Risk assessment of bisphosphonate-related osteonecrosis of the jaw: significance of measurement of urinary cross-linked C-telopeptide of type I collagen
Abstract:We measured urinary cross-linked C-telopeptide of type Ⅰ collagen(CTX)in 72 patients who were receiving bisphosphonate(BPs)treatment to investigate the risk of BPs-related osteonecrosis of the jaw(ONJ). Thirty-six of the 72 patients had developed ONJ, and the other 36 had not. Urine was collected after an overnight fast, and the CTX level was measured by enzyme-linked immunosorbent assay as creatinine-converted values(Crconverted values). The mean Cr-converted value in the BPs-treated patients tended to be low… Show more
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