Risk and prediction of dementia in patients with atrial fibrillation — A nationwide population-based cohort study

Atrial Fibrillation, Cognitive Decline and Dementia

“…Some studies have found that higher CHADS 2 and CHA 2 DS 2 -VASc scores, stratification schemes commonly used to inform anticoagulant treatment in persons with AF, predict dementia in these patients. 22, 29 This association is not surprising, given that age, possibly the strongest predictor of dementia, is part of the scores. Dementia-specific risk models are likely to provide more accurate predictions.…”

“…21 Further confirmation of this association came from an analysis in a large administrative databases in Taiwan, including >600,000 individuals, showing a 42% increased risk of dementia in those with AF versus those without AF. 22 A recent systematic review and meta-analysis pooling some of these previous studies and others reported a hazard ratio (95% confidence interval) of dementia of 1.42 (1.17–1.72) comparing individuals with AF to those without AF. 23 …”

Links between parameters of long-term latent memory and progression from paroxysmal to permanent atrial fibrillation during a five-year observation period. A preliminary study

“…It is associated with greater risk of both cardiological and non-cardiological complications, including a decrease in health-related quality of life, cardiac failure, stroke, and death [1,2]. This type of arrhythmia is also related to cognitive impairment [3][4][5][6][7][8]. This form of mental disorder may appear in patients both with organic lesions on neuroradiological brain examination (indicative of, for example, ischaemic stroke, silent cerebral ischaemia, silent brain infarct, damage in the blood vessels of the brain, white matter lesions, or loss of cortical, subcortical, or hippocampal volume) and without [6,[9][10][11][12].…”

Silent Cerebral Infarction in East Asian vs. Non-Asian Atrial Fibrillation Patients ― Meta-Analysis ―

“…For example, Liao et al reported a consistently higher rate of cognitive decline and risk of dementia in patients with AF. 11 These associations are partly due to the increased risk of clinical stroke in AF, but other mechanisms are likely to contribute, including the occurrence of SCI and microbleeds. 12 Current evidence is not sufficient to support a trend of increased prevalence of dementia in East Asia over the last few decades, but AF may contribute to dementia risk.…”