Risk Assessment in Chinese Hospitalized Patients Comparing the Padua and Caprini Scoring Algorithms

Abstract

The current venous thromboembolism (VTE) guidelines recommend all patients to be assessed for the risk of VTE using risk assessment models (RAMs). The study was to evaluate the performance of the Caprini and Padua RAMs among Chinese hospitalized patients. We reviewed data from 189 patients with deep venous thrombosis (DVT) and 201 non-DVT patients. Deep venous thrombosis risk factors were obtained from all patients. The sensitivity and specificity of the Caprini and Padua scores for all patients were calculated. The receiver operating curve (ROC) and the area under the ROC curve (AUC) were used to evaluate the performance of each score. We documented that age, acute infection, prothrombin time (PT), D-dimer, erythrocyte sedimentation rate, blood platelets, and anticoagulation were significantly associated with the occurrence of DVT ( P < .05). These results were true for all medical and surgical patients group (G1), as well as the analysis of medical versus surgical patients (G2). Finally, analysis of the scores in patients with and without cancer was also done (G3). The Caprini has a higher sensitivity but a lower specificity than the Padua ( P < .05). Caprini has a better predictive ability for the first 2 groups ( P < .05). We found Caprini and Padua scores have a similar predictive value for patients with cancer ( P > .05), while Caprini has a higher predictive ability for no cancer patients in G3 than Padua ( P < .05). For Chinese hospitalized patients, Caprini has a higher sensitivity but a lower specificity than Padua. Overall, Caprini RAM has a better predictive ability than Padua RAM.

A Prospective Observational Cohort of Clinical Outcomes in Medical Inpatients prescribed Pharmacological Thromboprophylaxis Using Different Clinical Risk Assessment Models(COMPT RAMs)

“…This study also reported an overuse of pharmacologic thromboprophylaxis in this patient population without a significant increase in bleeding risk 39 . Another comparative study in a Chinese inpatient population showed that Padua and Caprini RAMs had a similar predictive value in cancer patients with Caprini having a higher predictive value in non-cancer patients 40 . Therefore, Caprini RAM can be appropriately utilized in medical oncology inpatients in the absence of better validated tools in this setting.…”

Extended Venous Thromboembolism Prophylaxis in Medically Ill Patients: An NATF Anticoagulation Action Initiative

“…Several studies are exploring the utility of the Caprini score in medically ill patients and those with cancer. 45,46 The Kucher model is an 8-factor weighted scoring system that uses computer alerts to identify high-risk populations (scores ≥4 points indicate high risk). In a randomized controlled trial, symptomatic VTE rates declined by 41% in high-risk patients after alerts were sent to providers.…”

Establishment of Bp-ann Based Risk Assessment Model for Lower Extremity Deep Venous Thrombosis in Critically Ill Patients : Mullti-centre, Prospective, Descriptive Correlational Study

“…The average AUC of Caprini was 0.7-0.8, Padua was 0.6-0.7 and Wells was 0.56-0.70 in previous study [24][25][26][27] . And in this study, the above RAM were all lower than 0.75, while the study results demonstrate that the AUC of the BP-ANN RAM was 0.828, which can signi cantly improve the productivity of LEDVT in critically ill patients.…”