidemiológicos de caráter exploratório ou analítico.Palavras-chave: câncer; saúde do trabalhador; saúde pública. AbstractExposure to carcinogenic substances is known in most work environments, and many of these were classified as from epidemiological studies on working populations. The objective of this study is an integrative review on the main carcinogens at work environment as well as the main topographies affected by these substances. Survey was conducted in the databases MEDLINE and LILACS, whose term has been "câncer ocupacional" and "occupational cancer". It was observed that the articles point to the fact that it is likely that exposure to environmental/occupational to chemicals in general is also contribute to the disease population, without any relationship between cause and effect is established. The diffusion of chemicals does not occur exclusively through the known forms of pollution. It is therefore of paramount importance to build a surveillance system that meets these injuries two main objectives: to identify and control work environments where there is potential exposure to carcinogenic agents and systematization of information necessary to conduct epidemiological studies, whether exploratory or analytical.

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Risk Assessment of Lung Cancer and Asbestosis in Workers Exposed to Asbestos Fibers in Brake Shoe Factory in Iran

Cited by 9 publications

References 16 publications

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

Genetic Variants Associated with Increased Risk of Malignant Pleural Mesothelioma: A Genome-Wide Association Study

تقدير تركيز العناصر والأكاسيد في غبار أسقف الأسبستوس المستخدمة في منازل بلدة القلوعة، اليمن

Câncer relacionado ao trabalho: uma revisão sistemática

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