Rising time from bed in acute phase after hospitalization predicts frailty at hospital discharge in patients with acute heart failure

Abstract

Frailty in geriatric patients is defined as a syndrome of reduced physiological reserve and vulnerability to stressors broadly classified as acute or chronic illnesses [1]. Frail individuals have markedly elevated risk of adverse health events [2], and frailty is a high-priority issue in cardiovascular medicine [3,4]. Heart failure (HF) is a leading cause of hospitalization [5], and is associated with poor prognosis and quality of life, as well as increased medical costs [6]. Frailty has significant effects on overall health as well as the clinical prognosis of elderly patients with HF [7]. Moreover, frailty at hospital discharge was reported to be associated with increased mortality rate [8]. Therefore, earlier prediction of frailty at discharge is necessary in elderly patients with HF at the time of hospitalization to allow appropriate clinical management, therapeutic decision-making, and for risk stratification. In addition, to predict frailty at discharge, an assessment tool is required that can be used conveniently, rapidly, safely, and immediately after admission. Some previous studies reported that rising from bed, including required time, is associated with decreased activities of daily living (ADLs) [9]. Therefore, we hypothesized that the rising time from bed measured immediately after admission could predict frailty at discharge and/or reduced physical performance with prognostic significance.

Feasibility of home-based cardiac rehabilitation using an integrated telerehabilitation platform in elderly patients with heart failure: A pilot study

“…The mainstay of CR is exercise training, which leads to an increase in exercise tolerance and reduction in symptoms such as dyspnea and fatigue on exertion. Among cardiac diseases, most patients with heart failure (HF) are elderly and affected by frailty and sarcopenia [6][7][8] . CR is considered to be effective in ameliorating these unfavorable conditions and is accordingly strongly recommended in current guidelines [ 3 , 4 ].…”

Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis

“…Of the included studies, 13 studies were considered of having a high risk of bias [ 7 , 31 , 32 , 39 , 41 , 43 , 46 , 52 , 53 , 60 , 61 , 63 , 64 ], 16 as moderate risk of bias [ 18 , 29 , 33 , 36 , 37 , 42 , 44 , 45 , 48 – 50 , 55 , 56 , 58 , 59 , 62 ], and 12 studies had a low risk [ 28 , 30 , 34 , 35 , 38 , 40 , 47 , 51 , 54 , 57 , 65 , 66 ] (Table S2).…”

Nutrition for Elderly Patients with Cardiovascular Diseases

“…Frailty is highly prevalent in specific cardiovascular disease and females [4]. Since interventions such as adequate dietary intake, well-balanced diet, and proper exercise guidance are required, it is important to evaluate frailty in elderly patients with cardiovascular diseases [5]. function.…”