Risk Assessment of Bovine Spongiform Encephalopathy Transmission Through Bone Graft Material Derived From Bovine Bone Used for Dental Applications

Sogal, A.; Tofe, AJ

doi:10.1902/jop.1999.70.9.1053

Cited by 112 publications

(70 citation statements)

References 18 publications

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“…In the case of allograft, there is some doubt as to the amount of bone formation proteins necessary for proper osteoinduction, and contagion may develop 5,6 . On the other hand, xenograft is not popular among operators because of immune rejection response by heterologous proteins, possibility of contagion, and high cost 7 . As a result, there have been many research studies on the development, application, and effect of allograft, xenograft, and synthetic graft.…”

Section: Sung-min Park Et Al: Clinical Application Of Auto-tooth Bonementioning

confidence: 99%

Clinical application of auto-tooth bone graft material

Park

Kim

et al. 2012

J Korean Assoc Oral Maxillofac Surg

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(J Korean Assoc Oral Maxillofac Surg 2012;38:2-8)Introduction: Auto-tooth bone graft material consists of 55% inorganic hydroxyapatite (HA) and 45% organic substances. Inorganic HA possesses properties of bone in terms of the combining and dissociating of calcium and phosphate. The organic substances include bone morphogenetic protein and proteins which have osteoinduction capacity, as well as the type I collagen identical to that found in alveolar bone. Auto-tooth bone graft material is useful as it supports excellent bone regeneration capacity and minimizes the possibility of foreign body reaction,genetic diseases and disease transmission. Materials and Methods: Implant placement combined with osteoinductive regeneration,preservation of extraction socket, maxillary sinus augmentation, and ridge augmentation using block type,powder type, and block+powder type autobone graft materialwere performed for 250 patients with alveolar bone defect and who visited the Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University from September 2009 to August 2011. Results: Clinical assessment: Among the 250 patients of auto-tooth bone graft, clinical assessment was performed for 133 cases of implant placement. The average initial stabilization of placed implants was 74 implant stability quotient (ISQ). Radiological assessment: The average loss of crestal bone in the mandible as measured 6 months on the average after the application of prosthesis load was 0.29 mm, ranging from 0 mm to 3.0 mm. Histological assessment: In the histological assessment, formation of new bone, densified lamellated bone, trabecular bones, osteoblast, and planting fixtures were investigated. Conclusion: Based on these results, we concluded that auto-tooth bone graft material should be researched further as a good bone graft material with osteoconduction and osteoinduction capacities to replace autogenous bone, which has many limitations.

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Section: Sung-min Park Et Al: Clinical Application Of Auto-tooth Bonementioning

confidence: 99%

Clinical application of auto-tooth bone graft material

Park

Kim

et al. 2012

J Korean Assoc Oral Maxillofac Surg

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“…이종골은 소나 돼지 등의 다른 종의 동물에서 골을 채취한 후 동결건조, 탈회동결건조, 그리고 방사선 조사압 및 열 멸균 등을 거쳐 골전도 능력을 기대하는 골이식재이다 [8]. 그러나 이러한 동종 골과 이종골은 면역반응이나 교차감염면에서 100% 안전하지 는 않다 [18]. 이러한 (Fig.…”

Section: 서 론unclassified

Effect of Porcine Cancellous Bones on Regeneration in Rats with Calvarial Defect

Yoo¹,

Kim²,

Shim³

et al. 2010

Journal of Life Science

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The purpose of this study was to evaluate the effect of porcine cancellous bone as a scaffold in a rat calvarial defect model. Critical-sized defects were created in 30 male Sprague-Dawley rats. The animals were divided into critical defect (CD, n=10), β-tricalcium phosphate (TCP) graft (BT, n=10) and porcine cancellous bone graft (PCB, n=10) groups. Each defect was filled with β-TCP mixed with fibrin glue or porcine cancellous bone powder mixed with fibrin glue. In the CD group, the defect was left empty. All rats were sacrificed at 8 weeks after bone graft surgery, and bone formation was evaluated by gross observation, plain radiography, micro-computed tomography scanning and histological evaluation. Repair of bone defect was the least in the CD group, and significant new bone formation was observed in the PCB group. Grafting of porcine cancellous bone was more efficient for regenerating new bone than grafting β-TCP.

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“…Commercial bone graft material based on allogenic bone that is produced through certain treatment processes is widely used clinically, but only osteoconduction without new bone formation and osteoinduction can be expected and it is not absorbed into tissue and remains for a long time. This implies that it is unclear whether the grafted material participated in bone remodeling through new bone formation and also the fact that it is hard to completely exclude the possibility of disease spreading with this material is a disadvantage 10) . The recent worries concerning bovine spongiform encephalopathy has increased the repulsion in using allergenic bone.…”

Section: Introductionmentioning

confidence: 99%

Bone Healing Capacity of Demineralized Dentin Matrix Materials in a Mini-pig Cranium Defect

Kim¹,

Kim²,

Um³

et al. 2012

Journal of Korean Dental Science

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Risk Assessment of Bovine Spongiform Encephalopathy Transmission Through Bone Graft Material Derived From Bovine Bone Used for Dental Applications

Cited by 112 publications

References 18 publications

Clinical application of auto-tooth bone graft material

Clinical application of auto-tooth bone graft material

Effect of Porcine Cancellous Bones on Regeneration in Rats with Calvarial Defect

Bone Healing Capacity of Demineralized Dentin Matrix Materials in a Mini-pig Cranium Defect

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