Risk assessment and monitoring of dinotefuran and its metabolites for Chinese consumption of apples

Yu, Weiwei; Huang, Min; Chen, Jiaojiao; Wu, Sizhuo; Zheng, Kunming; Zeng, Song; Zhang, Kankan; Hu, Deyu

doi:10.1007/s10661-017-6239-1

Cited by 23 publications

(10 citation statements)

References 29 publications

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“…The residues of dinotefuran recorded in pollen, honey or syrup range from 0.03 ng/g to 147 ng/g [ 11 , 64 – 66 ]. On this basis, a field-realistic level of dinotefuran of 0.01 mg/L was selected as the sublethal concentration in this study.…”

Section: Methodsmentioning

confidence: 99%

Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae)

et al. 2021

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Background Dinotefuran (CAS No. 165252–70-0), a neonicotinoid insecticide, has been used to protect various crops against invertebrate pests and has been associated with numerous negative sublethal effects on honey bees. Long noncoding RNAs (lncRNAs) play important roles in mediating various biological and pathological processes, involving transcriptional and gene regulation. The effects of dinotefuran on lncRNA expression and lncRNA function in the honey bee brain are still obscure. Results Through RNA sequencing, a comprehensive analysis of lncRNAs and mRNAs was performed following exposure to 0.01 mg/L dinotefuran for 1, 5, and 10 d. In total, 312 lncRNAs and 1341 mRNAs, 347 lncRNAs and 1458 mRNAs, and 345 lncRNAs and 1155 mRNAs were found to be differentially expressed (DE) on days 1, 5 and 10, respectively. Gene set enrichment analysis (GSEA) indicated that the dinotefuran-treated group showed enrichment in carbohydrate and protein metabolism and immune-inflammatory responses such as glycine, serine and threonine metabolism, pentose and glucuronate interconversion, and Hippo and transforming growth factor-β (TGF-β) signaling pathways. Moreover, the DE lncRNA TCONS_00086519 was shown by fluorescence in situ hybridization (FISH) to be distributed mainly in the cytoplasm, suggesting that it may serve as a competing endogenous RNA and a regulatory factor in the immune response to dinotefuran. Conclusion This study characterized the expression profile of lncRNAs upon exposure to neonicotinoid insecticides in young adult honey bees and provided a framework for further study of the role of lncRNAs in honey bee growth and the immune response.

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Section: Methodsmentioning

confidence: 99%

Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae)

et al. 2021

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“…= FI (kg) × HR (mg/kg) × IF/b.w. (kg) (Yu et al, ) where IESTI is the international estimated short–term intake, FI is the food intake, HR is the highest residue level and IF is the infusion factor. According to the Chinese Dietary Guidelines, the daily intake of rice and its products in the dietary pattern of the Chinese population is generally 0.2399 kg per capita, and the average body weight in China is 63 kg (Li, Liu, Cui, et al, ).…”

Section: Resultsmentioning

confidence: 99%

Residual level of dimethachlon in rice‐paddy field system and cooked rice determined by gas chromatography with electron capture detector

Sun

Zeng

Zhong

et al. 2018

Biomedical Chromatography

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In this study, a modified quick, easy, cheap, effective, rugged and safe method coupled with gas chromatography with electron capture detection was established to determine dimethachlon residues in paddy soil, rice husk, rice straw, brown rice and cooked rice. The limits of quantification of dimethachlon were 0.01 mg/kg for paddy soil, brown rice and cooked rice and 0.02 mg/kg for rice straw and rice husk. The mean recoveries were in the range 78.59-104.7% with relative standard deviation values of <10% for dimethachlon in the five matrices. For field experiments, the final residues of dimethachlon in paddy soil were < 0.05 mg/kg and were < 1.21 mg/kg in rice straw from six sites. The final residues of dimethachlon in the brown rice at 21, 28 and 35 days after spraying from six sites were 0.08-7.58 mg/kg, and 0.16-30.1 mg/kg in rice husk. Our six test sites covered the main rice-producing areas of China. The routine rice cooking process of a Chinese family could apparently increase the removal of dimethachlon in rice compared with brown rice, and the reduction ratios were > 96%.

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“…The linearity was studied using a standard solution and matrix-matched calibration by analyzing standard samples of 0.010, 0.025, 0.050, 0.10, 0.25, 0.50, and 1.0 mg/L. The matrix effect caused by other components in the sample matrix will interfere with the ionization of target compounds when using an ESI ion source and then affect the accuracy of quantitative analysis method [10,11]. The matrix effect (ME%) was calculated as follows [12]:…”

Section: Methods Validationmentioning

confidence: 99%

Dissipation Behavior, Residue, and Risk Assessment of Benziothiazolinone in Apples

Chai

Liu

et al. 2021

IJERPH

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Benziothiazolinone is the first independently developed fungicide in China. It has been used to effectively control fungal diseases in a variety of fruits, vegetables, and crops. In this study, the degradation behavior and final residue of benziothiazolinone in apples is discussed, and the dietary risk to consumers was evaluated. High-performance liquid chromatography–tandem mass spectrometry (LC-MS/MS) was used to determine benziothiazolinone residues in apple samples from eight different regions of China. The average recovery of benziothiazolinone in apples was 85.5–100.2%, and the relative standard deviation (RSD) was 0.8–14.9%. The limits of the method of quantification of benziothiazolinone in apples was 0.01 mg/kg. Under good agricultural practices (GAP) conditions, the final residues of benziothiazolinone in apples were below 0.01 mg/kg, lower than the maximum residual limit (MRL) of China. Although the degradation half-lives of benziothiazolinone were 23.9 d–33.0 d, the risk quotient (RQ) of benziothiazolinone was 15.5% by calculating the national estimated daily intake and comparing it with the acceptable daily intake. These results suggested that under GAP conditions, the intake of benziothiazolinone from apples exhibits an acceptably low health risk on consumers.

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Risk assessment and monitoring of dinotefuran and its metabolites for Chinese consumption of apples

Cited by 23 publications

References 29 publications

Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae)

Identification of long noncoding RNAs reveals the effects of dinotefuran on the brain in Apis mellifera (Hymenopptera: Apidae)

Residual level of dimethachlon in rice‐paddy field system and cooked rice determined by gas chromatography with electron capture detector

Dissipation Behavior, Residue, and Risk Assessment of Benziothiazolinone in Apples

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