Risk assessment of exposure to aflatoxin B1 and ochratoxin A through consumption of different Pistachio ( Pistacia vera L.) cultivars collected from four geographical regions of Iran

Taghizadeh, Seyedeh Faezeh; Rezaee, Ramin; Davarynejad, Gholam Hossein; Asili, Javad; Nemati, Seyed Hossein; Γούμενου, Μαρίνα; Tsakiris, Ioannis; Tsatsakis, Aristidis; Shirani, Kobra; Karimi, Gholamreza

doi:10.1016/j.etap.2018.05.010

Cited by 60 publications

(42 citation statements)

References 62 publications

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“…Chemical and natural toxins influence the liver, which is a vital metabolic organ for drug and xenobiotic metabolism [1,2]. One of the most prevalent causes of end-stage liver disease that leads to hepatocellular carcinoma is infection with the Hepatitis C Virus (HCV).…”

Section: Introductionmentioning

confidence: 99%

Contrasting Role of Dose Increase in Modulating Sofosbuvir-Induced Hepatocyte Toxicity

2020

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Sofosbuvir, the oral direct-acting antiviral, is a medication, which used as the effective treatment for hepatitis C infection. Although sofosbuvir thought to have few adverse-effects, there have been some experiences of serious drug-induced hepatotoxicity. In this research, the molecular/cellular pathways that lead to sofosbuvir-induced hepatotoxicity were evaluated on isolated rat hepatocytes. Rat hepatocytes were isolated using collagenase reperfusion technique. In evaluating the different pathways of sofosbuvir-induced hepatotoxicity, ROS formation, mitochondrial membrane potential collapse, lysosomal membrane damage, glutathione depletion, and the percentage of apoptosis versus necrosis were determined. Our data demonstrated that the cytotoxic effect of sofosbuvir in lower concentrations (25, 50 and 100 µM) is mediated by above stream pathways. On the other hand, sofosbuvir acts in opposite directions at higher concentrations (400 µM) and acts as an antioxidant and hepatoprotective. We concluded that sofosbuvir while looking toxic and pro-oxidant in lower concentrations, acts as protective and antioxidant in higher concentrations.

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Section: Introductionmentioning

confidence: 99%

Contrasting Role of Dose Increase in Modulating Sofosbuvir-Induced Hepatocyte Toxicity

2020

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“…Different parts of Pistacia species including leaves, kernels, hulls and gum have caught up the interest of researchers due to their biological activities such as antioxidant potential, antimicrobial and anti-inflammatory activities [10][11][12]. It has been proved that Pistacia species are rich sources of phenolic compounds including flavonols, flavanones, isoflavons, flavan-3-ols, proanthocyanidins and anthocyanin [13]. Pistachio hull is the largest by-product of pistachio industry, which is accumulated every year at harvest time and can lead to environmental pollution.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Different Parameters for the Extraction of Polyphenols and Proanthocyanidins From Pistacia Vera Hulls

Zam

2019

Int J Pharm Pharm Sci

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Objective: Pistachio (Pistacia vera L.) hull are usually discarded as waste, which can lead to environmental pollution even a significant portion of polyphenols are often present in high concentrations in the outer parts of fruits. In this way, using a pistachio hull as a source of bioactive compounds will increase the value of pistachio production and offer valorization for a useless by-product.Methods: Different ethanol concentrations (5, 10, 25, 50, 75 and 95 %) were investigated and the extraction efficiency at extraction temperature from 20 to 90 °C and extraction times from 5 to 45 min was studied. The extraction yield of total polyphenols and proanthocyanidins from the pistachio hull and the antioxidant activity of the extract were evaluated. Results:The obtained results indicated relationships between the tested parameters and extraction yield. The maximum yield for total polyphenols and proanthocyanidins was obtained with 25% ethanol at 60 °C for 15 min (13.91±0.72 and 5.86±0.45 g/100g dry weight, respectively). DPPH radical scavenging activities of extracts were proved to have a linear relationship with the polyphenols yield in the extracts (R =0.9907) with a maximum DPPH radical scavenging activity of 60.25%. Conclusion:These findings propose that pistachio hull extracts can be a valuable source of bioactive compounds.

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“…However, antioxidant properties of pistachio may vary depending on cultivation, planting area, climate and cultural practices (irrigation, fertilization etc.). Recently, studies on the biochemical substances of pistachio, it has been reported that pistachio is a good source of antioxidants and phenolic compounds (Tokusoglu et al, 2005;Arcan and Yemenicioglu, 2008;Tsantili et al, 2010;Taghizadeh et al, 2018). Limited studies are conducted of researches on sugar contents, total phenolic and antioxidant contents of the various parts of 'Uzun' pistachio cultivar to grown in GAP region.…”

Section: Introductionmentioning

confidence: 99%

Determination of Sugar, Total Phenol contents-and Antioxidant Activity of various parts ‘Uzun’ pistachio cultivar (Pistacia vera L.)

Gündeşli¹

2020

International Journal of Agriculture Environment and Food Sciences

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Risk assessment of exposure to aflatoxin B1 and ochratoxin A through consumption of different Pistachio ( Pistacia vera L.) cultivars collected from four geographical regions of Iran

Cited by 60 publications

References 62 publications

Contrasting Role of Dose Increase in Modulating Sofosbuvir-Induced Hepatocyte Toxicity

Contrasting Role of Dose Increase in Modulating Sofosbuvir-Induced Hepatocyte Toxicity

Optimization of Different Parameters for the Extraction of Polyphenols and Proanthocyanidins From Pistacia Vera Hulls

Determination of Sugar, Total Phenol contents-and Antioxidant Activity of various parts ‘Uzun’ pistachio cultivar (Pistacia vera L.)

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