Rising Trends of Obesity in Malaysia; Role of Inflammation and Inflammatory Markers in Obesity Related Insulin Resistance: A Nuclear Factor Kappa B (Nfkb) Perspective

Ab, Atif

doi:10.19080/ctbeb.2017.10.555793

Cited by 3 publications

(1 citation statement)

References 20 publications

(30 reference statements)

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“…Significantly, excess adiposity or obesity causes the increased level of circulating fatty acids and inflammation. This can lead to insulin resistance, which in turn can cause type 2 diabetes [1,2]. Facts about overweight and obesity: some recent WHO global estimates follow; in 2016, more than 1.9 billion adults aged ≥18 years were overweight.…”

Section: Introductionmentioning

confidence: 99%

Obesity in Pakistan; Current and Future Perceptions

Amin Baig

2018

CTBEB

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Obesity is currently one of the most common health issues that is increasing day by day, and nearly 30% of world population is overweight or obese. More than 60% of global disease burden will be attributed to chronic disorder associated with obesity by 2020 according to WHO. Obesity is also a cause of many non-communicable diseases (NCD) due to which globally 60-70% deaths occur. Pakistan being the 9th most obese nation in the world suffering from its epidemic, affecting all age group, especially in children and females as compared to men and its ratio will be doubled in coming years due to high carbohydrate intake and physical inactivity and other environmental factors. Nutrigenetics and nutrigenomics which represent a unique approach in nutrition research, combining the application of powerful functional genomics technologies and play an important role in development and treatment of obesity and these preventive measures are required at the population level to control this global health issue.

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Section: Introductionmentioning

confidence: 99%

Obesity in Pakistan; Current and Future Perceptions

Amin Baig

2018

CTBEB

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HIF1 (rs11549465) and NFKB1 (rs28362491) variants association with obesity in Malaysia

2020

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The Mechanistic and Pathophysiological Role of Adiponectin and Resistin towards Regulation of Food Intake and Appetite in Cardiovascular Associated Risk Factor of Metabolic Syndrome

Jumli¹,

Nadeem²

2021

Type 2 Diabetes - From Pathophysiology to Cyber Systems

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Insulin resistance syndrome or syndrome X is also known as metabolic syndrome (MetS). It is an emerging problem globally with the surge of increasing prevalence among urban population of developing countries. The etiology of pathophysiology of metabolic syndrome includes the inflammatory pathways of insulin resistance, deregulated appetite, diet-induced, inflammation-induced obesity, and cardiovascular diseases (CVD). Adipose tissue is an endocrine organ that secrets adipokines like adiponectin and resistin during physiological and pathological states. Moreover, the adipokines associated with diet-induced and inflammation-induced obesity have secondary deteriorating effects on cardiovascular system. Although, the adiponectin and resistin were potentially found in regulating food intake and appetite but their mediating effect on pathophysiology of CVD still needs future investigations. However, the prior studies reported the association of adiponectin and resistin levels with CVD complications related to food intake but still there is need to understand its multifactorial heterogeneity. Therefore, literature suggests figuring out potential target mechanistic and therapeutic approaches of adiponectin and resistin hormone towards food intake and appetite involvement in metabolic syndrome and CVD.

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Rising Trends of Obesity in Malaysia; Role of Inflammation and Inflammatory Markers in Obesity Related Insulin Resistance: A Nuclear Factor Kappa B (Nfkb) Perspective

Cited by 3 publications

References 20 publications

Obesity in Pakistan; Current and Future Perceptions

Obesity in Pakistan; Current and Future Perceptions

HIF1 (rs11549465) and NFKB1 (rs28362491) variants association with obesity in Malaysia

The Mechanistic and Pathophysiological Role of Adiponectin and Resistin towards Regulation of Food Intake and Appetite in Cardiovascular Associated Risk Factor of Metabolic Syndrome

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