2001
DOI: 10.1351/pac200173060993
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Risk assessment for occupational exposure to chemicals. A review of current methodology (IUPAC Technical Report)

Abstract: Republication or reproduction of this report or its storage and/or dissemination by electronic means is permitted without theAbstract: This paper reviews the methodology available for risk assessment of exposure to substances in the workplace. Assessment starts with the identification and classification of hazard, which must be related to the dose-effect and dose-response information available for the hazards identified. Once the potential for exposure has been characterized, it should be quantified and compar… Show more

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Cited by 48 publications
(9 citation statements)
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“…The mechanism of action is complex and often involves several stages and stressors. An example is carcinogenicity where three stages e initiation, promotion and progression e are involved in a delayed impact on human health (Herber et al, 2001). The differences between methods in the definition of the effect factors rely in the choice of the impact and in the choice of the exposure-to-impact relationships (Different values for the DRF or for the HRD/HRC or choice between DRF and HRD/HRC).…”
Section: Main Differences Between Methodsmentioning
confidence: 99%
“…The mechanism of action is complex and often involves several stages and stressors. An example is carcinogenicity where three stages e initiation, promotion and progression e are involved in a delayed impact on human health (Herber et al, 2001). The differences between methods in the definition of the effect factors rely in the choice of the impact and in the choice of the exposure-to-impact relationships (Different values for the DRF or for the HRD/HRC or choice between DRF and HRD/HRC).…”
Section: Main Differences Between Methodsmentioning
confidence: 99%
“…The Acceptable Daily Intake (ADI) for humans is defined as an estimate of the amount of heavy metals that can be ingested daily over a lifetime without any risk to human health (Benford 2000;Herber et al 2001). The ADI is used widely to describe safe levels of intake, other terms that were used are the reference dose (RfD) and tolerable intakes that are presented daily (TDI or tolerable daily intake) or used to estimate weekly intake (TWI or tolerable weekly intake) (Herrman &Younes 1999).…”
Section: Acceptable Daily Intake (Adi)mentioning
confidence: 99%
“…In the context of health, the dominant paradigm has been that of risk assessment. Initially developed in the 1970s, within ten years this had become established in the USA as a major tool for regulation and risk management [ 11 ]. Silbergeld [ 12 ] thus defined it as "a set of decision rules ... for identifying and quantifying the risks of chemicals and other events for adverse effects to human health, usually cancer".…”
Section: Reviewmentioning
confidence: 99%